GWAS597484_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS597484_H (eosinophil percentage of leukocytes QTL GWAS597484 (human)) Homo sapiens

Symbol: GWAS597484_H
Name: eosinophil percentage of leukocytes QTL GWAS597484 (human)
RGD ID: 406948508
Trait: eosinophil percentage of leukocytes
Measurement Type: blood eosinophil count to total leukocyte count ratio   (CMO:0000369)    
LOD Score: Not Available
P Value: 7.0E-34
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh381339,781,776 - 39,781,777RGD_MAPPER_PIPELINEGRCh38
GRCh371340,355,913 - 40,355,914RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS597484_HHumanblood eosinophil count to total leukocyte count ratio  IAGPrs9532434405850206Based on the EFO term IDGWAS_CATALOGPMID:32888494

Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS597484_HHumaneosinophil percentage of leukocytes  IAGPrs9532434405850206 GWAS_CATALOGPMID:32888494
Experimental Data Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1346233COG6component of oligomeric golgi complex 6133965562739791666Human

Position Markers

Peak: (rs9532434)
Human AssemblyChrPosition (strand)Source
GRCh381339,781,776 - 39,781,777RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
406954977GWAS603953_Heosinophil count QTL GWAS603953 (human)1e-11eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)133978177639781777Human
407332198GWAS981174_Hrheumatoid arthritis QTL GWAS981174 (human)0.0000002rheumatoid arthritis133978177639781777Human
406967204GWAS616180_Hbasophil count, eosinophil count QTL GWAS616180 (human)1e-10eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)133978177639781777Human
407059748GWAS708724_Heosinophil count QTL GWAS708724 (human)5e-32eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)133978177639781777Human
406964742GWAS613718_Hneutrophil percentage of granulocytes QTL GWAS613718 (human)2e-09neutrophil percentage of granulocytes133978177639781777Human
407320495GWAS969471_Hrheumatoid arthritis, anti-citrullinated protein antibody seropositivity, rheumatoid factor seropositivity measurement QTL GWAS969471 (human)6e-18rheumatoid arthritis, anti-citrullinated protein antibody seropositivity, rheumatoid factor seropositivity measurement133978177639781777Human
406941576GWAS590552_Heosinophil count QTL GWAS590552 (human)5e-38eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)133978177639781777Human
407319723GWAS968699_Hrheumatoid arthritis QTL GWAS968699 (human)9e-22rheumatoid arthritis133978177639781777Human
407229463GWAS878439_Hrheumatoid arthritis, anti-citrullinated protein antibody seropositivity, rheumatoid factor seropositivity measurement QTL GWAS878439 (human)7e-15rheumatoid arthritis, anti-citrullinated protein antibody seropositivity, rheumatoid factor seropositivity measurement133978177639781777Human
406969492GWAS618468_Heosinophil percentage of leukocytes QTL GWAS618468 (human)2e-12eosinophil percentage of leukocytesblood eosinophil count to total leukocyte count ratio (CMO:0000369)133978177639781777Human
406967545GWAS616521_Heosinophil percentage of granulocytes QTL GWAS616521 (human)2e-10eosinophil percentage of granulocytes133978177639781777Human
406948508GWAS597484_Heosinophil percentage of leukocytes QTL GWAS597484 (human)7e-34eosinophil percentage of leukocytesblood eosinophil count to total leukocyte count ratio (CMO:0000369)133978177639781777Human
407319001GWAS967977_Hrheumatoid arthritis QTL GWAS967977 (human)5e-15rheumatoid arthritis133978177639781777Human
406895839GWAS544815_Hsystemic juvenile idiopathic arthritis, polyarticular juvenile idiopathic arthritis, rheumatoid factor negative, oligoarticular juvenile idiopathic arthritis QTL GWAS544815 (human)5e-08systemic juvenile idiopathic arthritis, polyarticular juvenile idiopathic arthritis, rheumatoid factor negative, oligoarticular juvenile idiopathic arthritis133978177639781777Human
407054556GWAS703532_Heosinophil count QTL GWAS703532 (human)8e-36eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)133978177639781777Human
407042525GWAS691501_Hrheumatoid arthritis QTL GWAS691501 (human)2e-19rheumatoid arthritis133978177639781777Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS544815_H GCST005528 Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) 2,816 European ancestry cases, 13,056 European ancestry controls ? 0.64 5E-8 7.302 rs9532434 1.1904762 systemic juvenile idiopathic arthritis (EFO:1001999)
polyarticular juvenile idiopathic arthritis, rheumatoid factor negative (EFO:1002020)
oligoarticular juvenile idiopathic arthritis (EFO:1002019)
 PMID:23603761
GWAS590552_H GCST90002298 Eosinophil counts 474,237 European ancestry individuals C 0.649421 5E-38 37.302 rs9532434 0.026887 eosinophil count (EFO:0004842)
 PMID:32888493
GWAS597484_H GCST90002382 Eosinophil percentage of white cells 408,112 British individuals C 0.64924 7E-34 33.155 rs9532434 0.028296808 eosinophil percentage of leukocytes (EFO:0007991)
 PMID:32888494
GWAS603953_H GCST004606 Eosinophil counts 172,275 European ancestry individuals C 0.6503 1E-11 11 rs9532434 0.02533407 eosinophil count (EFO:0004842)
 PMID:27863252
GWAS613718_H GCST004623 Neutrophil percentage of granulocytes 170,672 European ancestry individuals C 0.6503 2E-9 8.699 rs9532434 0.02241523 neutrophil percentage of granulocytes (EFO:0007994)
 PMID:27863252
GWAS616180_H GCST004624 Sum eosinophil basophil counts 171,771 European ancestry individuals C 0.6503 1E-10 10 rs9532434 0.02403834 basophil count (EFO:0005090)
eosinophil count (EFO:0004842)
 PMID:27863252
GWAS616521_H GCST004617 Eosinophil percentage of granulocytes 170,536 European ancestry individuals C 0.6503 2E-10 9.699 rs9532434 0.0238945 eosinophil percentage of granulocytes (EFO:0007996)
 PMID:27863252
GWAS618468_H GCST004600 Eosinophil percentage of white cells 172,378 European ancestry individuals C 0.6503 2E-12 11.699 rs9532434 0.02640767 eosinophil percentage of leukocytes (EFO:0007991)
 PMID:27863252
GWAS691501_H GCST90013534 Rheumatoid arthritis 14,361 European ancestry cases, 43,923 European ancestry controls, 8,267 East Asian ancestry cases, 244,741 East Asian ancestry controls T NR 2E-19 18.699 rs9532434 0.89 rheumatoid arthritis (EFO:0000685)
 PMID:33310728
GWAS703532_H GCST90002302 Eosinophil counts 583,850 African American or Afro-Caribbean, African ancestry, European ancestry, East Asian ancestry, Hispanic or Latin American and South Asian ancestry individuals C 0.661706 8E-36 35.097 rs9532434 N/A eosinophil count (EFO:0004842)
 PMID:32888493
GWAS708724_H GCST90002381 Eosinophil counts 408,112 British individuals C 0.649252 5E-32 31.302 rs9532434 0.027594073 eosinophil count (EFO:0004842)
 PMID:32888494
GWAS878439_H GCST90132226 Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive) 17,221 European ancestry cases, 74,823 European ancestry controls C 0.6571 7E-15 14.155 rs9532434 1.1254692 rheumatoid arthritis (EFO:0000685)
anti-citrullinated protein antibody seropositivity (EFO:0007837)
rheumatoid factor seropositivity measurement (EFO:0007791)
 PMID:36333501
GWAS967977_H GCST90132223 Rheumatoid arthritis 22,350 European ancestry cases, 74,823 European ancestry controls C 0.6571 5E-15 14.302 rs9532434 1.114382 rheumatoid arthritis (EFO:0000685)
 PMID:36333501
GWAS968699_H GCST90132222 Rheumatoid arthritis 22,350 European ancestry cases, 74,823 European ancestry controls, 11,025 East Asian ancestry cases, 162,608 East Asian ancestry controls, 999 African ancestry cases, 1,108 African ancestry controls, 986 South Asian ancestry cases, 1,258 South Asian ancestry controls, 511 Arab ancestry cases, 352 Arab ancestry controls C NR 9E-22 21.046 rs9532434 1.1114883 rheumatoid arthritis (EFO:0000685)
 PMID:36333501
GWAS969471_H GCST90132225 Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive) 17,221 European ancestry cases, 74,823 European ancestry controls, 8,340 East Asian ancestry cases, 162,608 East Asian ancestry controls, 841 African ancestry cases, 1,108 African ancestry controls, 689 South Asian ancestry cases, 1,258 South Asian ancestry controls, 357 Arab ancestry cases, 352 Arab ancestry controls C NR 6E-18 17.222 rs9532434 1.1153854 rheumatoid arthritis (EFO:0000685)
anti-citrullinated protein antibody seropositivity (EFO:0007837)
rheumatoid factor seropositivity measurement (EFO:0007791)
 PMID:36333501
GWAS981174_H GCST90132224 Rheumatoid arthritis 11,025 East Asian ancestry cases, 162,608 East Asian ancestry controls C 0.7619 2E-7 6.699 rs9532434 1.1070513 rheumatoid arthritis (EFO:0000685)
 PMID:36333501
Database Acc Id Source(s)
GWAS Catalog GCST90002382 GWAS Catalog

RGD Curation Notes
Note Type Note Reference