MIR1260B (microRNA 1260b) - Rat Genome Database

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Gene: MIR1260B (microRNA 1260b) Homo sapiens
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Symbol: MIR1260B
Name: microRNA 1260b
RGD ID: 4108921
HGNC Page HGNC:38258
Description: Enables mRNA base-pairing translational repressor activity. Involved in miRNA-mediated post-transcriptional gene silencing and positive regulation of canonical Wnt signaling pathway.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-1260b
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381196,341,438 - 96,341,526 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1196,341,438 - 96,341,526 (+)EnsemblGRCh38hg38GRCh38
GRCh371196,074,602 - 96,074,690 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera1193,374,805 - 93,374,893 (+)NCBICelera
Cytogenetic Map11q21NCBI
HuRef1192,141,322 - 92,141,410 (+)NCBIHuRef
CHM1_11195,957,959 - 95,958,047 (+)NCBICHM1_1
T2T-CHM13v2.01196,347,441 - 96,347,529 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References
Additional References at PubMed
PMID:16381832   PMID:20300190   PMID:21037258   PMID:23591200   PMID:24504368   PMID:27399918   PMID:27573701   PMID:29038925   PMID:30737371   PMID:31818357   PMID:32026462   PMID:34321461  
PMID:35165858   PMID:35325509   PMID:36056852  


Genomics

Variants

.
Variants in MIR1260B
2 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q13.5-22.1(chr11:75941754-98357960)x1 copy number loss See cases [RCV000133838] Chr11:75941754..98357960 [GRCh38]
Chr11:75652798..98228688 [GRCh37]
Chr11:75330446..97733898 [NCBI36]
Chr11:11q13.5-22.1		 pathogenic
GRCh38/hg38 11q14.3-22.3(chr11:91086659-109595582)x1 copy number loss See cases [RCV000138038] Chr11:91086659..109595582 [GRCh38]
Chr11:90819827..109466308 [GRCh37]
Chr11:90459475..108971518 [NCBI36]
Chr11:11q14.3-22.3		 pathogenic
GRCh38/hg38 11q14.1-22.3(chr11:78232836-106779420)x1 copy number loss See cases [RCV000052710] Chr11:78232836..106779420 [GRCh38]
Chr11:77943882..106650146 [GRCh37]
Chr11:77621530..106155356 [NCBI36]
Chr11:11q14.1-22.3		 pathogenic
GRCh38/hg38 11q14.1-22.2(chr11:85242847-102920097)x1 copy number loss See cases [RCV000052711] Chr11:85242847..102920097 [GRCh38]
Chr11:84953891..102738968 [GRCh37]
Chr11:84631539..102296037 [NCBI36]
Chr11:11q14.1-22.2		 pathogenic
NM_032427.4(MAML2):c.457G>A (p.Glu153Lys) single nucleotide variant not specified [RCV004155197] Chr11:96341439 [GRCh38]
Chr11:96074603 [GRCh37]
Chr11:11q21		 uncertain significance
NM_032427.4(MAML2):c.410A>G (p.His137Arg) single nucleotide variant not specified [RCV004198103] Chr11:96341486 [GRCh38]
Chr11:96074650 [GRCh37]
Chr11:11q21		 uncertain significance
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
TMEM167Ahsa-miR-1260bMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248

Predicted Targets
Summary Value
Count of predictions:24871
Count of gene targets:10967
Count of transcripts:22206
Interacting mature miRNAs:hsa-miR-1260b
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
33 51 14 46 2 4 55 8 25 112 63 23 39 22 32 36

Sequence


Ensembl Acc Id: ENST00000582890
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1196,341,438 - 96,341,526 (+)Ensembl
RefSeq Acc Id: NR_036125
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381196,341,438 - 96,341,526 (+)NCBI
GRCh371196,074,602 - 96,074,690 (+)RGD
Celera1193,374,805 - 93,374,893 (+)RGD
HuRef1192,141,322 - 92,141,410 (+)ENTREZGENE
CHM1_11195,957,959 - 95,958,047 (+)NCBI
T2T-CHM13v2.01196,347,441 - 96,347,529 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR1260B COSMIC
Ensembl Genes ENSG00000266192 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000582890 ENTREZGENE
GTEx ENSG00000266192 GTEx
HGNC ID HGNC:38258 ENTREZGENE
Human Proteome Map MIR1260B Human Proteome Map
miRBase MI0014197 ENTREZGENE
NCBI Gene 100422991 ENTREZGENE
OMIM 615372 OMIM
PharmGKB PA165543463 PharmGKB
RNAcentral URS0000239117 RNACentral
  URS0000759BF7 RNACentral