LOC114515513 (olfactory receptor enhancer Rhodes) - Rat Genome Database

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Gene: LOC114515513 (olfactory receptor enhancer Rhodes) Mus musculus
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Symbol: LOC114515513
Name: olfactory receptor enhancer Rhodes
RGD ID: 39130376
Description: This genomic region represents one of several intergenic enhancers, known as Greek islands, which aggregate to form an interchromosomal hub that enables expression of a single olfactory receptor (OR) gene in olfactory sensory neurons. While all of the other OR gene clusters are sequestered in a large heterochromatic domain, this multi-enhancer interaction network evades heterochromatic silencing by associating with the transcription factors Lhx2 (LIM homeobox 2) and Ebf (EBF transcription factor), which bind in a functionally cooperative manner to allow expression of the active OR gene. The Greek island represented in this genomic region, Rhodes, was validated as a functional enhancer by reporter assays in olfactory sensory neurons of transgenic zebrafish embryos. Additionally, upregulation of the nearby OR gene cluster (Or6b2, Or6b2b, Or6b3, Or9s13, Or9s14, Or9s15, Or9s23 and Or9s27) was observed in olfactory epithelium when an array, which included this enhancer along with the Lipsi, Sfaktiria, Crete and H Greek islands, was inserted next to the endogenous Rhodes enhancer. [provided by RefSeq, Apr 2023]
Type: biological-region
RefSeq Status: REVIEWED
Previously known as: Rr366820
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39192,472,653 - 92,474,462 (+)NCBIGRCm39GRCm39mm39
GRCm38192,544,931 - 92,546,740 (+)NCBIGRCm38GRCm38mm10GRCm38
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:23240088   PMID:25417106   PMID:26359778   PMID:28933695   PMID:30626972   PMID:30666054  


Genomics


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
15039333Nmrs1_mNAFLD-associated magnetic resonance shift 1 (mouse)189786512123786512Mouse
1357847Jckm2_mjuvenile cystic kidney modifier 2 (mouse)Not determined174991977133290937Mouse
4142394Mssq1_mmandible size and shape QTL 1 (mouse)Not determined73615692107615830Mouse
1300821Lore1_mloss of righting induced by ethanol 1 (mouse)Not determined17554919192941077Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1558928Mord2_mmodifier of retinal degeneration 2 (mouse)Not determined177123115110536075Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
14697706Stsl3a_mSalmonella typhimurium susceptibility locus 3a (mouse)17747663795827725Mouse
12790991Aath1_maortic arch atherosclerosis 1 (mouse)186483929120483929Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
10412238Alpq5_malcohol preference QTL 5 (mouse)Not determined182832635116832635Mouse
1302146Cocrb1_mcocaine related behavior 1 (mouse)Not determined170133533104139557Mouse
1301444Alcw5_malcohol withdrawal 5 (mouse)Not determined15854919192549443Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
4141347Reb1_mrepetitive behavior 1 (mouse)Not determined91468266100413667Mouse
12791004Aath7_maortic arch atherosclerosis 7 (mouse)182832635116832635Mouse
4141725Wbcq4_mwhite blood cell quantitative locus 4 (mouse)Not determined179858683113858791Mouse
12050069Nabq1_mnasal bone morphology QTL 1 (mouse)179858683113858791Mouse
1300976Bmd19_mbone mineral density 19 (mouse)Not determined173266214108838414Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74516235148715579Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)175976637148775742Mouse
27095931Pglq1_mpelvic girdle length QTL 1, 5 week (mouse)175976637128527737Mouse
13452395Leusq2_mleucocytosis susceptibility QTL 2 (mouse)180245593126386517Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162946755120529678Mouse
1301304Hrq3_mheart rate quantitative locus 3 (mouse)Not determined173615692107615830Mouse
1357439Popoa_mpremature ovulation and primary oocyte arrest (mouse)Not determined182643189135615379Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
4141329Mleu1_mmyeloid leukemia survival 1 (mouse)Not determined89786512123786512Mouse
1301667Lxw5_mlupus BXSB x NZW 5 (mouse)Not determined15854919192549443Mouse
11667074Led2_mlate embryonic death 2 (mouse)185696027117195081Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167339159129727737Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782291982147125370Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NG_064613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC102923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles


Additional Information

Database Acc Id Source(s)
NCBI Gene LOC114515513 ENTREZGENE
PhenoGen LOC114515513 PhenoGen