RGD Reference Report - Increasing expression of extracellular matrix metalloprotease inducer in ovary tumors: tissue microarray analysis of immunostaining score with clinicopathological parameters.

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Increasing expression of extracellular matrix metalloprotease inducer in ovary tumors: tissue microarray analysis of immunostaining score with clinicopathological parameters.
Authors:	Jin, JS Yao, CW Loh, SH Cheng, MF Hsieh, DS Bai, CY
Citation:	Jin JS, etal., Int J Gynecol Pathol. 2006 Apr;25(2):140-6.
RGD ID:	2289053
Pubmed:	PMID:16633062 (View Abstract at PubMed)
DOI:	DOI:10.1097/01.pgp.0000189244.57145.84 (Journal Full-text)
Ovary cancer invasion is responsible for both local tissue destruction and distant metastasis. Invasion is largely mediated by matrix metalloproteases that are thought to be induced by tumor cell-derived extracellular matrix metalloprotease inducer (EMMPRIN) in surrounding fibroblasts. We hypothesized that EMMPRIN isoverexpressed in ovary tumors. Immunohistochemical analysis of EMMPRIN was performed in tissue microarrays of ovary neoplasms including 84 cases of serous adenocarcinoma, 23 cases of mucinous adenocarcinoma, 10 cases of endometrioid adenocarcinoma, 12 cases of yolk sac tumor, 12 cases of clear cell carcinoma, 8 cases of dysgerminoma, 8 cases of granulosa cell tumor, 6 cases of transitional cell carcinoma, and 6 cases of Brenner tumor. All malignant ovary tumors showed significant immunohistochemical expression of EMMPRIN. The EMMPRIN scores in malignant ovary tumors were significantly higher than their nontumor counterparts (313+/-28 for serous adenocarcinoma; 308+/-25 for mucinous adenocarcinoma; 187+/-19 for endometrioid adenocarcinoma; 265+/-23 for yolk sac tumors; 87+/-13 for clear cellcarcinoma; 126+/-15 for dysgerminoma; 243+/-26 for granulosa cell tumor; 87+/-16 for transitional cell carcinoma). The EMMPRIN score was significantly higher in serous adenocarcinomas than in serous adenomas and serous borderline tumors and was correlated with nodal stage. Our findings show for the first time that EMMPRIN is overexpressed in all malignant ovary tumors.

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
BSG	Human	ovary serous adenocarcinoma		IEP		protein:increased expression:ovary	RGD
Bsg	Rat	ovary serous adenocarcinoma		ISO	BSG (Homo sapiens)	protein:increased expression:ovary	RGD
Bsg	Mouse	ovary serous adenocarcinoma		ISO	BSG (Homo sapiens)	protein:increased expression:ovary	RGD

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Genes (Rattus norvegicus)

Bsg (basigin)

Genes (Mus musculus)

Bsg (basigin)

Genes (Homo sapiens)

BSG (basigin (Ok blood group))

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Increasing expression of extracellular matrix metalloprotease inducer in ovary tumors: tissue microarray analysis of immunostaining score with clinicopathological parameters.