RGD Reference Report - Sperm-associated antigen 9 is a promising marker for early diagnosis of endometrial cancer. - Rat Genome Database

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Sperm-associated antigen 9 is a promising marker for early diagnosis of endometrial cancer.

Authors: Baser, Eralp  Togrul, Cihan  Ozgu, Emre  Ayhan, Sevgi  Caglar, Mete  Erkaya, Salim  Gungor, Tayfun 
Citation: Baser E, etal., Asian Pac J Cancer Prev. 2013;14(12):7635-8. doi: 10.7314/apjcp.2013.14.12.7635.
RGD ID: 30296659
Pubmed: PMID:24460345   (View Abstract at PubMed)
DOI: DOI:10.7314/apjcp.2013.14.12.7635   (Journal Full-text)


BACKGROUND: Sperm-associated antigen 9 (SPAG9) has been recently proposed as a novel biomarker for early diagnosis of several human tumors, including ovarian, cervical and breast cancers. Its clinical value remains to be clarified for endometrial cancer (EC). In this study, we investigated the utility of serum SPAG9 levels in diagnosis of EC and its association with important clinicopathological parameters.
MATERIALS AND METHODS: This cross-sectional study was performed at a tertiary women's referral center in Ankara, Turkey. Preoperative serum samples were collected from patients surgically treated for endometrial cancer between June 2012-April 2013. Similar aged women with a biopsy proven benign endometrium were used as controls. Serum SPAG9 levels were measured with an enzyme-linked immunosorbent assay (ELISA) method and assessed for links with clinicopathological factors. Receiver operating characteristic (ROC) curve analysis was performed to assess power of SPAG9 levels for EC prediction. P values less than 0.05 were considered statistically significant.
RESULTS: A total of 63 women with EC and 27 with benign endometrium were included in the study. Mean age in the EC group was 58.7±1.1. Median SPAG9 levels in the EC and control groups were 18.3 (range, 12.7-53.8) and 14.1 (range, 4.3-65.3), respectively (p<0.001). A cut-off value of 17 ng/ml for SPAG9 predicted presence of malignant endometrium with 74% sensitivity and 83% specificity [Area under curve (AUC)=0.82, p<0.001]. SPAG9 levels did not demonstrate any significant association with histological type, FIGO stage, tumor grade, size, myometrial invasion, lymphovascular space invasion, cervical involvement, adnexal involvement, peritoneal cytology or lymph node status (all p>0.05).
CONCLUSIONS: Testing for SPAG9 may be useful for early detection of EC in asymptomatic high-risk women. Its role in post-treatment follow-up and early detection of recurrence should be assessed in future trials.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SPAG9Humanendometrial cancer  IEP protein:increased expression:serum:RGD 
Spag9Ratendometrial cancer  ISOSPAG9 (Homo sapiens)protein:increased expression:serum:RGD 
Spag9Mouseendometrial cancer  ISOSPAG9 (Homo sapiens)protein:increased expression:serum:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Spag9  (sperm associated antigen 9)

Genes (Mus musculus)
Spag9  (sperm associated antigen 9)

Genes (Homo sapiens)
SPAG9  (sperm associated antigen 9)


Additional Information