RGD Reference Report - Distension of the uterus induces HspB1 expression in rat uterine smooth muscle. - Rat Genome Database

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Distension of the uterus induces HspB1 expression in rat uterine smooth muscle.

Authors: White, BG  MacPhee, DJ 
Citation: White BG and MacPhee DJ, Am J Physiol Regul Integr Comp Physiol. 2011 Nov;301(5):R1418-26. doi: 10.1152/ajpregu.00272.2011. Epub 2011 Sep 7.
RGD ID: 10402748
Pubmed: PMID:21900647   (View Abstract at PubMed)
DOI: DOI:10.1152/ajpregu.00272.2011   (Journal Full-text)

The uterine musculature, or myometrium, demonstrates tremendous plasticity during pregnancy under the influences of the endocrine environment and mechanical stresses. Expression of the small stress protein heat shock protein B1 (HspB1) has been reported to increase dramatically during late pregnancy, a period marked by myometrial hypertrophy caused by fetal growth-induced uterine distension. Thus, using unilaterally pregnant rat models and ovariectomized nonpregnant rats with uteri containing laminaria tents to induce uterine distension, we examined the effect of uterine distension on myometrial HspB1 expression. In unilaterally pregnant rats, HspB1 mRNA and Ser(15)-phosphorylated HspB1 (pSer(15) HspB1) protein expression were significantly elevated in distended gravid uterine horns at days 19 and 23 (labor) of gestation compared with nongravid horns. Similarly, pSer(15) HspB1 protein in situ was only readily detectable in the distended horns compared with the nongravid horns at days 19 and 23; however, pSer(15) HspB1 was primarily detectable in situ at day 19 in membrane-associated regions, while it had primarily a cytoplasmic localization in myometrial cells at day 23. HspB1 mRNA and pSer(15) HspB1 protein expression were also markedly increased in ovariectomized nonpregnant rat myometrium distended for 24 h with laminaria tents compared with empty horns. Therefore, uterine distension plays a major role in the stimulation of myometrial HspB1 expression, and increased expression of this small stress protein could be a mechanoadaptive response to the increasing uterine distension that occurs during pregnancy.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Hspb1Ratfemale pregnancy  IEP  RGD 
Hspb1Ratresponse to muscle stretch  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hspb1  (heat shock protein family B (small) member 1)


Additional Information