RGD Reference Report - Chronic allergy to dietary ovalbumin induces lymphocyte migration to rat small intestinal mucosa that is inhibited by MAdCAM-1. - Rat Genome Database

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Chronic allergy to dietary ovalbumin induces lymphocyte migration to rat small intestinal mucosa that is inhibited by MAdCAM-1.

Authors: Ogawa, T  Miura, S  Tsuzuki, Y  Ogino, T  Teramoto, K  Inamura, T  Watanabe, C  Hokari, R  Nagata, H  Ishii, H 
Citation: Ogawa T, etal., Am J Physiol Gastrointest Liver Physiol. 2004 May;286(5):G702-10. Epub 2003 Dec 11.
RGD ID: 2311549
Pubmed: PMID:14670821   (View Abstract at PubMed)
DOI: DOI:10.1152/ajpgi.00183.2003   (Journal Full-text)

Few models have described a chronic food allergy with morphological changes in the intestinal mucosa. Here we established an ovalbumin (OVA)-induced, cell-mediated, allergic rat model and examined lymphocyte migration in the gut. Brown Norway rats were intraperitoneally sensitized to OVA and then given 10 mg OVA/day by gastric intubation for 6 wk. Lymphocyte subsets and adhesion molecules were examined immunohistochemically, and the migration of T lymphocytes to microvessels of Peyer's patches and villus mucosa was observed by using an intravital microscope. Serum OVA-specific IgG and IgE levels were increased in animals repeatedly exposed to OVA. Significant villus atrophy and increased crypt depth was accompanied by increased infiltration of T lymphocytes in the small intestinal mucosa of the group given OVA. Expression of rat mast cell protease II and of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) was also increased in these groups. The administration of anti-MAdCAM-1 antibody significantly attenuated the OVA-induced changes in the mucosal architecture and in CD4 T lymphocyte infiltration. Intravital observation demonstrated that in rats with a chronic allergy, T lymphocytes significantly accumulated in villus microvessels as well as in Peyer's patches via a MAdCAM-1-dependent process. Our model of chronic food allergy revealed that lymphocyte migration was increased with MAdCAM-1 upregulation.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
food allergy  ISOMadcam1 (Rattus norvegicus)2311549; 2311549 RGD 
food allergy  IMP 2311549 RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
positive regulation of leukocyte migration  IMP 2311549 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Madcam1  (mucosal vascular addressin cell adhesion molecule 1)

Genes (Mus musculus)
Madcam1  (mucosal vascular addressin cell adhesion molecule 1)

Genes (Homo sapiens)
MADCAM1  (mucosal vascular addressin cell adhesion molecule 1)


Additional Information