RGD Reference Report - MARCO variants are associated with phagocytosis, pulmonary tuberculosis susceptibility and Beijing lineage. - Rat Genome Database

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MARCO variants are associated with phagocytosis, pulmonary tuberculosis susceptibility and Beijing lineage.

Authors: Thuong, N T T  Tram, T T B  Dinh, T D  Thai, P V K  Heemskerk, D  Bang, N D  Chau, T T H  Russell, D G  Thwaites, G E  Hawn, T R  Caws, M  Dunstan, S J 
Citation: Thuong NT, etal., Genes Immun. 2016 Dec;17(7):419-425. doi: 10.1038/gene.2016.43. Epub 2016 Nov 17.
RGD ID: 41412194
Pubmed: PMID:27853145   (View Abstract at PubMed)
PMCID: PMC5133378   (View Article at PubMed Central)
DOI: DOI:10.1038/gene.2016.43   (Journal Full-text)

Macrophage receptor with collagenous structure (MARCO) has an important role in the phagocytosis of Mycobacterium tuberculosis (M. tuberculosis). We hypothesized that MARCO polymorphisms are associated with phagocytosis, tuberculosis (TB) disease susceptibility and presentation, and infecting lineage. We used a human cellular model to examine how MARCO genotype mediates the immune response; a case-control study to investigate tuberculosis host genetic susceptibility; and a host-pathogen genetic analysis to study host-pathogen interactions. Two MARCO heterozygous (AG) genotypes (single-nucleotide polymorphisms rs2278589 and rs6751745) were associated with impaired phagocytosis of M. tuberculosis trehalose 6,6'-dimycolate-cord factor and β-glucan-coated beads in macrophages. The heterozygous genotypes of rs2278589 and rs6751745 were also associated with increased risk of pulmonary TB (PTB; rs2278589, P=0.001, odds ratio (OR)=1.6; rs6751745, P=0.009, OR=1.4), and with severe chest X-ray abnormalities (P=0.007, OR=1.6). These two genotypes were also associated with the Beijing lineage (rs2278589, P=0.001, OR=1.7; rs6751745, P=0.01, OR=1.5). Together, these results suggest that MARCO polymorphisms may regulate phagocytosis of M. tuberculosis and susceptibility and severity of PTB. They also suggest MARCO genotype and Beijing strains may interact to increase the risk of PTB.




  
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Species
Term
Qualifier
Evidence
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Original Reference(s)
MARCOHumanpulmonary tuberculosis susceptibilityIAGP DNA:SNPs: :rs2278589 more ...RGD 
MarcoMousepulmonary tuberculosis susceptibilityISOMARCO (Homo sapiens)DNA:SNPs: :rs2278589 more ...RGD 
MarcoRatpulmonary tuberculosis susceptibilityISOMARCO (Homo sapiens)DNA:SNPs: :rs2278589 more ...RGD 


Genes (Rattus norvegicus)
Marco  (macrophage receptor with collagenous structure)

Genes (Mus musculus)
Marco  (macrophage receptor with collagenous structure)

Genes (Homo sapiens)
MARCO  (macrophage receptor with collagenous structure)