MIR548BA (microRNA 548ba) - Rat Genome Database

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Gene: MIR548BA (microRNA 548ba) Homo sapiens
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Symbol: MIR548BA
Name: microRNA 548ba
RGD ID: 8551141
HGNC Page HGNC:50260
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-548ba
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38249,059,603 - 49,059,658 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl249,059,603 - 49,059,658 (+)EnsemblGRCh38hg38GRCh38
GRCh37249,286,742 - 49,286,797 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map2p16.3NCBI
HuRef249,020,543 - 49,020,598 (+)NCBIHuRef
CHM1_1249,217,253 - 49,217,308 (+)NCBICHM1_1
T2T-CHM13v2.0249,055,595 - 49,055,650 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16381832   PMID:23660593   PMID:32042028  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2p21-16.3(chr2:46806218-50565538)x1 copy number loss See cases [RCV000133939] Chr2:46806218..50565538 [GRCh38]
Chr2:47033357..50792676 [GRCh37]
Chr2:46886861..50646180 [NCBI36]
Chr2:2p21-16.3		 pathogenic
GRCh38/hg38 2p16.3-11.2(chr2:47620388-86702722)x3 copy number gain See cases [RCV000137586] Chr2:47620388..86702722 [GRCh38]
Chr2:47847527..86929845 [GRCh37]
Chr2:47701031..86783356 [NCBI36]
Chr2:2p16.3-11.2		 uncertain significance
GRCh38/hg38 2p16.3(chr2:48543380-49241978)x3 copy number gain See cases [RCV000142001] Chr2:48543380..49241978 [GRCh38]
Chr2:48770519..49469117 [GRCh37]
Chr2:48624023..49322621 [NCBI36]
Chr2:2p16.3		 uncertain significance
GRCh38/hg38 2p25.1-11.2(chr2:7495123-87705899)x3 copy number gain See cases [RCV000141494] Chr2:7495123..87705899 [GRCh38]
Chr2:7635254..88005418 [GRCh37]
Chr2:7552705..87786533 [NCBI36]
Chr2:2p25.1-11.2		 benign
GRCh38/hg38 2p16.3(chr2:48929614-50839499)x1 copy number loss See cases [RCV000143016] Chr2:48929614..50839499 [GRCh38]
Chr2:49156753..51066637 [GRCh37]
Chr2:49010257..50920141 [NCBI36]
Chr2:2p16.3		 pathogenic
GRCh38/hg38 2p16.3(chr2:48581695-49195508)x3 copy number gain See cases [RCV000142537] Chr2:48581695..49195508 [GRCh38]
Chr2:48808834..49422647 [GRCh37]
Chr2:48662338..49276151 [NCBI36]
Chr2:2p16.3		 likely benign|uncertain significance
GRCh38/hg38 2p25.3-16.1(chr2:66097-55570637)x3 copy number gain See cases [RCV000052933] Chr2:66097..55570637 [GRCh38]
Chr2:66097..55797773 [GRCh37]
Chr2:56097..55651277 [NCBI36]
Chr2:2p25.3-16.1		 pathogenic
GRCh38/hg38 2p22.1-16.1(chr2:40738282-57863821)x3 copy number gain See cases [RCV000052943] Chr2:40738282..57863821 [GRCh38]
Chr2:40965422..58090956 [GRCh37]
Chr2:40818926..57944460 [NCBI36]
Chr2:2p22.1-16.1		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:12109
Count of gene targets:4660
Count of transcripts:8481
Interacting mature miRNAs:hsa-miR-548ba
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
integumental system
mesenchyme
mesoderm
nervous system
respiratory system
1 5 3 2 9 3 4 6 5 12 9 4 4

Sequence


Ensembl Acc Id: ENST00000390747
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl249,059,603 - 49,059,658 (+)Ensembl
RefSeq Acc Id: NR_107011
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38249,059,603 - 49,059,658 (+)NCBI
HuRef249,020,543 - 49,020,598 (+)NCBI
CHM1_1249,217,253 - 49,217,308 (+)NCBI
T2T-CHM13v2.0249,055,595 - 49,055,650 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR548BA COSMIC
Ensembl Genes ENSG00000212036 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000390747 ENTREZGENE
GTEx ENSG00000212036 GTEx
HGNC ID HGNC:50260 ENTREZGENE
Human Proteome Map MIR548BA Human Proteome Map
miRBase MI0025747 ENTREZGENE
NCBI Gene MIR548BA ENTREZGENE
RNAcentral URS000075BACB RNACentral
  URS000075CC0C RNACentral