MIR3164 (microRNA 3164) - Rat Genome Database

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Gene: MIR3164 (microRNA 3164) Homo sapiens
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Symbol: MIR3164
Name: microRNA 3164
RGD ID: 4109059
HGNC Page HGNC:38288
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381169,083,176 - 69,083,258 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1169,083,176 - 69,083,258 (+)EnsemblGRCh38hg38GRCh38
GRCh371168,850,644 - 68,850,726 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera1166,190,730 - 66,190,812 (+)NCBICelera
Cytogenetic Map11q13.3NCBI
HuRef1165,189,872 - 65,189,954 (+)NCBIHuRef
CHM1_11168,734,432 - 68,734,514 (+)NCBICHM1_1
T2T-CHM13v2.01169,094,204 - 69,094,286 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:20300190  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q13.2-13.3(chr11:67217264-69448598)x1 copy number loss See cases [RCV000135609] Chr11:67217264..69448598 [GRCh38]
Chr11:66984735..69263366 [GRCh37]
Chr11:66741311..68972547 [NCBI36]
Chr11:11q13.2-13.3		 likely pathogenic
GRCh38/hg38 11q13.2-13.3(chr11:68205963-69580475)x3 copy number gain See cases [RCV000137992] Chr11:68205963..69580475 [GRCh38]
Chr11:67973430..69395243 [GRCh37]
Chr11:67730006..69104424 [NCBI36]
Chr11:11q13.2-13.3		 likely benign
GRCh38/hg38 11q13.2-13.4(chr11:68031693-71593495)x1 copy number loss See cases [RCV000142138] Chr11:68031693..71593495 [GRCh38]
Chr11:67799160..71304541 [GRCh37]
Chr11:67555736..70982189 [NCBI36]
Chr11:11q13.2-13.4		 likely pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:13462
Count of gene targets:6038
Count of transcripts:10880
Interacting mature miRNAs:hsa-miR-3164
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357380BW64_HBody weight QTL 64 (human)2.2Body weightpercent fat after exercise training116097893786978937Human


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
437 1790 1211 1039 1398 602 1009 3 246 663 190 795 3386 2875 49 1058 460 954 647 68

Sequence


Ensembl Acc Id: ENST00000581178
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1169,083,176 - 69,083,258 (+)Ensembl
RefSeq Acc Id: NR_036122
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381169,083,176 - 69,083,258 (+)NCBI
GRCh371168,850,644 - 68,850,726 (+)RGD
Celera1166,190,730 - 66,190,812 (+)RGD
HuRef1165,189,872 - 65,189,954 (+)ENTREZGENE
CHM1_11168,734,432 - 68,734,514 (+)NCBI
T2T-CHM13v2.01169,094,204 - 69,094,286 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR3164 COSMIC
Ensembl Genes ENSG00000265539 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000581178 ENTREZGENE
GTEx ENSG00000265539 GTEx
HGNC ID HGNC:38288 ENTREZGENE
Human Proteome Map MIR3164 Human Proteome Map
miRBase MI0014194 ENTREZGENE
NCBI Gene 100422846 ENTREZGENE
PharmGKB PA165543470 PharmGKB
RNAcentral URS000042E8CC RNACentral
  URS000075E7C6 RNACentral