RGD Reference Report - Resveratrol protects against experimental induced Reye's syndrome by prohibition of oxidative stress and restoration of complex I activity. - Rat Genome Database

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Resveratrol protects against experimental induced Reye's syndrome by prohibition of oxidative stress and restoration of complex I activity.

Authors: Abdin, Amany  Sarhan, Naglaa 
Citation: Abdin A and Sarhan N, Can J Physiol Pharmacol. 2014 Sep;92(9):780-8. doi: 10.1139/cjpp-2014-0251. Epub 2014 Aug 2.
RGD ID: 14694843
Pubmed: PMID:25162205   (View Abstract at PubMed)
DOI: DOI:10.1139/cjpp-2014-0251   (Journal Full-text)

This study was designed to investigate whether resveratrol could provide protection against Reye's syndrome induced by 4-pentenoic acid in Wistar albino rats. Compared with rats with untreated Reye's syndrome, 1 h pretreatment by low dose resveratrol (10 mg/kg by oral gavage) resulted in marked amelioration in liver functions in the form of significant decrease in serum transaminases (AST, ALT) and plasma ammonia levels, shortening of prothrombin time, and increase in serum albumin levels. In addition, resveratrol prohibited oxidative stress markers, as indicated by a significant increase in GSH and decrease in MDA, with restoration of complex I activity in liver tissues. The classical histopathological presentation in Reye's syndrome of microvesicular steatosis by light microscope and mitochondria distortion by electron microscope has been improved by resveratrol pretreatment. The efficient protection by resveratrol was determined by normalization in serum levels of AST and albumin, as well as complex I activity, GSH, and MDA. In conclusion, pretreatment by resveratrol in low doses could protect against Reye's syndrome partially via prohibition of oxidative stress and restoration of complex I activity. This may provide the opportunity to reconsider aspirin therapy for infants and young children. However, the verification of such results in clinical practice remains a challenge.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
ALBHumanReye syndrome treatmentISOAlb (Rattus norvegicus) RGD 
AlbRatReye syndrome treatmentIEP  RGD 
AlbMouseReye syndrome treatmentISOAlb (Rattus norvegicus) RGD 


Genes (Rattus norvegicus)
Alb  (albumin)

Genes (Mus musculus)
Alb  (albumin)

Genes (Homo sapiens)
ALB  (albumin)