RGD Reference Report - Chronic lithium chloride administration to rats decreases brain protein level of epsilon (epsilon) subunit of eukaryotic initiation factor-2B. - Rat Genome Database

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Chronic lithium chloride administration to rats decreases brain protein level of epsilon (epsilon) subunit of eukaryotic initiation factor-2B.

Authors: Bosetti, F  Seemann, R  Rapoport, SI 
Citation: Bosetti F, etal., Neurosci Lett. 2002 Jul 12;327(1):71-3.
RGD ID: 11041884
Pubmed: PMID:12098503   (View Abstract at PubMed)

The eukaryotic initiation factor-2B (eIF-2B) can regulate translation and protein synthesis. We used Western blot analysis to quantify the protein level of the catalytic epsilon (epsilon) subunit of eIF-2B in brains of rats fed lithium chloride (LiCl) for 6 weeks so as to produce a brain lithium concentration that is therapeutically effective in bipolar disorder. The ratio of eIF-2B (epsilon) to actin protein was significantly reduced (P<0.01) in LiCl-fed rats, 0.86+/-0.06 (SE) compared to 1.2+/-0.07 in control rats. These results suggest that a therapeutic level of lithium may downregulate the synthesis of proteins whose translation depends on eIF-2B.



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Gene Eif2b5 eukaryotic translation initiation factor 2B subunit epsilon Rattus norvegicus

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