RGD Reference Report - Syndecan-2 regulates transforming growth factor-beta signaling. - Rat Genome Database

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Syndecan-2 regulates transforming growth factor-beta signaling.

Authors: Chen, L  Klass, C  Woods, A 
Citation: Chen L, etal., J Biol Chem. 2004 Apr 16;279(16):15715-8. Epub 2004 Feb 19.
RGD ID: 2311706
Pubmed: PMID:14976204   (View Abstract at PubMed)
DOI: DOI:10.1074/jbc.C300430200   (Journal Full-text)

Transforming growth factor-beta (TGF-beta) has multiple functions including increasing extracellular matrix deposition in fibrosis. It functions through a complex family of cell surface receptors that mediate downstream signaling. We report here that a transmembrane heparan sulfate proteoglycan, syndecan-2 (S2), can regulate TGF-beta signaling. S2 protein increased in the renal interstitium in diabetes and regulated TGF-beta-mediated increased matrix deposition in vitro. Transfection of renal papillary fibroblasts with S2 or a S2 construct that has a truncated cytoplasmic domain (S2DeltaS) promoted TGF-beta binding and S2 core protein ectodomain directly bound TGF-beta. Transfection with S2 increased the amounts of type I and type II TGF-beta receptors (TbetaRI and TbetaRII), whereas S2DeltaS was much less effective. In contrast, S2DeltaS dramatically increased the level of type III TGF-beta receptor (TbetaRIII), betaglycan, whereas S2 resulted in a decrease. Syndecan-2 specifically co-immunoprecipitated with betaglycan but not with TbetaRI or TbetaRII. This is a novel mechanism of control of TGF-beta action that may be important in fibrosis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SDC2Humantype 2 diabetes mellitus  IEP protein:increased expression:kidneyRGD 
Sdc2Rattype 2 diabetes mellitus  ISOSDC2 (Homo sapiens)protein:increased expression:kidneyRGD 
Sdc2Mousetype 2 diabetes mellitus  ISOSDC2 (Homo sapiens)protein:increased expression:kidneyRGD 

Objects Annotated

Genes (Rattus norvegicus)
Sdc2  (syndecan 2)

Genes (Mus musculus)
Sdc2  (syndecan 2)

Genes (Homo sapiens)
SDC2  (syndecan 2)


Additional Information