RGD Reference Report - New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia. - Rat Genome Database

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New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia.

Authors: Nishida, Nao  Sawai, Hiromi  Kashiwase, Koichi  Minami, Mutsuhiko  Sugiyama, Masaya  Seto, Wai-Kay  Yuen, Man-Fung  Posuwan, Nawarat  Poovorawan, Yong  Ahn, Sang Hoon  Han, Kwang-Hyub  Matsuura, Kentaro  Tanaka, Yasuhito  Kurosaki, Masayuki  Asahina, Yasuhiro  Izumi, Namiki  Kang, Jong-Hon  Hige, Shuhei  Ide, Tatsuya  Yamamoto, Kazuhide  Sakaida, Isao  Murawaki, Yoshikazu  Itoh, Yoshito  Tamori, Akihiro  Orito, Etsuro  Hiasa, Yoichi  Honda, Masao  Kaneko, Shuichi  Mita, Eiji  Suzuki, Kazuyuki  Hino, Keisuke  Tanaka, Eiji  Mochida, Satoshi  Watanabe, Masaaki  Eguchi, Yuichiro  Masaki, Naohiko  Murata, Kazumoto  Korenaga, Masaaki  Mawatari, Yoriko  Ohashi, Jun  Kawashima, Minae  Tokunaga, Katsushi  Mizokami, Masashi 
Citation: Nishida N, etal., PLoS One. 2014 Feb 10;9(2):e86449. doi: 10.1371/journal.pone.0086449. eCollection 2014.
RGD ID: 150429799
Pubmed: PMID:24520320   (View Abstract at PubMed)
PMCID: PMC3919706   (View Article at PubMed Central)
DOI: DOI:10.1371/journal.pone.0086449   (Journal Full-text)

Previous studies have revealed the association between SNPs located on human leukocyte antigen (HLA) class II genes, including HLA-DP and HLA-DQ, and chronic hepatitis B virus (HBV) infection, mainly in Asian populations. HLA-DP alleles or haplotypes associated with chronic HBV infection or disease progression have not been fully identified in Asian populations. We performed trans-ethnic association analyses of HLA-DPA1, HLA-DPB1 alleles and haplotypes with hepatitis B virus infection and disease progression among Asian populations comprising Japanese, Korean, Hong Kong, and Thai subjects. To assess the association between HLA-DP and chronic HBV infection and disease progression, we conducted high-resolution (4-digit) HLA-DPA1 and HLA-DPB1 genotyping in a total of 3,167 samples, including HBV patients, HBV-resolved individuals and healthy controls. Trans-ethnic association analyses among Asian populations identified a new risk allele HLA-DPB1*09 ∶ 01 (P = 1.36 × 10(-6); OR= 1.97; 95% CI, 1.50-2.59) and a new protective allele DPB1*02 ∶ 01 (P = 5.22 × 10(-6); OR = 0.68; 95% CI, 0.58-0.81) to chronic HBV infection, in addition to the previously reported alleles. Moreover, DPB1*02 ∶ 01 was also associated with a decreased risk of disease progression in chronic HBV patients among Asian populations (P = 1.55 × 10(-7); OR = 0.50; 95% CI, 0.39-0.65). Trans-ethnic association analyses identified Asian-specific associations of HLA-DP alleles and haplotypes with HBV infection or disease progression. The present findings will serve as a base for future functional studies of HLA-DP molecules in order to understand the pathogenesis of HBV infection and the development of hepatocellular carcinoma.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HLA-DPB1HumanChronic Hepatitis B susceptibilityIAGP DNA:polymorphisms and haplotypes:multiple (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HLA-DPB1HumanElevated circulating alanine aminotransferase concentration susceptibilityIAGP DNA:polymorphisms and haplotypes:multipleRGD 
HLA-DPB1HumanViral hepatitis susceptibilityIAGP DNA:polymorphisms and haplotypes:multipleRGD 
Objects Annotated

Genes (Homo sapiens)
HLA-DPB1  (major histocompatibility complex, class II, DP beta 1)


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