RGD Reference Report - RIP1 kinase activity is critical for skin inflammation but not for viral propagation. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

RIP1 kinase activity is critical for skin inflammation but not for viral propagation.

Authors: Webster, Joshua D  Kwon, Youngsu C  Park, Summer  Zhang, Hua  Corr, Nick  Ljumanovic, Nina  Adedeji, Adeyemi O  Varfolomeev, Eugene  Goncharov, Tatiana  Preston, Jessica  Santagostino, Sara F  Patel, Snahel  Xu, Min  Maher, Jonathan  McKenzie, Brent S  Vucic, Domagoj 
Citation: Webster JD, etal., J Leukoc Biol. 2020 Jun;107(6):941-952. doi: 10.1002/JLB.3MA1219-398R. Epub 2020 Jan 27.
RGD ID: 127229917
Pubmed: PMID:31985117   (View Abstract at PubMed)
PMCID: PMC7317411   (View Article at PubMed Central)
DOI: DOI:10.1002/JLB.3MA1219-398R   (Journal Full-text)

Receptor interacting protein kinase 1 (RIP1) is a critical effector of inflammatory responses and cell death activation. Cell death pathways regulated by RIP1 include caspase-dependent apoptosis and caspase-independent necroptosis. The kinase activity of RIP1 has been associated with a number of inflammatory, neurodegenerative, and oncogenic diseases. In this study, we use the RIP1 kinase inhibitor GNE684 to demonstrate that RIP1 inhibition can effectively block skin inflammation and immune cell infiltrates in livers of Sharpin mutant (Cpdm; chronic proliferative dermatitis) mice in an interventional setting, after disease onset. On the other hand, genetic inactivation of RIP1 (RIP1 KD) or ablation of RIP3 (RIP3 KO) or MLKL (MLKL KO) did not affect testicular pathology of aging male mice. Likewise, infection with vaccinia virus or with mouse gammaherpesvirus MHV68 resulted in similar viral clearance in wild-type, RIP1 KD, and RIP3 KO mice. In summary, this study highlights the benefits of inhibiting RIP1 in skin inflammation, as opposed to its lack of relevance for testicular longevity and the response to certain viral infections.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
RIPK3HumanHerpesviridae Infections  ISORipk3 (Mus musculus) RGD 
Ripk3RatHerpesviridae Infections  ISORipk3 (Mus musculus) RGD 
Ripk3MouseHerpesviridae Infections  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ripk3  (receptor-interacting serine-threonine kinase 3)

Genes (Mus musculus)
Ripk3  (receptor-interacting serine-threonine kinase 3)

Genes (Homo sapiens)
RIPK3  (receptor interacting serine/threonine kinase 3)


Additional Information