RGD Reference Report - Pax6-dependent boundary defines alignment of migrating olfactory cortex neurons via the repulsive activity of ephrin A5. - Rat Genome Database

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Pax6-dependent boundary defines alignment of migrating olfactory cortex neurons via the repulsive activity of ephrin A5.

Authors: Nomura, Tadashi  Holmberg, Johan  Frisen, Jonas  Osumi, Noriko 
Citation: Nomura T, etal., Development. 2006 Apr;133(7):1335-45. Epub 2006 Mar 1.
RGD ID: 12791011
Pubmed: PMID:16510508   (View Abstract at PubMed)
DOI: DOI:10.1242/dev.02290   (Journal Full-text)

Neuronal migration is a prerequisite event for the establishment of highly ordered neuronal circuits in the developing brain. Here, we report Pax6-dependent alignment of the olfactory cortex neurons in the developing telencephalon. These neurons were generated in the dorsal part of telencephalon, migrated ventrally and stopped at the pallium-subpallium boundary (PSB). In Pax6 mutant rat embryos, however, these neurons invaded the ventral part of the telencephalon by crossing the PSB. Ephrin A5, one of the ligands for EphA receptors, was specifically expressed in the ventral part of the telencephalon, and its expression level was markedly reduced in the Pax6 mutant. Gain- and loss-of-function studies of ephrin A5 indicated that ephrin A5 plays an important role in the alignment of olfactory cortex neurons at the PSB. Our results suggest that Pax6-regulated ephrin A5 acts as a repulsive molecule for olfactory cortex neurons in the developing telencephalon.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Pax6Ratsensory neuron migration  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pax6  (paired box 6)


Additional Information