RGD Reference Report - Large expansion of the ATTCT pentanucleotide repeat in spinocerebellar ataxia type 10. - Rat Genome Database

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Large expansion of the ATTCT pentanucleotide repeat in spinocerebellar ataxia type 10.

Authors: Matsuura, T  Yamagata, T  Burgess, DL  Rasmussen, A  Grewal, RP  Watase, K  Khajavi, M  McCall, AE  Davis, CF  Zu, L  Achari, M  Pulst, SM  Alonso, E  Noebels, JL  Nelson, DL  Zoghbi, HY  Ashizawa, T 
Citation: Matsuura T, etal., Nat Genet. 2000 Oct;26(2):191-4.
RGD ID: 1599410
Pubmed: PMID:11017075   (View Abstract at PubMed)
DOI: DOI:10.1038/79911   (Journal Full-text)

Spinocerebellar ataxia type 10 (SCA10; MIM 603516; refs 1,2) is an autosomal dominant disorder characterized by cerebellar ataxia and seizures. The gene SCA10 maps to a 3.8-cM interval on human chromosome 22q13-qter (refs 1,2). Because several other SCA subtypes show trinucleotide repeat expansions, we examined microsatellites in this region. We found an expansion of a pentanucleotide (ATTCT) repeat in intron 9 of SCA10 in all patients in five Mexican SCA10 families. There was an inverse correlation between the expansion size, up to 22.5 kb larger than the normal allele, and the age of onset (r2=0.34, P=0.018). Analysis of 562 chromosomes from unaffected individuals of various ethnic origins (including 242 chromosomes from Mexican persons) showed a range of 10 to 22 ATTCT repeats with no evidence of expansions. Our data indicate that the new SCA10 intronic ATTCT pentanucleotide repeat in SCA10 patients is unstable and represents the largest microsatellite expansion found so far in the human genome.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ATXN10HumanSpinocerebellar Ataxias susceptibilityIAGP DNA:repeat:intron 9RGD 
Atxn10RatSpinocerebellar Ataxias susceptibilityISOATXN10 (Homo sapiens) RGD 
Atxn10MouseSpinocerebellar Ataxias susceptibilityISOATXN10 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Atxn10  (ataxin 10)

Genes (Mus musculus)
Atxn10  (ataxin 10)

Genes (Homo sapiens)
ATXN10  (ataxin 10)


Additional Information