MIR4787 (microRNA 4787) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: MIR4787 (microRNA 4787) Homo sapiens
Analyze
Symbol: MIR4787
Name: microRNA 4787
RGD ID: 5134197
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-4787
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl350,675,080 - 50,675,163 (+)EnsemblGRCh38hg38GRCh38
GRCh38350,675,080 - 50,675,163 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37350,712,511 - 50,712,594 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map3p21.2NCBI
CHM1_1350,664,704 - 50,664,787 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16381832   PMID:21037258   PMID:21199797   PMID:21558790   PMID:28798470  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:72256
Count of gene targets:22262
Count of transcripts:56978
Interacting mature miRNAs:hsa-miR-4787-3p, hsa-miR-4787-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 7 4 2 5 3 27 8 12 1 18 22
Low 91 52 105 13 62 12 311 75 186 26 161 204 2 17 111
Below cutoff 75 84 65 7 39 3 122 81 212 8 44 51 5 31 81

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000607364
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl350,675,080 - 50,675,163 (+)Ensembl
RefSeq Acc Id: NR_039950
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38350,675,080 - 50,675,163 (+)NCBI
GRCh37350,712,511 - 50,712,594 (+)ENTREZGENE
CHM1_1350,664,704 - 50,664,787 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3p21.31-21.2(chr3:45879883-50749922)x4 copy number gain See cases [RCV000133650] Chr3:45879883..50749922 [GRCh38]
Chr3:45921375..50787353 [GRCh37]
Chr3:45896379..50762357 [NCBI36]
Chr3:3p21.31-21.2
pathogenic
GRCh38/hg38 3p21.31-14.3(chr3:49461000-55314500)x1 copy number loss See cases [RCV000051511] Chr3:49461000..55314500 [GRCh38]
Chr3:49498433..55348528 [GRCh37]
Chr3:49473437..55323568 [NCBI36]
Chr3:3p21.31-14.3
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR4787 COSMIC
Ensembl Genes ENSG00000272543 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000607364 ENTREZGENE
GTEx ENSG00000272543 GTEx
HGNC ID HGNC:41653 ENTREZGENE
Human Proteome Map MIR4787 Human Proteome Map
miRBase MI0017434 ENTREZGENE
NCBI Gene 100616138 ENTREZGENE
RNAcentral URS00002CBC6D RNACentral
  URS0000521832 RNACentral
  URS000075A45B RNACentral