RGD Reference Report - Gene expression changes in the medial prefrontal cortex and nucleus accumbens following abstinence from cocaine self-administration. - Rat Genome Database

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Gene expression changes in the medial prefrontal cortex and nucleus accumbens following abstinence from cocaine self-administration.

Authors: Freeman, WM  Lull, ME  Patel, KM  Brucklacher, RM  Morgan, D  Roberts, DC  Vrana, KE 
Citation: Freeman WM, etal., BMC Neurosci. 2010 Feb 26;11:29. doi: 10.1186/1471-2202-11-29.
RGD ID: 10045569
Pubmed: PMID:20187946   (View Abstract at PubMed)
PMCID: PMC2837051   (View Article at PubMed Central)
DOI: DOI:10.1186/1471-2202-11-29   (Journal Full-text)

BACKGROUND: Many studies of cocaine-responsive gene expression have focused on changes occurring during cocaine exposure, but few studies have examined the persistence of these changes with cocaine abstinence. Persistent changes in gene expression, as well as alterations induced during abstinence may underlie long-lasting drug craving and relapse liability. RESULTS: Whole-genome expression analysis was conducted on a rat cocaine binge-abstinence model that has previously been demonstrated to engender increased drug seeking and taking with abstinence. Gene expression changes in two mesolimbic terminal fields (mPFC and NAc) were identified in a comparison of cocaine-naive rats with rats after 10 days of cocaine self-administration followed by 1, 10, or 100 days of enforced abstinence (n = 6-11 per group). A total of 1,461 genes in the mPFC and 414 genes in the NAc were altered between at least two time points (ANOVA, p < 0.05; +/- 1.4 fold-change). These genes can be subdivided into: 1) changes with cocaine self-administration that do not persist into periods of abstinence, 2) changes with cocaine self-administration that persist with abstinence, 3) and those not changed with cocaine self-administration, but changed during enforced abstinence. qPCR analysis was conducted to confirm gene expression changes observed in the microarray analysis. CONCLUSIONS: Together, these changes help to illuminate processes and networks involved in abstinence-induced behaviors, including synaptic plasticity, MAPK signaling, and TNF signaling.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Eftud2Ratresponse to cocaine  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Eftud2  (elongation factor Tu GTP binding domain containing 2)


Additional Information