MIR4801 (microRNA 4801) - Rat Genome Database

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Gene: MIR4801 (microRNA 4801) Homo sapiens
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Symbol: MIR4801
Name: microRNA 4801
RGD ID: 5134043
HGNC Page HGNC:41840
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38437,241,910 - 37,241,991 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl437,241,910 - 37,241,991 (-)EnsemblGRCh38hg38GRCh38
GRCh37437,243,532 - 37,243,613 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map4p14NCBI
HuRef436,567,386 - 36,567,467 (-)NCBIHuRef
CHM1_1437,242,648 - 37,242,729 (-)NCBICHM1_1
T2T-CHM13v2.0437,210,245 - 37,210,326 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:21199797  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 4p16.3-14(chr4:72555-39477144)x3 copy number gain See cases [RCV000133677] Chr4:72555..39477144 [GRCh38]
Chr4:72447..39478764 [GRCh37]
Chr4:62447..39155159 [NCBI36]
Chr4:4p16.3-14		 pathogenic
GRCh38/hg38 4p16.3-12(chr4:36424-47491595)x3 copy number gain See cases [RCV000137261] Chr4:36424..47491595 [GRCh38]
Chr4:36424..47493612 [GRCh37]
Chr4:26424..47188369 [NCBI36]
Chr4:4p16.3-12		 pathogenic
GRCh38/hg38 4p16.3-14(chr4:85149-38700366)x3 copy number gain See cases [RCV000051757] Chr4:85149..38700366 [GRCh38]
Chr4:85040..38701987 [GRCh37]
Chr4:75040..38378382 [NCBI36]
Chr4:4p16.3-14		 pathogenic
GRCh38/hg38 4p15.33-14(chr4:11399082-38137335) copy number loss 4p partial monosomy syndrome [RCV003155905] Chr4:11399082..38137335 [GRCh38]
Chr4:4p15.33-14		 pathogenic
GRCh38/hg38 4p16.3-13(chr4:2904667-42963232)x3 copy number gain Neurodevelopmental disorder [RCV003327612] Chr4:2904667..42963232 [GRCh38]
Chr4:4p16.3-13		 pathogenic
GRCh38/hg38 4p16.3-q12(chr4:85624-57073230)x3 copy number gain Neurodevelopmental disorder [RCV003327613] Chr4:85624..57073230 [GRCh38]
Chr4:4p16.3-q12		 pathogenic
GRCh38/hg38 4p16.3-11(chr4:1-49062177)x3 copy number gain Neurodevelopmental disorder [RCV003327611] Chr4:1..49062177 [GRCh38]
Chr4:4p16.3-11		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:13932
Count of gene targets:6015
Count of transcripts:11423
Interacting mature miRNAs:hsa-miR-4801
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
47 11 1 3 59 5 19 10 19 22 56 3 64 5 2 19

Sequence


Ensembl Acc Id: ENST00000582704
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl437,241,910 - 37,241,991 (-)Ensembl
RefSeq Acc Id: NR_039965
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38437,241,910 - 37,241,991 (-)NCBI
GRCh37437,243,532 - 37,243,613 (-)ENTREZGENE
HuRef436,567,386 - 36,567,467 (-)ENTREZGENE
CHM1_1437,242,648 - 37,242,729 (-)NCBI
T2T-CHM13v2.0437,210,245 - 37,210,326 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR4801 COSMIC
Ensembl Genes ENSG00000264319 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000582704 ENTREZGENE
GTEx ENSG00000264319 GTEx
HGNC ID HGNC:41840 ENTREZGENE
Human Proteome Map MIR4801 Human Proteome Map
miRBase MI0017449 ENTREZGENE
NCBI Gene 100616435 ENTREZGENE
RNAcentral URS000020B655 RNACentral
  URS000075CA01 RNACentral