TRIM49B (tripartite motif containing 49B) - Rat Genome Database

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Gene: TRIM49B (tripartite motif containing 49B) Homo sapiens
Analyze
Symbol: TRIM49B
Name: tripartite motif containing 49B
RGD ID: 6483615
HGNC Page HGNC:42955
Description: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Predicted to be active in cytoplasm.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: putative tripartite motif-containing protein 49B; RING finger protein 18B; tripartite motif-containing protein
RGD Orthologs
Bonobo
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381149,028,823 - 49,038,155 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1149,027,501 - 49,038,451 (+)EnsemblGRCh38hg38GRCh38
GRCh371149,050,375 - 49,059,707 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361149,005,629 - 49,016,579 (+)NCBINCBI36Build 36hg18NCBI36
Celera1149,201,744 - 49,242,209 (+)NCBICelera
Cytogenetic Map11p11.12ENTREZGENE
HuRef1148,771,197 - 48,777,572 (+)ENTREZGENEHuRef
CHM1_11149,051,586 - 49,057,934 (+)NCBICHM1_1
T2T-CHM13v2.01149,205,976 - 49,215,304 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21873635   PMID:22144910  


Genomics

Comparative Map Data
TRIM49B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381149,028,823 - 49,038,155 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1149,027,501 - 49,038,451 (+)EnsemblGRCh38hg38GRCh38
GRCh371149,050,375 - 49,059,707 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361149,005,629 - 49,016,579 (+)NCBINCBI36Build 36hg18NCBI36
Celera1149,201,744 - 49,242,209 (+)NCBICelera
Cytogenetic Map11p11.12ENTREZGENE
HuRef1148,771,197 - 48,777,572 (+)ENTREZGENEHuRef
CHM1_11149,051,586 - 49,057,934 (+)NCBICHM1_1
T2T-CHM13v2.01149,205,976 - 49,215,304 (+)NCBIT2T-CHM13v2.0
LOC117974915
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2951,173,344 - 51,179,805 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11151,206,680 - 51,213,109 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01148,914,741 - 48,921,171 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3

Variants

.
Variants in TRIM49B
44 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11p12-11.12(chr11:39179252-49135735)x1 copy number loss See cases [RCV000137391] Chr11:39179252..49135735 [GRCh38]
Chr11:39200802..49157287 [GRCh37]
Chr11:39157378..49113863 [NCBI36]
Chr11:11p12-11.12		 pathogenic
GRCh38/hg38 11p12-11.12(chr11:42727555-49135735)x3 copy number gain See cases [RCV000139422] Chr11:42727555..49135735 [GRCh38]
Chr11:42749105..49157287 [GRCh37]
Chr11:42705681..49113863 [NCBI36]
Chr11:11p12-11.12		 likely pathogenic
GRCh38/hg38 11p11.2-11.12(chr11:47992987-49135735)x3 copy number gain See cases [RCV000139453] Chr11:47992987..49135735 [GRCh38]
Chr11:48014539..49157287 [GRCh37]
Chr11:47971115..49113863 [NCBI36]
Chr11:11p11.2-11.12		 likely benign|uncertain significance
GRCh38/hg38 11p11.12(chr11:48946095-50560016)x1 copy number loss See cases [RCV000141835] Chr11:48946095..50560016 [GRCh38]
Chr11:48967647..50519187 [GRCh37]
Chr11:48924223..50475763 [NCBI36]
Chr11:11p11.12		 uncertain significance
GRCh37/hg19 11p14.2-11.12(chr11:26574629-50508019)x3 copy number gain See cases [RCV000448603] Chr11:26574629..50508019 [GRCh37]
Chr11:11p14.2-11.12		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p11.2-11.12(chr11:48149532-49434855)x3 copy number gain See cases [RCV000511753] Chr11:48149532..49434855 [GRCh37]
Chr11:11p11.2-11.12		 uncertain significance
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p11.2-11.12(chr11:48116066-49170890)x3 copy number gain not provided [RCV000683353] Chr11:48116066..49170890 [GRCh37]
Chr11:11p11.2-11.12		 likely benign
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p11.2-11.12(chr11:48328562-51591253)x3 copy number gain not provided [RCV000737515] Chr11:48328562..51591253 [GRCh37]
Chr11:11p11.2-11.12		 benign
GRCh37/hg19 11p11.2-11.12(chr11:48331739-51581408)x3 copy number gain not provided [RCV000737516] Chr11:48331739..51581408 [GRCh37]
Chr11:11p11.2-11.12		 benign
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p11.2-11.12(chr11:48375604-50345390)x3 copy number gain not provided [RCV000750039] Chr11:48375604..50345390 [GRCh37]
Chr11:11p11.2-11.12		 benign
GRCh37/hg19 11p11.2-11.12(chr11:48735614-50517487)x3 copy number gain not provided [RCV000750041] Chr11:48735614..50517487 [GRCh37]
Chr11:11p11.2-11.12		 benign
GRCh37/hg19 11p11.2-11.12(chr11:48748775-51593877)x3 copy number gain not provided [RCV000750042] Chr11:48748775..51593877 [GRCh37]
Chr11:11p11.2-11.12		 benign
GRCh37/hg19 11p11.12(chr11:48825740-50477559)x3 copy number gain not provided [RCV000750043] Chr11:48825740..50477559 [GRCh37]
Chr11:11p11.12		 benign
GRCh37/hg19 11p11.12(chr11:48901075-50297005)x3 copy number gain not provided [RCV000750044] Chr11:48901075..50297005 [GRCh37]
Chr11:11p11.12		 benign
GRCh37/hg19 11p11.12(chr11:48901075-50477559)x3 copy number gain not provided [RCV000750045] Chr11:48901075..50477559 [GRCh37]
Chr11:11p11.12		 benign
GRCh37/hg19 11p11.12(chr11:48901075-50487842)x3 copy number gain not provided [RCV000750046] Chr11:48901075..50487842 [GRCh37]
Chr11:11p11.12		 benign
GRCh37/hg19 11p11.12(chr11:48901075-50517487)x3 copy number gain not provided [RCV000750047] Chr11:48901075..50517487 [GRCh37]
Chr11:11p11.12		 benign
GRCh37/hg19 11p11.12(chr11:49013685-50278170)x3 copy number gain not provided [RCV000750048] Chr11:49013685..50278170 [GRCh37]
Chr11:11p11.12		 benign
GRCh37/hg19 11p11.12(chr11:49013685-50382437)x3 copy number gain not provided [RCV000750049] Chr11:49013685..50382437 [GRCh37]
Chr11:11p11.12		 benign
NM_001206626.2(TRIM49B):c.1A>G (p.Met1Val) single nucleotide variant not provided [RCV000956940] Chr11:49031600 [GRCh38]
Chr11:49053152 [GRCh37]
Chr11:11p11.12		 benign
GRCh37/hg19 11p11.2-11.12(chr11:48242702-49562051)x3 copy number gain not provided [RCV001259095] Chr11:48242702..49562051 [GRCh37]
Chr11:11p11.2-11.12		 likely benign
NM_001206626.2(TRIM49B):c.1223G>C (p.Arg408Pro) single nucleotide variant not specified [RCV004684730] Chr11:49037841 [GRCh38]
Chr11:49059393 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.894T>A (p.Ser298Arg) single nucleotide variant not specified [RCV004684727] Chr11:49037512 [GRCh38]
Chr11:49059064 [GRCh37]
Chr11:11p11.12		 uncertain significance
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3		 pathogenic
NM_001206626.2(TRIM49B):c.945T>A (p.His315Gln) single nucleotide variant not specified [RCV004327533] Chr11:49037563 [GRCh38]
Chr11:49059115 [GRCh37]
Chr11:11p11.12		 uncertain significance
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3 copy number gain MISSED ABORTION [RCV002282973] Chr11:32799481..134938470 [GRCh37]
Chr11:11p13-q25		 pathogenic
GRCh37/hg19 11p11.2-q12.2(chr11:51581311-54891247)x3 copy number gain See cases [RCV002286338] Chr11:51581311..54891247 [GRCh37]
Chr11:11p11.2-q12.2		 pathogenic
NM_001206626.2(TRIM49B):c.446A>G (p.Glu149Gly) single nucleotide variant not specified [RCV004684729] Chr11:49032310 [GRCh38]
Chr11:49053862 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.724G>A (p.Val242Met) single nucleotide variant not specified [RCV004098899] Chr11:49034362 [GRCh38]
Chr11:49055914 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.1096A>G (p.Asn366Asp) single nucleotide variant not specified [RCV004147957] Chr11:49037714 [GRCh38]
Chr11:49059266 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.1033G>T (p.Val345Phe) single nucleotide variant not specified [RCV004188293] Chr11:49037651 [GRCh38]
Chr11:49059203 [GRCh37]
Chr11:11p11.12		 likely benign
NM_001206626.2(TRIM49B):c.787C>T (p.Pro263Ser) single nucleotide variant not specified [RCV004189968] Chr11:49036326 [GRCh38]
Chr11:49057878 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.857G>A (p.Arg286Gln) single nucleotide variant not specified [RCV004085479] Chr11:49036396 [GRCh38]
Chr11:49057948 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.462T>A (p.Asn154Lys) single nucleotide variant not specified [RCV004181642] Chr11:49032326 [GRCh38]
Chr11:49053878 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.1174T>G (p.Phe392Val) single nucleotide variant not specified [RCV004136968] Chr11:49037792 [GRCh38]
Chr11:49059344 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.740C>G (p.Ala247Gly) single nucleotide variant not specified [RCV004213201] Chr11:49035096 [GRCh38]
Chr11:49056648 [GRCh37]
Chr11:11p11.12		 likely benign
NM_001206626.2(TRIM49B):c.61T>C (p.Tyr21His) single nucleotide variant not specified [RCV004082573] Chr11:49031660 [GRCh38]
Chr11:49053212 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.223T>C (p.Ser75Pro) single nucleotide variant not specified [RCV004161450] Chr11:49031822 [GRCh38]
Chr11:49053374 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.1063T>C (p.Phe355Leu) single nucleotide variant not specified [RCV004140283] Chr11:49037681 [GRCh38]
Chr11:49059233 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.364C>T (p.Arg122Trp) single nucleotide variant not specified [RCV004238920] Chr11:49031963 [GRCh38]
Chr11:49053515 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.13A>G (p.Ile5Val) single nucleotide variant not specified [RCV004235204] Chr11:49031612 [GRCh38]
Chr11:49053164 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.475A>G (p.Asn159Asp) single nucleotide variant not specified [RCV004187294] Chr11:49032339 [GRCh38]
Chr11:49053891 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.927G>A (p.Met309Ile) single nucleotide variant not specified [RCV004239984] Chr11:49037545 [GRCh38]
Chr11:49059097 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.686T>C (p.Met229Thr) single nucleotide variant not specified [RCV004157342] Chr11:49034324 [GRCh38]
Chr11:49055876 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.1132T>G (p.Phe378Val) single nucleotide variant not specified [RCV004122070] Chr11:49037750 [GRCh38]
Chr11:49059302 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.986T>C (p.Leu329Pro) single nucleotide variant not specified [RCV004120571] Chr11:49037604 [GRCh38]
Chr11:49059156 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.937T>C (p.Cys313Arg) single nucleotide variant not specified [RCV004222387] Chr11:49037555 [GRCh38]
Chr11:49059107 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.351C>G (p.Ser117Arg) single nucleotide variant not specified [RCV004278110] Chr11:49031950 [GRCh38]
Chr11:49053502 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.1354T>C (p.Phe452Leu) single nucleotide variant not specified [RCV004256093] Chr11:49037972 [GRCh38]
Chr11:49059524 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.595G>A (p.Glu199Lys) single nucleotide variant not specified [RCV004684726] Chr11:49034233 [GRCh38]
Chr11:49055785 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.392C>T (p.Ser131Leu) single nucleotide variant not specified [RCV004684728] Chr11:49031991 [GRCh38]
Chr11:49053543 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.632G>A (p.Arg211Gln) single nucleotide variant not specified [RCV004335423] Chr11:49034270 [GRCh38]
Chr11:49055822 [GRCh37]
Chr11:11p11.12		 likely benign
NM_001206626.2(TRIM49B):c.817G>C (p.Gly273Arg) single nucleotide variant not specified [RCV004342343] Chr11:49036356 [GRCh38]
Chr11:49057908 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.414G>A (p.Glu138=) single nucleotide variant not provided [RCV003395788] Chr11:49032278 [GRCh38]
Chr11:49053830 [GRCh37]
Chr11:11p11.12		 likely benign
NM_001206626.2(TRIM49B):c.1104T>A (p.Asn368Lys) single nucleotide variant not specified [RCV004475929] Chr11:49037722 [GRCh38]
Chr11:49059274 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.1030G>C (p.Glu344Gln) single nucleotide variant not specified [RCV004475928] Chr11:49037648 [GRCh38]
Chr11:49059200 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.1114G>T (p.Asp372Tyr) single nucleotide variant not specified [RCV004475930] Chr11:49037732 [GRCh38]
Chr11:49059284 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.702C>G (p.Asn234Lys) single nucleotide variant not specified [RCV004687665] Chr11:49034340 [GRCh38]
Chr11:49055892 [GRCh37]
Chr11:11p11.12		 likely benign
NM_001206626.2(TRIM49B):c.124A>C (p.Asn42His) single nucleotide variant not specified [RCV004475932] Chr11:49031723 [GRCh38]
Chr11:49053275 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.179G>A (p.Gly60Glu) single nucleotide variant not specified [RCV004475933] Chr11:49031778 [GRCh38]
Chr11:49053330 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.302A>G (p.Lys101Arg) single nucleotide variant not specified [RCV004475934] Chr11:49031901 [GRCh38]
Chr11:49053453 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.41T>C (p.Ile14Thr) single nucleotide variant not specified [RCV004475935] Chr11:49031640 [GRCh38]
Chr11:49053192 [GRCh37]
Chr11:11p11.12		 likely benign
NM_001206626.2(TRIM49B):c.493A>G (p.Thr165Ala) single nucleotide variant not specified [RCV004475936] Chr11:49032357 [GRCh38]
Chr11:49053909 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.502T>G (p.Trp168Gly) single nucleotide variant not specified [RCV004475937] Chr11:49032366 [GRCh38]
Chr11:49053918 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.558G>A (p.Met186Ile) single nucleotide variant not specified [RCV004475938] Chr11:49034196 [GRCh38]
Chr11:49055748 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.713A>G (p.His238Arg) single nucleotide variant not specified [RCV004475939] Chr11:49034351 [GRCh38]
Chr11:49055903 [GRCh37]
Chr11:11p11.12		 uncertain significance
NM_001206626.2(TRIM49B):c.833T>C (p.Leu278Pro) single nucleotide variant not specified [RCV004475940] Chr11:49036372 [GRCh38]
Chr11:49057924 [GRCh37]
Chr11:11p11.12		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:157
Count of miRNA genes:155
Interacting mature miRNAs:157
Transcripts:ENST00000332682
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
597121703GWAS1217777_Hserum metabolite measurement QTL GWAS1217777 (human)5e-14serum metabolite measurement114902897149028972Human
597028821GWAS1124895_Hglomerular filtration rate QTL GWAS1124895 (human)3e-10glomerular filtration rateglomerular filtration rate (CMO:0000490)114903605149036052Human
597025644GWAS1121718_Hchronic kidney disease QTL GWAS1121718 (human)0.0000008chronic kidney disease114903605149036052Human
597318022GWAS1414096_Hglomerular filtration rate QTL GWAS1414096 (human)1e-09glomerular filtration rateglomerular filtration rate (CMO:0000490)114903605149036052Human

Markers in Region
RH121076  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371149,048,890 - 49,049,172UniSTSGRCh37
Build 361149,005,466 - 49,005,748RGDNCBI36
Celera1149,200,225 - 49,200,507RGD
Cytogenetic Map11p11.12UniSTS
HuRef1148,766,935 - 48,767,217UniSTS
TNG Radiation Hybrid Map1140726.0UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
22 148 160 167 431 39 87 10 151 8 52 485 405 3 436 47 454 54 2

Sequence


Ensembl Acc Id: ENST00000332682   ⟹   ENSP00000330216
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1149,028,823 - 49,038,155 (+)Ensembl
Ensembl Acc Id: ENST00000622138   ⟹   ENSP00000481457
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1149,027,501 - 49,038,451 (+)Ensembl
RefSeq Acc Id: NM_001206626   ⟹   NP_001193555
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381149,028,823 - 49,038,155 (+)NCBI
GRCh371149,053,152 - 49,059,529 (+)ENTREZGENE
HuRef1148,771,197 - 48,777,572 (+)ENTREZGENE
CHM1_11149,051,586 - 49,057,934 (+)NCBI
T2T-CHM13v2.01149,205,976 - 49,215,304 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001193555 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A6NDI0 (Get FASTA)   NCBI Sequence Viewer  
  AFI99099 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000330216
  ENSP00000330216.7
  ENSP00000481457.1
RefSeq Acc Id: NP_001193555   ⟸   NM_001206626
- UniProtKB: A6NDI0 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000330216   ⟸   ENST00000332682
Ensembl Acc Id: ENSP00000481457   ⟸   ENST00000622138
Protein Domains
B30.2/SPRY

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A6NDI0-F1-model_v2 AlphaFold A6NDI0 1-452 view protein structure

Promoters
RGD ID:7220289
Promoter ID:EPDNEW_H15890
Type:multiple initiation site
Name:TRIM49B_1
Description:tripartite motif containing 49B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381149,028,831 - 49,028,891EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:42955 AgrOrtholog
COSMIC TRIM49B COSMIC
Ensembl Genes ENSG00000182053 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000332682 ENTREZGENE
  ENST00000332682.9 UniProtKB/Swiss-Prot
  ENST00000622138.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.920 UniProtKB/Swiss-Prot
  3.30.40.10 UniProtKB/Swiss-Prot
  Classic Zinc Finger UniProtKB/Swiss-Prot
GTEx ENSG00000182053 GTEx
HGNC ID HGNC:42955 ENTREZGENE
Human Proteome Map TRIM49B Human Proteome Map
InterPro B30.2/SPRY UniProtKB/Swiss-Prot
  B30.2/SPRY_sf UniProtKB/Swiss-Prot
  Butyrophylin_SPRY UniProtKB/Swiss-Prot
  ConA-like_dom_sf UniProtKB/Swiss-Prot
  SPRY_dom UniProtKB/Swiss-Prot
  TRIM/RBCC UniProtKB/Swiss-Prot
  Znf_B-box UniProtKB/Swiss-Prot
  Znf_RING UniProtKB/Swiss-Prot
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot
KEGG Report hsa:283116 UniProtKB/Swiss-Prot
NCBI Gene TRIM49B ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE TRIM UniProtKB/Swiss-Prot
  TRIPARTITE MOTIF-CONTAINING PROTEIN 49B-RELATED UniProtKB/Swiss-Prot
Pfam SPRY UniProtKB/Swiss-Prot
  zf-B_box UniProtKB/Swiss-Prot
  zf-C3HC4_4 UniProtKB/Swiss-Prot
PharmGKB PA166049088 PharmGKB
PRINTS BUTYPHLNCDUF UniProtKB/Swiss-Prot
PROSITE B302_SPRY UniProtKB/Swiss-Prot
  ZF_BBOX UniProtKB/Swiss-Prot
  ZF_RING_2 UniProtKB/Swiss-Prot
SMART BBOX UniProtKB/Swiss-Prot
  RING UniProtKB/Swiss-Prot
  SPRY UniProtKB/Swiss-Prot
Superfamily-SCOP B-box zinc-binding domain UniProtKB/Swiss-Prot
  RING/U-box UniProtKB/Swiss-Prot
  SSF49899 UniProtKB/Swiss-Prot
UniProt A6NDI0 ENTREZGENE, UniProtKB/Swiss-Prot