RGD Reference Report - Polymorphisms of HLA-DP are associated with response to peginterferon in Caucasian patients with chronic hepatitis B. - Rat Genome Database

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Polymorphisms of HLA-DP are associated with response to peginterferon in Caucasian patients with chronic hepatitis B.

Authors: Brouwer, W P  Sonneveld, M J  Tabak, F  Simon, K  Cakaloglu, Y  Akarca, U S  Zeuzem, S  Ferenci, P  Heathcote, J E  de Knegt, R J  Boonstra, A  Hansen, B E  Janssen, H L A 
Citation: Brouwer WP, etal., Aliment Pharmacol Ther. 2014 Oct;40(7):811-8. doi: 10.1111/apt.12910. Epub 2014 Aug 11.
RGD ID: 150429794
Pubmed: PMID:25109699   (View Abstract at PubMed)
DOI: DOI:10.1111/apt.12910   (Journal Full-text)


BACKGROUND: Polymorphisms of the HLA-DP gene are associated with the natural clearance of the hepatitis B virus in Asian patients.
AIM: To investigate the association of HLA-DP polymorphisms with response to peginterferon (PEG-IFN) in Caucasian chronic hepatitis B (CHB) patients.
METHODS: We studied 262 Caucasian chronic hepatitis B patients infected with HBV genotype A or D, treated with PEG-IFN for 1 year in two randomised controlled trials (HBV 99-01 and PARC study). Response was defined as an HBV DNA <2000 IU/mL at 6 months post-treatment. Variations at HLA-DPA1 and HLA-DPB1 were genotyped.
RESULTS: Of the 262 patients, 58% was HBeAg-positive and HBV genotype A and D was observed in 32% and 68%, respectively. At 6 months post-treatment, 57 (22%) patients had achieved an HBV DNA <2000 IU/mL. HLA-DPB1 was independently associated with virological response [adjusted odds ratio (OR) 1.8, 95% confidence interval (CI):1.1-3.0, P = 0.025], and with an undetectable HBV DNA (adjusted OR 2.4 95% CI: 1.2-4.7, P = 0.015) when adjusted for HBeAg status and other known response modifiers. In HBeAg-positive patients, combined HBeAg seroconversion with HBV DNA <2000 IU/mL was increasingly observed with each addition of an HLA-DPB1 G-allele (adjusted OR 2.7, 95% CI: 1.2-5.9, P = 0.012). Furthermore, HLA-DPA1 and HLA-DPB1 haplotype block GG showed comparable results for virological and combined response.
CONCLUSION: In this large cohort of Caucasian chronic hepatitis B patients infected with HBV genotypes A or D, polymorphisms of HLA-DP are independently associated with both virological and serological response to PEG-IFN therapy at 6 months post-treatment.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HLA-DPB1HumanChronic Hepatitis B treatmentIAGP DNA:polymorphism: :(human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HLA-DPB1HumanElevated circulating alanine aminotransferase concentration treatmentIAGP DNA:polymorphism: :RGD 
HLA-DPB1HumanIncreased hepatitis B virus antibody level treatmentIAGP DNA:polymorphism: :RGD 
HLA-DPB1HumanViral hepatitis treatmentIAGP DNA:polymorphism: :RGD 
Objects Annotated

Genes (Homo sapiens)
HLA-DPB1  (major histocompatibility complex, class II, DP beta 1)


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