RGD Reference Report - A nonsense mutation of Stim1 identified in stroke-prone spontaneously hypertensive rats decreased the store-operated calcium entry in astrocytes. - Rat Genome Database

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A nonsense mutation of Stim1 identified in stroke-prone spontaneously hypertensive rats decreased the store-operated calcium entry in astrocytes.

Authors: Ohara, Hiroki  Nabika, Toru 
Citation: Ohara H and Nabika T, Biochem Biophys Res Commun. 2016 Aug 5;476(4):406-411. doi: 10.1016/j.bbrc.2016.05.134. Epub 2016 May 27.
RGD ID: 41404721
Pubmed: (View Article at PubMed) PMID:27237974
DOI: Full-text: DOI:10.1016/j.bbrc.2016.05.134

We previously identified a nonsense mutation in the stromal interaction molecule-1 (Stim1) resulting in expression of a truncated STIM1 in the stroke-prone spontaneously hypertensive rat (SHRSP). In this study, we evaluated activity of the store-operated Ca(2+)-entry (SOCE) regulated by STIM1 to clarify putative functional abnormalities of the truncated STIM1. As a result, reduced SOCE activity resulting in suppression of cyclooxygenase-2 expression induced by SOCE was found in cultured astrocytes with the truncated STIM1 when compared with those with the wild-type. Our results indicated that the truncated STIM1 impaired Ca(2+) signaling regulated by SOCE and that the impaired SOCE activity might be responsible for pathological phenotypes in SHRSP.

Annotation

Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Stim1  (stromal interaction molecule 1)

Objects referenced in this article
Strain SHRSP.WKY-(D1Smu13-D1Wox33)/Izm null Rattus norvegicus
Strain SHRSP.WKY-(D1Smu13)/Izm null Rattus norvegicus

Additional Information