RGD Reference Report - Interferon-gamma-increased adherence of lymphocytes to high endothelial venules. - Rat Genome Database

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Interferon-gamma-increased adherence of lymphocytes to high endothelial venules.

Authors: Hendriks, HR  Korn, C  Mebius, RE  Kraal, G 
Citation: Hendriks HR, etal., Immunology. 1989 Oct;68(2):221-6.
RGD ID: 2311500
Pubmed: PMID:2509328   (View Abstract at PubMed)
PMCID: PMC1385421   (View Article at PubMed Central)

Recirculating lymphocytes specifically adhere to and migrate through endothelium lining high endothelial venules (HEV), using specific and non-specific receptor-ligand systems. Interferons (IFN) profoundly affect the traffic of lymphocytes. Therefore the effects of interferon-gamma (IFN-gamma) on lymphocytes with respect to their interaction with HEV endothelium in lymph nodes were studied using the frozen section assay. In addition the organ-specificity of T- and B-lymphocyte adherence to HEV was investigated. Lymphocytes from spleen and peripheral lymph nodes showed increased binding to HEV of up to 35% compared to control lymphocytes after in vivo administration of IFN-gamma. The specificity of their binding did not change in terms of T:B-cell ratios. Increased adherence was also found by preincubation of lymphocytes with IFN-gamma in The enhanced binding was not due to increased expression of Mel-14 homing receptors and LFA-1 molecules on T and B lymphocytes, as shown by fluorescence-activated cell sorter analysis and antibody-blocking studies in the frozen section assay. Apparently IFN-gamma induces an additional Mel-14-independent and LFA-1-independent adhesion mechanism on lymphocytes.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IfngRatpositive regulation of cell adhesion  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ifng  (interferon gamma)


Additional Information