RGD Reference Report - Decreases in the expression of CGRP and galanin mRNA in central and peripheral neurons related to the control of blood pressure following experimental hypertension in rats. - Rat Genome Database

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Decreases in the expression of CGRP and galanin mRNA in central and peripheral neurons related to the control of blood pressure following experimental hypertension in rats.

Authors: Coelho, EF  Ferrari, MF  Maximino, JR  Chadi, G  Fior-Chadi, DR 
Citation: Coelho EF, etal., Brain Res Bull. 2004 Jul 30;64(1):59-66.
RGD ID: 1624333
Pubmed: PMID:15275958   (View Abstract at PubMed)
DOI: DOI:10.1016/j.brainresbull.2004.05.003   (Journal Full-text)

Calcitonin gene-related peptide (alpha CGRP) and galanin (GAL) are peptides known to participate in central mechanisms of blood pressure control. Nonetheless, variations in the synthesis of the peptides in response to a hypertensive challenge are not well described, specially using a model, which allows acute and chronic analyses. In this study, we have employed in situ hybridization to analyse changes in mRNA expression of alpha CGRP and GAL in the nucleus tractus solitarii (NTS), hypothalamic paraventricular nucleus (PVN) as well as petrosal and nodose ganglia after aortic coarctation-induced hypertension in rats. Acute (2h) and chronic (3 and 7 days) analyses were performed in order to evaluate the involvement of both peptides in different periods of hypertension. The analysis of relative mRNA levels showed significant differences between sham-operated and aortic coarcted hypertensive rats. alpha CGRP mRNA expression was decreased 2h (40%) and 3 days (42%) in nodose and petrosal ganglia, respectively, after coarctation. No changes in CGRP mRNA signal were seen in the NTS and PVN in the analysed periods. GAL mRNA expression was decreased in the NTS (19%) and PVN (55%), 3 and 7 days, respectively, after coarctation-induced hypertension. No changes in GAL mRNA expression were observed in petrosal and nodose ganglia following aortic coarctation. Data suggest that alpha CGRP and GAL may participate in the mechanisms involved in the establishment/maintenance of hypertension induced by aortic coarctation. Acute changes might be involved with the adaptation to the hypertensive state, while changes at the chronic phase might be related to counteraction of hypertension.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypertension  ISOGal (Rattus norvegicus)1624333; 1624333mRNA:decreased expression:paraventricular hypothalamic nucleus and solitary tract nucleusRGD 
hypertension  IEP 1624333mRNA:decreased expression:paraventricular hypothalamic nucleus and solitary tract nucleusRGD 

Objects Annotated

Genes (Rattus norvegicus)
Gal  (galanin and GMAP prepropeptide)

Genes (Mus musculus)
Gal  (galanin and GMAP prepropeptide)

Genes (Homo sapiens)
GAL  (galanin and GMAP prepropeptide)


Additional Information