RGD Reference Report - Hippocampal signaling cascades are modulated in voluntary and treadmill exercise rats. - Rat Genome Database

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Hippocampal signaling cascades are modulated in voluntary and treadmill exercise rats.

Authors: Chen, WQ  Viidik, A  Skalicky, M  Hoger, H  Lubec, G 
Citation: Chen WQ, etal., Electrophoresis. 2007 Dec;28(23):4392-400.
RGD ID: 2302822
Pubmed: PMID:17963288   (View Abstract at PubMed)
DOI: DOI:10.1002/elps.200700336   (Journal Full-text)

Systematic protein expression studies in the brain of exercising and sedentary animals have not been carried out for far. Signaling proteins are main structures regulating hippocampal function and we decided to determine differences in signaling protein levels in rat hippocampus by a proteomic approach. Aged, male Sprague-Dawley rats, 23 months old, were used for the study: the first group consisted of sedentary rats, the second of rats with voluntary exercise from 5 to 23 months and the third was performing involuntary exercise on a treadmill from 5 to 23 months. 2-DE with subsequent mass spectrometrical identification of spots followed by quantification of spots was carried out. Annexin A5, A3, phosphatidylethanolamine-binding protein, guanine nucleotide-binding protein G(I)/G(S)/G(T), 14-3-3 protein gamma, 14-3-3 protein zeta/delta, prohibitin, visinin-like 1, protein phosphatase 1, septin 8, phosphoprotein enriched in astrocytes 15, transcription factor Pur-beta, EEA1 protein, SH3 domain-binding glutamic acid-rich-like protein 2, and cell division cycle 42 showed differential protein levels in the three groups. These results form the basis for functional studies elucidating mechanisms and links between exercise and hippocampal signaling and function.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Pebp1Ratresponse to activity  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pebp1  (phosphatidylethanolamine binding protein 1)


Additional Information