MIR5193 (microRNA 5193) - Rat Genome Database

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Gene: MIR5193 (microRNA 5193) Homo sapiens
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Symbol: MIR5193
Name: microRNA 5193
RGD ID: 6483930
HGNC Page HGNC:43534
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-5193
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38349,806,137 - 49,806,245 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl349,806,137 - 49,806,245 (-)EnsemblGRCh38hg38GRCh38
GRCh37349,843,570 - 49,843,678 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map3p21.31NCBI
HuRef349,902,620 - 49,902,728 (-)NCBIHuRef
CHM1_1349,795,631 - 49,795,739 (-)NCBICHM1_1
T2T-CHM13v2.0349,836,015 - 49,836,123 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:21037258   PMID:21606961   PMID:26456535   PMID:30608062   PMID:32823233   PMID:37248611  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3p21.31-21.2(chr3:45879883-50749922)x4 copy number gain See cases [RCV000133650] Chr3:45879883..50749922 [GRCh38]
Chr3:45921375..50787353 [GRCh37]
Chr3:45896379..50762357 [NCBI36]
Chr3:3p21.31-21.2		 pathogenic
GRCh38/hg38 3p21.31-14.3(chr3:49461000-55314500)x1 copy number loss See cases [RCV000051511] Chr3:49461000..55314500 [GRCh38]
Chr3:49498433..55348528 [GRCh37]
Chr3:49473437..55323568 [NCBI36]
Chr3:3p21.31-14.3		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:34082
Count of gene targets:12814
Count of transcripts:27541
Interacting mature miRNAs:hsa-miR-5193
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298487BFD1_HBody fluid distribution QTL 1 (human)3.94Body fluid distributionimpedance ratio33638071262380712Human
1298489RA4_HRheumatoid arthritis QTL 4 (human)0.0283Joint/bone inflammationrheumatoid arthritis33638071262380712Human
1643509BW293_HBody Weight QTL 293 (human)1.42Body weightBMI33638071262380712Human
2289308BW392_HBody weight QTL 392 (human)1.42Body weightBMI33638071262380712Human
1331643COPD16_HChronic obstructive pulmonary disease QTL 16 (human)1.07Chronic airflow obstructionpost-BD FEV1 minus pre-BD FEV1/pre-BD FEV1 x 10034938065175380651Human


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
562 1145 886 843 1311 800 1119 187 796 93 750 2581 2706 1114 351 796 839 94

Sequence


Ensembl Acc Id: ENST00000584510
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl349,806,137 - 49,806,245 (-)Ensembl
RefSeq Acc Id: NR_049825
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38349,806,137 - 49,806,245 (-)NCBI
GRCh37349,843,570 - 49,843,678 (-)NCBI
HuRef349,902,620 - 49,902,728 (-)NCBI
CHM1_1349,795,631 - 49,795,739 (-)NCBI
T2T-CHM13v2.0349,836,015 - 49,836,123 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR5193 COSMIC
Ensembl Genes ENSG00000283726 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000584510 ENTREZGENE
GTEx ENSG00000283726 GTEx
HGNC ID HGNC:43534 ENTREZGENE
Human Proteome Map MIR5193 Human Proteome Map
miRBase MI0018172 ENTREZGENE
NCBI Gene MIR5193 ENTREZGENE
RNAcentral URS0000224AEA RNACentral
  URS000075E648 RNACentral