GWAS720232_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS720232_H (mean arterial pressure, alcohol drinking QTL GWAS720232 (human)) Homo sapiens

Symbol: GWAS720232_H
Name: mean arterial pressure, alcohol drinking QTL GWAS720232 (human)
RGD ID: 407071256
Trait: mean arterial pressure, alcohol drinking
Measurement Type: mean arterial blood pressure   (CMO:0000009)    
LOD Score: Not Available
P Value: 3.0E-10
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3811100,739,815 - 100,739,816RGD_MAPPER_PIPELINEGRCh38
GRCh3711100,610,546 - 100,610,547RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS720232_HHumanmean arterial blood pressure  IAGPrs604723405850206Based on the EFO term IDGWAS_CATALOGPMID:29912962

Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS720232_HHumanalcohol drinking  IAGPrs604723405850206 GWAS_CATALOGPMID:29912962
GWAS720232_HHumanmean arterial pressure  IAGPrs604723405850206 GWAS_CATALOGPMID:29912962
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
3500508ARHGAP42Rho GTPase activating protein 4211100687288100993941Human

Position Markers

Peak: (rs604723)
Human AssemblyChrPosition (strand)Source
GRCh3811100,739,815 - 100,739,816RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407389641GWAS1038617_Hsystolic blood pressure QTL GWAS1038617 (human)1e-39systolic blood pressuresystolic blood pressure (CMO:0000004)11100739815100739816Human
407395466GWAS1044442_Hpulse pressure measurement QTL GWAS1044442 (human)3e-33pulse pressure measurementpulse pressure (CMO:0000292)11100739815100739816Human
406999105GWAS648081_Hsystolic blood pressure QTL GWAS648081 (human)6e-81systolic blood pressuresystolic blood pressure (CMO:0000004)11100739815100739816Human
407058950GWAS707926_Hdiastolic blood pressure, alcohol consumption measurement QTL GWAS707926 (human)4e-11diastolic blood pressure, alcohol consumption measurementethanol drink intake rate (CMO:0001407)11100739815100739816Human
407389645GWAS1038621_Hdiastolic blood pressure QTL GWAS1038621 (human)2e-45diastolic blood pressurediastolic blood pressure (CMO:0000005)11100739815100739816Human
407361089GWAS1010065_Hsystolic blood pressure QTL GWAS1010065 (human)2e-86systolic blood pressuresystolic blood pressure (CMO:0000004)11100739815100739816Human
406948487GWAS597463_Hhypertension QTL GWAS597463 (human)8e-10hypertension11100739815100739816Human
407380482GWAS1029458_HAntihypertensive use measurement QTL GWAS1029458 (human)6e-34Antihypertensive use measurement11100739815100739816Human
406979145GWAS628121_Hdiastolic blood pressure QTL GWAS628121 (human)9e-12diastolic blood pressurediastolic blood pressure (CMO:0000005)11100739815100739816Human
407385350GWAS1034326_Happendicular lean mass QTL GWAS1034326 (human)8e-15appendicular lean mass11100739815100739816Human
407072979GWAS721955_Hdiastolic blood pressure, alcohol drinking QTL GWAS721955 (human)3e-31diastolic blood pressure, alcohol drinkingdiastolic blood pressure (CMO:0000005)11100739815100739816Human
407070352GWAS719328_Hdiastolic blood pressure, alcohol drinking QTL GWAS719328 (human)3e-28diastolic blood pressure, alcohol drinkingdiastolic blood pressure (CMO:0000005)11100739815100739816Human
406955666GWAS604642_Hmean arterial pressure QTL GWAS604642 (human)2e-13mean arterial pressuremean arterial blood pressure (CMO:0000009)11100739815100739816Human
407124689GWAS773665_Hmean arterial pressure QTL GWAS773665 (human)2e-12coronary artery diseasemean arterial blood pressure (CMO:0000009)11100739815100739816Human
407251857GWAS900833_Hdiastolic blood pressure QTL GWAS900833 (human)5e-28diastolic blood pressurediastolic blood pressure (CMO:0000005)11100739815100739816Human
407031835GWAS680811_Hcoronary artery disease QTL GWAS680811 (human)3e-09coronary artery disease11100739815100739816Human
407397906GWAS1046882_HAgents acting on the renin-angiotensin system use measurement QTL GWAS1046882 (human)4e-35Agents acting on the renin-angiotensin system use measurement11100739815100739816Human
407071256GWAS720232_Hmean arterial pressure, alcohol drinking QTL GWAS720232 (human)3e-10mean arterial pressure, alcohol drinkingmean arterial blood pressure (CMO:0000009)11100739815100739816Human
1559115SCL20_HSerum cholesterol level QTL 20 (human)3.220.001213Lipid levelLDL cholesterol11100442501126442501Human
407144474GWAS793450_Hcoronary artery disease QTL GWAS793450 (human)8e-14coronary artery disease11100739815100739816Human
407316645GWAS965621_HAgents acting on the renin-angiotensin system use measurement QTL GWAS965621 (human)2e-36Agents acting on the renin-angiotensin system use measurement11100739815100739816Human
407310381GWAS959357_HBeta blocking agent use measurement QTL GWAS959357 (human)1e-10Beta blocking agent use measurement11100739815100739816Human
407419235GWAS1068211_Hdiastolic blood pressure QTL GWAS1068211 (human)4e-85diastolic blood pressurediastolic blood pressure (CMO:0000005)11100739815100739816Human
407355176GWAS1004152_Hdiastolic blood pressure QTL GWAS1004152 (human)3e-42diastolic blood pressurediastolic blood pressure (CMO:0000005)11100739815100739816Human
407119797GWAS768773_Hcardiovascular disease QTL GWAS768773 (human)8e-40cardiovascular disease11100739815100739816Human
407414585GWAS1063561_Hbody height QTL GWAS1063561 (human)4e-14body height (VT:0001253)body height (CMO:0000106)11100739815100739816Human
407250933GWAS899909_Hsystolic blood pressure QTL GWAS899909 (human)2e-30systolic blood pressuresystolic blood pressure (CMO:0000004)11100739815100739816Human
406979385GWAS628361_Hsystolic blood pressure QTL GWAS628361 (human)7e-12systolic blood pressuresystolic blood pressure (CMO:0000004)11100739815100739816Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS597463_H GCST007707 Hypertension 22,566 Japanese ancestry cases, 28,226 Japanese ancestry controls T 0.5467 8E-10 9.097 rs604723 0.0795 hypertension (EFO:0000537)
 PMID:30487518
GWAS604642_H GCST007706 Mean arterial pressure 130,777 Japanese ancestry individuals T 0.5467 2E-13 12.699 rs604723 0.3889 mean arterial pressure (EFO:0006340)
 PMID:30487518
GWAS628121_H GCST007704 Diastolic blood pressure 130,777 Japanese ancestry individuals T 0.5467 9E-12 11.046 rs604723 0.3275 diastolic blood pressure (EFO:0006336)
 PMID:30487518
GWAS628361_H GCST007703 Systolic blood pressure 130,777 Japanese ancestry individuals T 0.55 7E-12 11.155 rs604723 0.5163 systolic blood pressure (EFO:0006335)
 PMID:30487518
GWAS648081_H GCST007087 Systolic blood pressure approximately 422,000 European ancestry individuals ? NR 6E-81 80.222 rs604723 N/A systolic blood pressure (EFO:0006335)
 PMID:30595370
GWAS680811_H GCST005194 Coronary artery disease 34,541 cases, 261,984 controls T 0.295 3E-9 8.523 rs604723 0.04 coronary artery disease (EFO:0001645)
 PMID:29212778
GWAS707926_H GCST006169 Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) 12,758 European ancestry heavy drinkers, 1,326 African American or Afro-Caribbean heavy drinkers, 648 Asian ancestry heavy drinkers, 364 Hispanic or Latin American heavy drinkers, 43,947 European ancestry light drinkers, 8,239 African American or Afro-Caribbean light drinkers, 1,141 Asian ancestry light drinkers, 4,448 Hispanic or Latin American light drinkers T 0.28 4E-11 10.398 rs604723 N/A diastolic blood pressure (EFO:0006336)
alcohol consumption measurement (EFO:0007878)
 PMID:29912962
GWAS719328_H GCST006166 Diastolic blood pressure x alcohol consumption interaction (2df test) 63,607 European ancestry drinkers, 10,193 African American or Afro-Caribbean drinkers, 2,441 Asian ancestry drinkers, 5,084 Hispanic or Latin American drinkers, 27,492 European ancestry non-drinkers, 11,223 African American or Afro-Caribbean non-drinkers, 9,924 Asian ancestry non-drinkers, 3,387 Hispanic or Latin American non-drinkers T 0.28 3E-28 27.523 rs604723 N/A diastolic blood pressure (EFO:0006336)
alcohol drinking (EFO:0004329)
 PMID:29912962
GWAS720232_H GCST006167 Mean arterial pressure x alcohol consumption interaction (2df test) 91,110 European ancestry drinkers and non-drinkers, 21,416 African American or Afro-Caribbean drinkers and non-drinkers, 12,365 Asian ancestry drinkers and non-drinkers, 8,470 Hispanic or Latin American drinkers and non-drinkers T 0.28 3E-10 9.523 rs604723 N/A mean arterial pressure (EFO:0006340)
alcohol drinking (EFO:0004329)
 PMID:29912962
GWAS721955_H GCST006166 Diastolic blood pressure x alcohol consumption interaction (2df test) 63,607 European ancestry drinkers, 10,193 African American or Afro-Caribbean drinkers, 2,441 Asian ancestry drinkers, 5,084 Hispanic or Latin American drinkers, 27,492 European ancestry non-drinkers, 11,223 African American or Afro-Caribbean non-drinkers, 9,924 Asian ancestry non-drinkers, 3,387 Hispanic or Latin American non-drinkers T 0.28 3E-31 30.523 rs604723 N/A diastolic blood pressure (EFO:0006336)
alcohol drinking (EFO:0004329)
 PMID:29912962
None Available GCST90309346 Hypertension (confirmatory factor analysis Factor 12) 338,391 European ancestry individuals ? NR 1E-31 31 rs604723 N/A hypertension (EFO:0000537)
 PMID:38965376
GWAS768773_H GCST007072 Cardiovascular disease approximately 459,000 European ancestry individuals ? NR 8E-40 39.097 rs604723 N/A cardiovascular disease (EFO:0000319)
 PMID:30595370
GWAS773665_H GCST003275 Mean arterial pressure 31,516 East Asian ancestry individuals, 35,352 European ancestry individuals, 33,126 South Asian ancestry individuals T 0.4109 2E-12 11.699 rs604723 0.4417 mean arterial pressure (EFO:0006340)
 PMID:26390057
GWAS793450_H GCST010866 Coronary artery disease 25,892 Japanese ancestry cases, 95,342 European ancestry cases, 142,336 Japanese ancestry controls, 385,488 European ancestry controls ? NR 8E-14 13.097 rs604723 0.0392671 coronary artery disease (EFO:0001645)
 PMID:33020668
GWAS899909_H GCST90301696 Systolic blood pressure 174,664 British ancestry females T NR 2E-30 29.699 rs604723 0.04 systolic blood pressure (EFO:0006335)
 PMID:38459180
GWAS900833_H GCST90301699 Diastolic blood pressure 174,664 British ancestry females T NR 5E-28 27.302 rs604723 0.04 diastolic blood pressure (EFO:0006336)
 PMID:38459180
GWAS959357_H GCST007927 Medication use (beta blocking agents) 31,700 European ancestry cases, 192,324 European ancestry controls T 0.273879 1E-10 10 rs604723 0.06016691 Beta blocking agent use measurement (EFO:0009929)
 PMID:31015401
GWAS965621_H GCST007930 Medication use (agents acting on the renin-angiotensin system) 62,752 European ancestry cases, 174,778 European ancestry controls T 0.271336 2E-36 35.699 rs604723 0.08634143 Agents acting on the renin-angiotensin system use measurement (EFO:0009931)
 PMID:31015401
GWAS1004152_H GCST90018952 Diastolic blood pressure 340,162 European ancestry individuals, 145,515 East Asian ancestry individuals C NR 3E-42 41.523 rs604723 0.0289 diastolic blood pressure (EFO:0006336)
 PMID:34594039
GWAS1010065_H GCST90310294 Systolic blood pressure 1,028,980 European ancestry individuals C NR 2E-86 85.699 rs604723 0.5377 systolic blood pressure (EFO:0006335)
 PMID:38689001
GWAS1029458_H GCST90250905 Medication use for hypertension (number of purchases) 567,671 European ancestry individuals ? NR 6E-34 33.222 rs604723 0.019209 Antihypertensive use measurement (EFO:0009927)
 PMID:36653479
GWAS1034326_H GCST90000025 Appendicular lean mass 450,243 European ancestry individuals T 0.2752 8E-15 14.097 rs604723 0.0166 appendicular lean mass (EFO:0004980)
 PMID:33097823
GWAS1038617_H GCST90301695 Systolic blood pressure 349,328 British ancestry individuals T NR 1E-39 39 rs604723 0.03 systolic blood pressure (EFO:0006335)
 PMID:38459180
GWAS1038621_H GCST90301698 Diastolic blood pressure 349,328 British ancestry individuals T NR 2E-45 44.699 rs604723 0.04 diastolic blood pressure (EFO:0006336)
 PMID:38459180
GWAS1044442_H GCST90310296 Pulse pressure 1,028,980 European ancestry individuals C NR 3E-33 32.523 rs604723 0.2334 pulse pressure measurement (EFO:0005763)
 PMID:38689001
None Available GCST90132314 Coronary artery disease 181,522 European ancestry, unknown cases, 984,168 European ancestry, unknown controls ? NR 2E-12 11.699 rs604723 N/A coronary artery disease (EFO:0001645)
 PMID:36474045
GWAS1046882_H GCST90018988 Medication use (agents acting on the renin-angiotensin system) 62,752 European ancestry cases, 174,778 European ancestry controls, 45,820 East Asian ancestry cases, 132,906 East Asian ancestry controls C NR 4E-35 34.398 rs604723 0.0652 Agents acting on the renin-angiotensin system use measurement (EFO:0009931)
 PMID:34594039
None Available GCST90435415 Systolic blood pressure 404,507 European ancestry individuals ? NR 5E-66 65.302 rs604723 0.0372518 systolic blood pressure (EFO:0006335)
 PMID:39134668
None Available GCST90435414 Diastolic blood pressure 404,337 European ancestry individuals ? NR 2E-63 62.699 rs604723 0.0392099 diastolic blood pressure (EFO:0006336)
 PMID:39134668
None Available GCST90446535 Cardiovascular disease 44,238 European ancestry cases, 414,900 European ancestry controls ? NR 8E-9 8.097 rs604723 N/A cardiovascular disease (EFO:0000319)
 PMID:37947095
None Available GCST90446531 Hypertension 193,908 European ancestry cases, 265,230 European ancestry controls ? NR 1E-36 36 rs604723 N/A hypertension (EFO:0000537)
 PMID:37947095
None Available GCST90446534 Coronary heart disease 38,687 European ancestry cases, 420,451 European ancestry controls ? NR 5E-9 8.302 rs604723 N/A coronary artery disease (EFO:0001645)
 PMID:37947095
GWAS1063561_H GCST90245848 Height 5,314,291 European ancestry, Hispanic or Latin American, East Asian ancestry, African ancestry, South Asian ancestry individuals T 0.2901 4E-14 13.398 rs604723 0.0053 body height (EFO:0004339)
 PMID:36224396
GWAS1068211_H GCST90310295 Diastolic blood pressure 1,028,980 European ancestry individuals C NR 4E-85 84.398 rs604723 0.3308 diastolic blood pressure (EFO:0006336)
 PMID:38689001
Database Acc Id Source(s)
GWAS Catalog GCST006167 GWAS Catalog

RGD Curation Notes
Note Type Note Reference