MIR6736 (microRNA 6736) - Rat Genome Database

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Gene: MIR6736 (microRNA 6736) Homo sapiens
Analyze
Symbol: MIR6736
Name: microRNA 6736
RGD ID: 8550315
HGNC Page HGNC:50072
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-6736
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381145,850,587 - 145,850,645 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1145,850,587 - 145,850,645 (-)EnsemblGRCh38hg38GRCh38
GRCh371145,584,423 - 145,584,481 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map1q21.1NCBI
HuRef1119,548,161 - 119,548,219 (+)NCBIHuRef
CHM1_11147,218,713 - 147,218,771 (-)NCBICHM1_1
T2T-CHM13v2.01144,967,390 - 144,967,448 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Schizophrenia  (IAGP)
References
Additional References at PubMed
PMID:16381832   PMID:22955976   PMID:34374639  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q21.1-21.2(chr1:145232830-148587578)x3 copy number gain See cases [RCV000133640] Chr1:145232830..148587578 [GRCh38]
Chr1:145987156..148545520 [GRCh37]
Chr1:144698513..146812144 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic|conflicting data from submitters
GRCh38/hg38 1q21.1-21.2(chr1:143965076-149471555)x3 copy number gain See cases [RCV000051832] Chr1:143965076..149471555 [GRCh38]
Chr1:119457515..121050554 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1-21.2(chr1:145215697-149076087)x1 copy number loss See cases [RCV000050689] Chr1:145215697..149076087 [GRCh38]
Chr1:146143189..148545520 [GRCh37]
Chr1:144854546..146812144 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1-21.2(chr1:144572470-149076087)x4 copy number gain See cases [RCV000053172] Chr1:144572470..149076087 [GRCh38]
Chr1:145425395..148867610 [GRCh37]
Chr1:144136752..147134234 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1(chr1:145601946-146009630)x1 copy number loss See cases [RCV000053582] Chr1:145601946..146009630 [GRCh38]
Chr1:145425395..145987215 [GRCh37]
Chr1:144136752..144698572 [NCBI36]
Chr1:1q21.1		 pathogenic
GRCh38/hg38 1q21.1(chr1:145635432-146019857)x3 copy number gain See cases [RCV000134116] Chr1:145635432..146019857 [GRCh38]
Chr1:145415156..145799615 [GRCh37]
Chr1:144126513..144510972 [NCBI36]
Chr1:1q21.1		 conflicting data from submitters
GRCh38/hg38 1q21.1-21.2(chr1:145601946-148572213)x1 copy number loss See cases [RCV000135335] Chr1:145601946..148572213 [GRCh38]
Chr1:145311043..147915048 [GRCh37]
Chr1:144022400..146381672 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1-21.2(chr1:145338382-148599763)x3 copy number gain See cases [RCV000135353] Chr1:145338382..148599763 [GRCh38]
Chr1:145271815..148254822 [GRCh37]
Chr1:143983172..146621446 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1(chr1:145688153-146166380)x3 copy number gain See cases [RCV000135354] Chr1:145688153..146166380 [GRCh38]
Chr1:145271815..145746912 [GRCh37]
Chr1:143983172..144458269 [NCBI36]
Chr1:1q21.1		 pathogenic
GRCh38/hg38 1q21.1(chr1:145439580-147036021)x3 copy number gain See cases [RCV000135720] Chr1:145439580..147036021 [GRCh38]
Chr1:145425395..146507577 [GRCh37]
Chr1:144136752..144974201 [NCBI36]
Chr1:1q21.1		 conflicting interpretations of pathogenicity|conflicting data from submitters
GRCh38/hg38 1q21.1(chr1:145691625-146082575)x3 copy number gain See cases [RCV000135485] Chr1:145691625..146082575 [GRCh38]
Chr1:145311043..145743440 [GRCh37]
Chr1:144022400..144454797 [NCBI36]
Chr1:1q21.1		 likely pathogenic
GRCh38/hg38 1q21.1(chr1:145646117-146019823)x1 copy number loss See cases [RCV000135938] Chr1:145646117..146019823 [GRCh38]
Chr1:145415190..145788922 [GRCh37]
Chr1:144126547..144500279 [NCBI36]
Chr1:1q21.1		 likely pathogenic
GRCh38/hg38 1q21.1-21.2(chr1:145215697-149076087)x3 copy number gain See cases [RCV000137559] Chr1:145215697..149076087 [GRCh38]
Chr1:146053414..148535229 [GRCh37]
Chr1:144764771..146801853 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1(chr1:145601946-146019823)x1 copy number loss See cases [RCV000137671] Chr1:145601946..146019823 [GRCh38]
Chr1:145415190..146053471 [GRCh37]
Chr1:144126547..144764828 [NCBI36]
Chr1:1q21.1		 pathogenic
GRCh38/hg38 1q21.1-21.2(chr1:145232830-148587578)x3 copy number gain See cases [RCV000138437] Chr1:145232830..148587578 [GRCh38]
Chr1:146500972..148535229 [GRCh37]
Chr1:144967596..146801853 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic|conflicting data from submitters
GRCh38/hg38 1q21.1-21.2(chr1:145215697-149076087)x4 copy number gain See cases [RCV000138438] Chr1:145215697..149076087 [GRCh38]
Chr1:146500972..148535229 [GRCh37]
Chr1:144967596..146801853 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1(chr1:145601946-146046631)x1 copy number loss See cases [RCV000139546] Chr1:145601946..146046631 [GRCh38]
Chr1:145388369..145899418 [GRCh37]
Chr1:144099726..144610775 [NCBI36]
Chr1:1q21.1		 pathogenic
GRCh38/hg38 1q21.1-21.2(chr1:145601946-148572213)x1 copy number loss See cases [RCV000141206] Chr1:145601946..148572213 [GRCh38]
Chr1:145376675..147860552 [GRCh37]
Chr1:144088032..146327176 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1(chr1:145601946-146052881)x1 copy number loss See cases [RCV000141815] Chr1:145601946..146052881 [GRCh38]
Chr1:145382123..145888926 [GRCh37]
Chr1:144093480..144600283 [NCBI36]
Chr1:1q21.1		 likely benign
GRCh38/hg38 1q21.1-21.2(chr1:145215697-149076087)x1 copy number loss See cases [RCV000142511] Chr1:145215697..149076087 [GRCh38]
Chr1:145655992..148545520 [GRCh37]
Chr1:144367349..146812144 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1-21.2(chr1:145215697-149076087)x1 copy number loss See cases [RCV000142480] Chr1:145215697..149076087 [GRCh38]
Chr1:146507649..148545664 [GRCh37]
Chr1:144974273..146812288 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1(chr1:145642988-146047980)x1 copy number loss See cases [RCV000142207] Chr1:145642988..146047980 [GRCh38]
Chr1:145387023..145792052 [GRCh37]
Chr1:144098380..144503409 [NCBI36]
Chr1:1q21.1		 uncertain significance
GRCh38/hg38 1q21.1-21.2(chr1:145215697-149076087)x3 copy number gain See cases [RCV000142804] Chr1:145215697..149076087 [GRCh38]
Chr1:146526310..148535229 [GRCh37]
Chr1:144992934..146801853 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1-21.2(chr1:145215697-149076087)x3 copy number gain See cases [RCV000142666] Chr1:145215697..149076087 [GRCh38]
Chr1:146571304..148545520 [GRCh37]
Chr1:145037928..146812144 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1(chr1:145601946-146065803)x1 copy number loss See cases [RCV000143222] Chr1:145601946..146065803 [GRCh38]
Chr1:145369199..145888926 [GRCh37]
Chr1:144080556..144600283 [NCBI36]
Chr1:1q21.1		 likely pathogenic
GRCh38/hg38 1q21.1(chr1:145635445-146009630)x3 copy number gain See cases [RCV000148088] Chr1:145635445..146009630 [GRCh38]
Chr1:145425395..145799602 [GRCh37]
Chr1:144136752..144510959 [NCBI36]
Chr1:1q21.1		 uncertain significance
GRCh38/hg38 1q21.1(chr1:145635445-146009630)x1 copy number loss See cases [RCV000148089] Chr1:145635445..146009630 [GRCh38]
Chr1:145425395..145799602 [GRCh37]
Chr1:144136752..144510959 [NCBI36]
Chr1:1q21.1		 pathogenic
GRCh38/hg38 1q21.1-21.2(chr1:143515074-149076087)x1 copy number loss See cases [RCV000148052] Chr1:143515074..149076087 [GRCh38]
Chr1:145655992..149232481 [GRCh37]
Chr1:144367349..147499105 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1(chr1:145605589-146057729)x1 copy number loss See cases [RCV000143601] Chr1:145605589..146057729 [GRCh38]
Chr1:145377276..145829474 [GRCh37]
Chr1:144088633..144540831 [NCBI36]
Chr1:1q21.1		 uncertain significance
GRCh38/hg38 1q21.1(chr1:145705541-146009831)x1 copy number loss See cases [RCV000148151] Chr1:145705541..146009831 [GRCh38]
Chr1:145425195..145729525 [GRCh37]
Chr1:144136552..144440882 [NCBI36]
Chr1:1q21.1		 pathogenic
GRCh38/hg38 1q21.1-21.2(chr1:145215697-149076087)x3 copy number gain See cases [RCV000148163] Chr1:145215697..149076087 [GRCh38]
Chr1:146143189..148545520 [GRCh37]
Chr1:144854546..146812144 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1(chr1:145601946-146009630)x3 copy number gain See cases [RCV000148171] Chr1:145601946..146009630 [GRCh38]
Chr1:145425395..145987215 [GRCh37]
Chr1:144136752..144698572 [NCBI36]
Chr1:1q21.1		 uncertain significance
GRCh38/hg38 1q21.1-21.2(chr1:145215697-149076087)x1 copy number loss See cases [RCV000148183] Chr1:145215697..149076087 [GRCh38]
Chr1:145987156..148545520 [GRCh37]
Chr1:144698513..146812144 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1(chr1:145635445-146009630)x3 copy number gain See cases [RCV000050972] Chr1:145635445..146009630 [GRCh38]
Chr1:145425395..145799602 [GRCh37]
Chr1:144136752..144510959 [NCBI36]
Chr1:1q21.1		 benign|uncertain significance|conflicting data from submitters
GRCh38/hg38 1q21.1-21.2(chr1:145439580-148359881)x1 copy number loss See cases [RCV000050516] Chr1:145439580..148359881 [GRCh38]
Chr1:145425395..147909094 [GRCh37]
Chr1:144136752..146375718 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic|uncertain significance|conflicting data from submitters
GRCh38/hg38 1q21.1-21.2(chr1:145215697-149076087)x3 copy number gain See cases [RCV000050868] Chr1:145215697..149076087 [GRCh38]
Chr1:145799543..148545520 [GRCh37]
Chr1:144510900..146812144 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1-21.2(chr1:145215697-149076087)x3 copy number gain See cases [RCV000050688] Chr1:145215697..149076087 [GRCh38]
Chr1:146143189..148545520 [GRCh37]
Chr1:144854546..146812144 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic|likely pathogenic|conflicting interpretations of pathogenicity|conflicting data from submitters
GRCh38/hg38 1q21.1-21.2(chr1:145215697-149076087)x1 copy number loss See cases [RCV000050278] Chr1:145215697..149076087 [GRCh38]
Chr1:145987156..148545520 [GRCh37]
Chr1:144698513..146812144 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1p11.2-q22(chr1:120836007-149583533)x3 copy number gain See cases [RCV000051109] Chr1:120836007..149583533 [GRCh38]
Chr1:145451329..156102366 [GRCh37]
Chr1:144162686..154368990 [NCBI36]
Chr1:1p11.2-q22		 pathogenic
GRCh38/hg38 1q21.1(chr1:145705541-146009831)x1 copy number loss See cases [RCV000052241] Chr1:145705541..146009831 [GRCh38]
Chr1:145425195..145729525 [GRCh37]
Chr1:144136552..144440882 [NCBI36]
Chr1:1q21.1		 pathogenic|uncertain significance|conflicting data from submitters
GRCh38/hg38 1q21.1-21.2(chr1:145215697-148534530)x1 copy number loss See cases [RCV000052244] Chr1:145215697..148534530 [GRCh38]
Chr1:145451329..148309094 [GRCh37]
Chr1:144162686..146675718 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1-21.2(chr1:145601946-146944906)x1 copy number loss See cases [RCV000052251] Chr1:145601946..146944906 [GRCh38]
Chr1:145787561..147800872 [GRCh37]
Chr1:144498918..146267496 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1-21.2(chr1:145215697-149076087)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052297]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052297]|See cases [RCV000052297] Chr1:145215697..149076087 [GRCh38]
Chr1:146143189..148545535 [GRCh37]
Chr1:144854546..146812159 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1p12-q21.2(chr1:120836007-149583533)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051844]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051844]|See cases [RCV000051844] Chr1:120836007..149583533 [GRCh38]
Chr1:145425395..153212501 [GRCh37]
Chr1:144136752..151479125 [NCBI36]
Chr1:1p12-q21.2		 pathogenic
GRCh38/hg38 1q21.1(chr1:145335791-146133507)x1 copy number loss See cases [RCV000053732] Chr1:145335791..146133507 [GRCh38]
Chr1:145304668..145738275 [GRCh37]
Chr1:144016025..144449632 [NCBI36]
Chr1:1q21.1		 pathogenic
GRCh38/hg38 1q21.1-21.2(chr1:145215697-148492647)x3 copy number gain See cases [RCV000053170] Chr1:145215697..148492647 [GRCh38]
Chr1:145388356..148216139 [GRCh37]
Chr1:144099713..146582763 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1-21.2(chr1:145215697-149076087)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053171]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053171]|See cases [RCV000053171]|See cases [RCV000509068] Chr1:145215697..149076087 [GRCh38]
Chr1:145425395..148545520 [GRCh37]
Chr1:144136752..146812144 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic|likely pathogenic|conflicting data from submitters
GRCh38/hg38 1q21.1-21.2(chr1:144572470-149076087)x4 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053173]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053173]|See cases [RCV000053173] Chr1:144572470..149076087 [GRCh38]
Chr1:145425395..148936712 [GRCh37]
Chr1:144136752..147203336 [NCBI36]
Chr1:1q21.1-21.2		 uncertain significance
GRCh38/hg38 1q21.1(chr1:145688094-146046645)x1 copy number loss See cases [RCV000053735] Chr1:145688094..146046645 [GRCh38]
Chr1:145388355..145746971 [GRCh37]
Chr1:144099712..144458328 [NCBI36]
Chr1:1q21.1		 pathogenic
GRCh38/hg38 1q21.1(chr1:145601946-146046645)x1 copy number loss See cases [RCV000053738] Chr1:145601946..146046645 [GRCh38]
Chr1:145388355..145917640 [GRCh37]
Chr1:144099712..144628997 [NCBI36]
Chr1:1q21.1		 pathogenic
GRCh38/hg38 1q21.1(chr1:145609216-146046645)x1 copy number loss See cases [RCV000053739] Chr1:145609216..146046645 [GRCh38]
Chr1:145388355..145825847 [GRCh37]
Chr1:144099712..144537204 [NCBI36]
Chr1:1q21.1		 pathogenic
GRCh38/hg38 1q21.1(chr1:145635445-146046645)x1 copy number loss See cases [RCV000053740] Chr1:145635445..146046645 [GRCh38]
Chr1:145388355..145799602 [GRCh37]
Chr1:144099712..144510959 [NCBI36]
Chr1:1q21.1		 pathogenic
GRCh38/hg38 1q21.1(chr1:145625047-146021303)x1 copy number loss See cases [RCV000053742] Chr1:145625047..146021303 [GRCh38]
Chr1:145413710..145810009 [GRCh37]
Chr1:144125067..144521366 [NCBI36]
Chr1:1q21.1		 pathogenic
GRCh38/hg38 1q21.1-21.2(chr1:144572470-149076087)x3 copy number gain See cases [RCV000053185] Chr1:144572470..149076087 [GRCh38]
Chr1:145746912..148752268 [GRCh37]
Chr1:144458269..147018892 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1-21.2(chr1:144572470-149076087)x3 copy number gain See cases [RCV000053187] Chr1:144572470..149076087 [GRCh38]
Chr1:145764368..148752268 [GRCh37]
Chr1:144475725..147018892 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1-21.2(chr1:145601946-146944906)x3 copy number gain See cases [RCV000053188] Chr1:145601946..146944906 [GRCh38]
Chr1:145764368..147718449 [GRCh37]
Chr1:144475725..146185073 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1-21.2(chr1:145601946-146944906)x3 copy number gain See cases [RCV000053189] Chr1:145601946..146944906 [GRCh38]
Chr1:145764368..147800872 [GRCh37]
Chr1:144475725..146267496 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1-21.2(chr1:145215697-149076087)x3 copy number gain See cases [RCV000053191] Chr1:145215697..149076087 [GRCh38]
Chr1:145764368..148346383 [GRCh37]
Chr1:144475725..146713007 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1-21.2(chr1:145215697-149076087)x3 copy number gain See cases [RCV000053203] Chr1:145215697..149076087 [GRCh38]
Chr1:146142989..148545676 [GRCh37]
Chr1:144854346..146812300 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1(chr1:145833599-146009630)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053545]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053545]|See cases [RCV000053545] Chr1:145833599..146009630 [GRCh38]
Chr1:145425395..145601513 [GRCh37]
Chr1:144136752..144312870 [NCBI36]
Chr1:1q21.1		 uncertain significance
GRCh38/hg38 1q21.1(chr1:145635445-145968427)x3 copy number gain See cases [RCV000053546] Chr1:145635445..145968427 [GRCh38]
Chr1:145466663..145799602 [GRCh37]
Chr1:144178020..144510959 [NCBI36]
Chr1:1q21.1		 uncertain significance
GRCh38/hg38 1q21.1(chr1:145335791-146146477)x3 copy number gain See cases [RCV000053579] Chr1:145335791..146146477 [GRCh38]
Chr1:145291698..146037042 [GRCh37]
Chr1:144003055..144748399 [NCBI36]
Chr1:1q21.1		 uncertain significance
GRCh38/hg38 1q21.1(chr1:145335791-146127929)x3 copy number gain See cases [RCV000053580] Chr1:145335791..146127929 [GRCh38]
Chr1:145310253..145899398 [GRCh37]
Chr1:144021610..144610755 [NCBI36]
Chr1:1q21.1		 uncertain significance
GRCh38/hg38 1q21.1(chr1:145601946-146009630)x3 copy number gain See cases [RCV000053581] Chr1:145601946..146009630 [GRCh38]
Chr1:145425395..145987215 [GRCh37]
Chr1:144136752..144698572 [NCBI36]
Chr1:1q21.1		 uncertain significance
GRCh38/hg38 1q21.1-21.2(chr1:145335791-146944906)x1 copy number loss See cases [RCV000053728] Chr1:145335791..146944906 [GRCh38]
Chr1:145271814..147848311 [GRCh37]
Chr1:143983171..146314935 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1(chr1:145635445-146009630)x1 copy number loss See cases [RCV000050973] Chr1:145635445..146009630 [GRCh38]
Chr1:145425395..145799602 [GRCh37]
Chr1:144136752..144510959 [NCBI36]
Chr1:1q21.1		 pathogenic|conflicting interpretations of pathogenicity|conflicting data from submitters
GRCh38/hg38 1q21.1-21.2(chr1:143515074-149076087)x1 copy number loss See cases [RCV000052248] Chr1:143515074..149076087 [GRCh38]
Chr1:145655992..149232481 [GRCh37]
Chr1:144367349..147499105 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1(chr1:145138148-146401981)x1 copy number loss See cases [RCV000134757] Chr1:145138148..146401981 [GRCh38]
Chr1:149155041..149699396 [GRCh37]
Chr1:147421665..147966020 [NCBI36]
Chr1:1q21.1		 benign
GRCh38/hg38 1q21.1-21.2(chr1:144572470-149076087)x3 copy number gain See cases [RCV000136047] Chr1:144572470..149076087 [GRCh38]
Chr1:145799556..148867640 [GRCh37]
Chr1:144510913..147134264 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1-21.2(chr1:143515074-149076087)x3 copy number gain See cases [RCV000136866] Chr1:143515074..149076087 [GRCh38]
Chr1:145425395..149091187 [GRCh37]
Chr1:144136752..147357811 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1-21.2(chr1:143515074-149076087)x1 copy number loss See cases [RCV000137435] Chr1:143515074..149076087 [GRCh38]
Chr1:145626237..149244468 [GRCh37]
Chr1:144337594..147511092 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1-21.2(chr1:144572470-149076087)x3 copy number gain See cases [RCV000137646] Chr1:144572470..149076087 [GRCh38]
Chr1:145788863..148809863 [GRCh37]
Chr1:144500220..147076487 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1-21.2(chr1:143515074-149563337)x1 copy number loss See cases [RCV000139762] Chr1:143515074..149563337 [GRCh38]
Chr1:145415156..149433207 [GRCh37]
Chr1:144126513..147699831 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1-21.2(chr1:144572470-149076087)x1 copy number loss See cases [RCV000140697] Chr1:144572470..149076087 [GRCh38]
Chr1:145415190..148809863 [GRCh37]
Chr1:144126547..147076487 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1-21.2(chr1:143515074-149076087)x1 copy number loss See cases [RCV000141560] Chr1:143515074..149076087 [GRCh38]
Chr1:145747242..149155026 [GRCh37]
Chr1:144458599..147421650 [NCBI36]
Chr1:1q21.1-21.2		 pathogenic
GRCh38/hg38 1q21.1-21.2(chr1:144572470-149076087)x1 copy number loss See cases [RCV000141565] Chr1:144572470..149076087 [GRCh38]
Chr1:146500972..148809863 [GRCh37]
Chr1:144967596..147076487 [NCBI36]
Chr1:1q21.1-21.2		 likely pathogenic
NC_000001.11:g.(?_145430995)_(148257619_?)del deletion Schizophrenia [RCV000754126] Chr1:145430995..148257619 [GRCh38]
Chr1:1q21.1-21.2		 pathogenic
NC_000001.11:g.(?_145430995)_(148427734_?)del deletion Schizophrenia [RCV000754127] Chr1:145430995..148427734 [GRCh38]
Chr1:1q21.1-21.2		 pathogenic
NC_000001.11:g.(?_145580669)_(149095000_?)del deletion Schizophrenia [RCV000754128] Chr1:145580669..149095000 [GRCh38]
Chr1:1q21.1-21.2		 pathogenic
Single allele duplication Schizophrenia [RCV000754132] Chr1:145601945..148889374 [GRCh38]
Chr1:1q21.1-21.2		 likely pathogenic
Single allele duplication Schizophrenia [RCV000754129] Chr1:145601945..146041785 [GRCh38]
Chr1:1q21.1		 likely pathogenic
NC_000001.11:g.(?_145601945)_(146048346_?)del deletion Schizophrenia [RCV000754130] Chr1:145601945..146048346 [GRCh38]
Chr1:1q21.1		 likely pathogenic
Single allele duplication Schizophrenia [RCV000754131] Chr1:145601945..146049618 [GRCh38]
Chr1:1q21.1		 likely pathogenic
NC_000001.11:g.145601946_148597425del deletion Radial aplasia-thrombocytopenia syndrome [RCV000853559] Chr1:145601946..148597425 [GRCh38]
Chr1:1q21.1-21.2		 likely pathogenic
GRCh38/hg38 1q21.1(chr1:145635432-146019857) copy number loss See cases [RCV003223552] Chr1:145635432..146019857 [GRCh38]
Chr1:1q21.1		 uncertain significance
GRCh38/hg38 1q21.1(chr1:145822587-146064587)x1 copy number loss Radial aplasia-thrombocytopenia syndrome [RCV003327647] Chr1:145822587..146064587 [GRCh38]
Chr1:1q21.1		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:52718
Count of gene targets:17565
Count of transcripts:40505
Interacting mature miRNAs:hsa-miR-6736-3p, hsa-miR-6736-5p
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357381BW57_HBody weight QTL 57 (human)10.0001Body weightfat free mass after exercise training1140630236166630236Human


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
5 53 24 26 108 35 110 15 90 14 46 197 142 30 80 39 54 93 5

Sequence


Ensembl Acc Id: ENST00000616799
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1145,850,587 - 145,850,645 (-)Ensembl
RefSeq Acc Id: NR_106794
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381145,850,587 - 145,850,645 (-)NCBI
HuRef1119,548,161 - 119,548,219 (+)NCBI
CHM1_11147,218,713 - 147,218,771 (-)NCBI
T2T-CHM13v2.01144,967,390 - 144,967,448 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR6736 COSMIC
Ensembl Genes ENSG00000278549 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000616799 ENTREZGENE
GTEx ENSG00000278549 GTEx
HGNC ID HGNC:50072 ENTREZGENE
Human Proteome Map MIR6736 Human Proteome Map
miRBase MI0022581 ENTREZGENE
NCBI Gene MIR6736 ENTREZGENE
RNAcentral URS0000759B63 RNACentral
  URS000075A2B8 RNACentral
  URS000075E9A6 RNACentral