RGD Reference Report - Upregulation of ASAP3 contributes to colorectal carcinogenesis and indicates poor survival outcome. - Rat Genome Database

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Upregulation of ASAP3 contributes to colorectal carcinogenesis and indicates poor survival outcome.

Authors: Tian, Haiying  Qian, Jin  Ai, Luoyan  Li, Yueyuan  Su, Wenyu  Kong, Xian-Ming  Xu, Jie  Fang, Jing-Yuan 
Citation: Tian H, etal., Cancer Sci. 2017 Aug;108(8):1544-1555. doi: 10.1111/cas.13281. Epub 2017 Jun 14.
RGD ID: 153305906
Pubmed: PMID:28502111   (View Abstract at PubMed)
PMCID: PMC5543456   (View Article at PubMed Central)
DOI: DOI:10.1111/cas.13281   (Journal Full-text)

The function and clinical implication of ArfGAP with SH3 domain, ankyrin repeat, and PH domain 3 (ASAP3) in colorectal cancer (CRC) remains undefined. In the present study, we showed that the expression level of ASAP3 was dramatically increased in CRC and its upregulation was associated with American Joint Committee on Cancer stage (P < 0.001) and poor prognosis (P = 0.0022). The combination of stage and ASAP3 expression improved the prediction of survival in CRC patients. Suppression of ASAP3 inhibited cell proliferation by inducing G1 phase arrest without influencing apoptosis. ASAP3 promoted growth of colon tumors in mice with colitis, and accelerated cell invasion and migration in vitro. Increased ASAP3 was associated with activation of the nuclear factor-κB (NF-κB) canonical pathway in CRC. Upregulation of ASAP3 increased the phosphorylation and nuclear translocation of the p65 NF-κB subunit. Mechanistically, ASAP3 interacts with NF-κB essential modulator (NEMO) and could reduce the polyubiquitinylation of NEMO. Overall, ASAP3 might regulate NF-κB via binding to NEMO. ASAP3 acts as an oncogene in colonic cancer and could be a potential biomarker of colon carcinogenesis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ASAP3Humancolorectal cancer disease_progressionIEP mRNA and protein:increased expression:colon (human)RGD 
ASAP3Humancolorectal cancer  ISOAsap3 (Mus musculus) RGD 
Asap3Ratcolorectal cancer disease_progressionISOASAP3 (Homo sapiens)mRNA and protein:increased expression:colon (human)RGD 
Asap3Ratcolorectal cancer  ISOAsap3 (Mus musculus) RGD 
Asap3Mousecolorectal cancer disease_progressionISOASAP3 (Homo sapiens)mRNA and protein:increased expression:colon (human)RGD 
Asap3Mousecolorectal cancer  IMP  RGD 
IkbkgMousecolorectal cancer  IPI1618153 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Asap3  (ArfGAP with SH3 domain, ankyrin repeat and PH domain 3)

Genes (Mus musculus)
Asap3  (ArfGAP with SH3 domain, ankyrin repeat and PH domain 3)
Ikbkg  (inhibitor of kappaB kinase gamma)

Genes (Homo sapiens)
ASAP3  (ArfGAP with SH3 domain, ankyrin repeat and PH domain 3)


Additional Information