MIR4262 (microRNA 4262) - Rat Genome Database

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Gene: MIR4262 (microRNA 4262) Homo sapiens
Analyze
Symbol: MIR4262
Name: microRNA 4262
RGD ID: 4108923
HGNC Page HGNC:38308
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38211,836,933 - 11,836,986 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl211,836,933 - 11,836,986 (-)EnsemblGRCh38hg38GRCh38
GRCh37211,977,059 - 11,977,112 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera211,894,198 - 11,894,251 (-)NCBICelera
Cytogenetic Map2p25.1NCBI
HuRef211,828,381 - 11,828,434 (-)NCBIHuRef
CHM1_1211,906,601 - 11,906,654 (-)NCBICHM1_1
T2T-CHM13v2.0211,870,050 - 11,870,103 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
schizophrenia  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Schizophrenia  (IAGP)
References
Additional References at PubMed
PMID:16381832   PMID:19784364   PMID:26634745   PMID:26778158   PMID:27629257   PMID:27779691   PMID:28731150   PMID:28800784   PMID:31184231   PMID:31831299   PMID:32473153   PMID:33070767  
PMID:35220889  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2p25.3-23.2(chr2:30341-28419664)x3 copy number gain See cases [RCV000135398] Chr2:30341..28419664 [GRCh38]
Chr2:30341..28642531 [GRCh37]
Chr2:20341..28496035 [NCBI36]
Chr2:2p25.3-23.2		 pathogenic
GRCh38/hg38 2p25.3-23.3(chr2:17019-26318846)x3 copy number gain See cases [RCV000137344] Chr2:17019..26318846 [GRCh38]
Chr2:17019..26541714 [GRCh37]
Chr2:7019..26395218 [NCBI36]
Chr2:2p25.3-23.3		 pathogenic
GRCh38/hg38 2p25.3-24.1(chr2:1664615-23664142)x3 copy number gain See cases [RCV000137913] Chr2:1664615..23664142 [GRCh38]
Chr2:1668387..23887012 [GRCh37]
Chr2:1647394..23740517 [NCBI36]
Chr2:2p25.3-24.1		 pathogenic|likely pathogenic
GRCh38/hg38 2p25.3-24.1(chr2:17019-20001056)x3 copy number gain See cases [RCV000141226] Chr2:17019..20001056 [GRCh38]
Chr2:17019..20200817 [GRCh37]
Chr2:7019..20064298 [NCBI36]
Chr2:2p25.3-24.1		 pathogenic
GRCh38/hg38 2p25.3-23.3(chr2:12770-25039694)x3 copy number gain See cases [RCV000141877] Chr2:12770..25039694 [GRCh38]
Chr2:12770..25262563 [GRCh37]
Chr2:2770..25116067 [NCBI36]
Chr2:2p25.3-23.3		 pathogenic
GRCh38/hg38 2p25.1(chr2:11270488-11924312)x3 copy number gain See cases [RCV000141963] Chr2:11270488..11924312 [GRCh38]
Chr2:11410614..12064438 [GRCh37]
Chr2:11328065..11981889 [NCBI36]
Chr2:2p25.1		 uncertain significance
GRCh38/hg38 2p25.3-22.3(chr2:12770-33711509)x3 copy number gain See cases [RCV000141829] Chr2:12770..33711509 [GRCh38]
Chr2:12770..33936576 [GRCh37]
Chr2:2770..33790080 [NCBI36]
Chr2:2p25.3-22.3		 pathogenic
GRCh38/hg38 2p25.1-11.2(chr2:7495123-87705899)x3 copy number gain See cases [RCV000141494] Chr2:7495123..87705899 [GRCh38]
Chr2:7635254..88005418 [GRCh37]
Chr2:7552705..87786533 [NCBI36]
Chr2:2p25.1-11.2		 benign
GRCh38/hg38 2p25.1-24.3(chr2:10790663-14417134)x3 copy number gain See cases [RCV000142512] Chr2:10790663..14417134 [GRCh38]
Chr2:10930789..14557258 [GRCh37]
Chr2:10848240..14474709 [NCBI36]
Chr2:2p25.1-24.3		 pathogenic
GRCh38/hg38 2p25.3-21(chr2:236816-45983232)x3 copy number gain See cases [RCV000143682] Chr2:236816..45983232 [GRCh38]
Chr2:236816..46210371 [GRCh37]
Chr2:226816..46063875 [NCBI36]
Chr2:2p25.3-21		 pathogenic
GRCh38/hg38 2p25.3-24.3(chr2:30141-14494040)x3 copy number gain See cases [RCV000052928] Chr2:30141..14494040 [GRCh38]
Chr2:30141..14634164 [GRCh37]
Chr2:20141..14551615 [NCBI36]
Chr2:2p25.3-24.3		 pathogenic
GRCh38/hg38 2p25.3-23.1(chr2:30141-31766749)x3 copy number gain See cases [RCV000052929] Chr2:30141..31766749 [GRCh38]
Chr2:30141..31991818 [GRCh37]
Chr2:20141..31845322 [NCBI36]
Chr2:2p25.3-23.1		 pathogenic
GRCh38/hg38 2p25.3-24.3(chr2:30342-14866951)x3 copy number gain See cases [RCV000052931] Chr2:30342..14866951 [GRCh38]
Chr2:30342..15007075 [GRCh37]
Chr2:20342..14924526 [NCBI36]
Chr2:2p25.3-24.3		 pathogenic
GRCh38/hg38 2p25.3-16.1(chr2:66097-55570637)x3 copy number gain See cases [RCV000052933] Chr2:66097..55570637 [GRCh38]
Chr2:66097..55797773 [GRCh37]
Chr2:56097..55651277 [NCBI36]
Chr2:2p25.3-16.1		 pathogenic
GRCh38/hg38 2p25.1-24.3(chr2:10216779-13474790)x3 copy number gain See cases [RCV000052627] Chr2:10216779..13474790 [GRCh38]
Chr2:10356905..13614915 [GRCh37]
Chr2:10274356..13532366 [NCBI36]
Chr2:2p25.1-24.3		 uncertain significance
GRCh38/hg38 2p25.2-24.3(chr2:6531172-16103799)x1 copy number loss See cases [RCV000053978] Chr2:6531172..16103799 [GRCh38]
Chr2:6671304..16243921 [GRCh37]
Chr2:6588755..16161372 [NCBI36]
Chr2:2p25.2-24.3		 pathogenic
NC_000002.12:g.(?_11177745)_(16113827_?)del deletion Schizophrenia [RCV000754225] Chr2:11177745..16113827 [GRCh38]
Chr2:2p25.1-24.3		 likely pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:13212
Count of gene targets:5601
Count of transcripts:10539
Interacting mature miRNAs:hsa-miR-4262
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1 4 1 4 16 4 14 4 99 3 8 102 96 3 9 2 9 11 1

Sequence


Ensembl Acc Id: ENST00000578394
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl211,836,933 - 11,836,986 (-)Ensembl
RefSeq Acc Id: NR_036226
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38211,836,933 - 11,836,986 (-)NCBI
GRCh37211,977,059 - 11,977,112 (-)RGD
Celera211,894,198 - 11,894,251 (-)RGD
HuRef211,828,381 - 11,828,434 (-)RGD
CHM1_1211,906,601 - 11,906,654 (-)NCBI
T2T-CHM13v2.0211,870,050 - 11,870,103 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR4262 COSMIC
Ensembl Genes ENSG00000265172 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000578394 ENTREZGENE
GTEx ENSG00000265172 GTEx
HGNC ID HGNC:38308 ENTREZGENE
Human Proteome Map MIR4262 Human Proteome Map
miRBase MI0015872 ENTREZGENE
NCBI Gene 100422996 ENTREZGENE
PharmGKB PA165696818 PharmGKB
RNAcentral URS0000759A3D RNACentral
  URS000075BACE RNACentral