Tmed11 (transmembrane emp24 protein transport domain containing 11) - Rat Genome Database

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Gene: Tmed11 (transmembrane emp24 protein transport domain containing 11) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Tmed11
Name: transmembrane emp24 protein transport domain containing 11
RGD ID: 1588776
Description: Predicted to be involved in Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum-Golgi intermediate compartment; INTERACTS WITH bisphenol A; sodium dichromate.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: LOC689712; similar to Glycoprotein 25L precursor (GP25L); transmembrane emp24 domain-containing protein 11; transmembrane emp24 protein transport domain containing; transmembrane emp24 protein transport domain containing 4-like
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8141,071,410 - 1,091,793 (+)NCBIGRCr8
mRatBN7.214926,983 - 947,574 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl14927,001 - 947,321 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0141,936,972 - 1,959,089 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl141,937,041 - 1,957,579 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0141,932,659 - 1,953,450 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4141,466,847 - 1,487,827 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera14965,819 - 987,611 (+)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tmed11Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of TMED11 mRNACTDPMID:25181051
Tmed11Ratsodium dichromate decreases expressionEXP 6480464sodium bichromate results in decreased expression of TMED11 mRNACTDPMID:22561333


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tmed11Ratendoplasmic reticulum to Golgi vesicle-mediated transport involved_inIBAFB:FBgn0029709 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tmed11RatGolgi organization involved_inIBAMGI:1915831 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tmed11Ratintracellular protein transport involved_inIBAPANTHER:PTN000516376 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tmed11RatCOPII-coated ER to Golgi transport vesicle is_active_inIBAPANTHER:PTN000516376 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tmed11Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
Tmed11Ratendoplasmic reticulum is_active_inIBAFB:FBgn0264389 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tmed11Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
Tmed11Ratendoplasmic reticulum-Golgi intermediate compartment is_active_inIBAFB:FBgn0061492 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tmed11RatGolgi apparatus is_active_inIBAFB:FBgn0061492 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tmed11Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Tmed11Ratmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


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Variants in Tmed11
94 total Variants

Predicted Target Of
Summary Value
Count of predictions:13
Count of miRNA genes:13
Interacting mature miRNAs:13
Transcripts:ENSRNOT00000000040
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat

D14Got1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8141,083,398 - 1,083,596 (+)Marker Load Pipeline
mRatBN7.214938,989 - 939,366 (+)MAPPERmRatBN7.2
mRatBN7.214938,989 - 939,187 (+)MAPPERmRatBN7.2
Rnor_6.0141,949,012 - 1,949,209NCBIRnor6.0
Rnor_6.0141,949,012 - 1,949,438NCBIRnor6.0
Rnor_5.0141,944,738 - 1,945,164UniSTSRnor5.0
Rnor_5.0141,944,738 - 1,944,935UniSTSRnor5.0
RGSC_v3.4141,479,489 - 1,479,686UniSTSRGSC3.4
RGSC_v3.4141,479,488 - 1,479,686RGDRGSC3.4
RGSC_v3.1141,479,488 - 1,479,686RGD
Celera14977,833 - 978,025UniSTS
RH 2.0 Map149.8RGD
Cytogenetic Map14p22UniSTS
AI178079  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.214946,752 - 946,879 (+)MAPPERmRatBN7.2
Rnor_6.0141,957,011 - 1,957,137NCBIRnor6.0
Rnor_5.0141,952,737 - 1,952,863UniSTSRnor5.0
RGSC_v3.4141,487,259 - 1,487,385UniSTSRGSC3.4
Celera14985,533 - 985,659UniSTS
Cytogenetic Map14p22UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 2 9 31 37 35 15 19 15 5 68 42 17 2 37 20



Ensembl Acc Id: ENSRNOT00000000040   ⟹   ENSRNOP00000000040
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl14927,001 - 947,321 (+)Ensembl
Rnor_6.0 Ensembl141,937,041 - 1,957,579 (+)Ensembl
RefSeq Acc Id: XM_001071744   ⟹   XP_001071744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8141,071,410 - 1,091,793 (+)NCBI
mRatBN7.214926,983 - 947,574 (+)NCBI
Rnor_6.0141,936,972 - 1,959,089 (+)NCBI
Rnor_5.0141,932,659 - 1,953,450 (+)NCBI
RGSC_v3.4141,466,847 - 1,487,827 (+)RGD
Sequence:
Protein RefSeqs NP_001419923 (Get FASTA)   NCBI Sequence Viewer  
  XP_001071744 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000000040
  ENSRNOP00000000040.1
RefSeq Acc Id: XP_001071744   ⟸   XM_001071744
- Sequence:
Ensembl Acc Id: ENSRNOP00000000040   ⟸   ENSRNOT00000000040
GOLD

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZE21-F1-model_v2 AlphaFold D3ZE21 1-214 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699158
Promoter ID:EPDNEW_R9666
Type:single initiation site
Name:Tmed11_1
Description:transmembrane emp24 protein transport domain containing 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0141,936,986 - 1,937,046EPDNEW


1 to 15 of 15 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-16688 BioCyc
Ensembl Genes ENSRNOG00000000035 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000040 ENTREZGENE
  ENSRNOT00000000040.3 UniProtKB/TrEMBL
InterPro GOLD UniProtKB/TrEMBL
  TMP21-related UniProtKB/TrEMBL
KEGG Report rno:689712 UniProtKB/TrEMBL
NCBI Gene 689712 ENTREZGENE
PANTHER PTHR22811 UniProtKB/TrEMBL
Pfam EMP24_GP25L UniProtKB/TrEMBL
PhenoGen Tmed11 PhenoGen
PROSITE GOLD UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000035 RatGTEx
SMART EMP24_GP25L UniProtKB/TrEMBL
UniProt D3ZE21 ENTREZGENE, UniProtKB/TrEMBL
1 to 15 of 15 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Tmed11  transmembrane emp24 protein transport domain containing 11  LOC100363761  transmembrane emp24 protein transport domain containing 4-like  Data merged from RGD:2322390 1643240 APPROVED
2012-02-03 Tmed11  transmembrane emp24 protein transport domain containing 11  Tmed11  transmembrane emp24 protein transport domain containing  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100363761  transmembrane emp24 protein transport domain containing 4-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-02-12 Tmed11  transmembrane emp24 protein transport domain containing  LOC689712  similar to Glycoprotein 25L precursor (GP25L)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC689712  similar to Glycoprotein 25L precursor (GP25L)  LOC682110  similar to Glycoprotein 25L precursor (GP25L)  Data merged from RGD:1586975 1643240 APPROVED
2006-11-19 LOC689712  similar to Glycoprotein 25L precursor (GP25L)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC682110  similar to Glycoprotein 25L precursor (GP25L)      Symbol and Name status set to provisional 70820 PROVISIONAL