RGD Reference Report - Nigrostriatal proteomics of cypermethrin-induced dopaminergic neurodegeneration: microglial activation-dependent and -independent regulations. - Rat Genome Database

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Nigrostriatal proteomics of cypermethrin-induced dopaminergic neurodegeneration: microglial activation-dependent and -independent regulations.

Authors: Singh, Anand Kumar  Tiwari, Manindra Nath  Dixit, Anubhuti  Upadhyay, Ghanshyam  Patel, Devendra Kumar  Singh, Dhirendra  Prakash, Om  Singh, Mahendra Pratap 
Citation: Singh AK, etal., Toxicol Sci. 2011 Aug;122(2):526-38. doi: 10.1093/toxsci/kfr115. Epub 2011 May 10.
RGD ID: 13208520
Pubmed: PMID:21561882   (View Abstract at PubMed)
DOI: DOI:10.1093/toxsci/kfr115   (Journal Full-text)

The study aimed to identify the differentially expressed nigrostriatal proteins in cypermethrin-induced neurodegeneration and to investigate the role of microglial activation therein. Proteomic approaches were used to identify the differentially expressed proteins. Microglial activation, tyrosine hydroxylase immunoreactivity (TH-IR), dopamine content, and neurobehavioral changes were measured according to the standard procedures. The expressions of α-internexin intermediate filament (α-IIF), ATP synthase D chain (ATP-SD), heat shock protein (Hsp)-70, truncated connexin-47, Hsp-60, mitogen-activated protein kinase-activated kinase-5, nicotinamide adenine dinucleotide dehydrogenase 24k chain precursor, platelet-activating factor acetyl hydrolase 1b-α2 (PAF-AH 1b-α2), and synaptosomal-associated protein-25 (SNAP-25) were altered in the substantia nigra and nicotinamide adenine dinucleotide- specific isocitrate dehydrogenase, phosphatidylethanolamine-binding protein-1, prohibitin, protein disulfide isomerase-endoplasmic reticulum 60 protease, stathmin, and ubiquitin-conjugating enzyme in the striatum along with motor impairment, decreased dopamine and TH-IR, and increased microglial activation after cypermethrin exposure. Minocycline restored α-IIF, ATP-SD chain, truncated connexin-47, Hsp-60, PAF-AH 1b-α2, stathmin and SNAP-25 expressions, motor impairment, dopamine, TH-IR, and microglial activation. The results suggest that cypermethrin produces microglial activation-dependent and -independent changes in the expression patterns of the nigrostriatal proteins leading to dopaminergic neurodegeneration.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GJC2HumanParkinson's disease treatmentISOGjc2 (Rattus norvegicus) RGD 
Gjc2RatParkinson's disease treatmentIEP  RGD 
Gjc2MouseParkinson's disease treatmentISOGjc2 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gjc2  (gap junction protein, gamma 2)

Genes (Mus musculus)
Gjc2  (gap junction protein, gamma 2)

Genes (Homo sapiens)
GJC2  (gap junction protein gamma 2)


Additional Information