LOC114515513 (olfactory receptor enhancer Rhodes) - Rat Genome Database

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Gene: LOC114515513 (olfactory receptor enhancer Rhodes) Mus musculus
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Symbol: LOC114515513
Name: olfactory receptor enhancer Rhodes
RGD ID: 39130376
Description: This genomic region represents one of several intergenic enhancers, known as Greek islands, which aggregate to form an interchromosomal hub that enables expression of a single olfactory receptor (OR) gene in olfactory sensory neurons. While all of the other OR gene clusters are sequestered in a large heterochromatic domain, this multi-enhancer interaction network evades heterochromatic silencing by associating with the transcription factors Lhx2 (LIM homeobox 2) and Ebf (EBF transcription factor), which bind in a functionally cooperative manner to allow expression of the active OR gene. The Greek island represented in this genomic region, Rhodes, was validated as a functional enhancer by reporter assays in olfactory sensory neurons of transgenic zebrafish embryos. Additionally, upregulation of the nearby OR gene cluster (Or6b2, Or6b2b, Or6b3, Or9s13, Or9s14, Or9s15, Or9s23 and Or9s27) was observed in olfactory epithelium when an array, which included this enhancer along with the Lipsi, Sfaktiria, Crete and H Greek islands, was inserted next to the endogenous Rhodes enhancer. [provided by RefSeq, Apr 2023]
Type: biological-region
RefSeq Status: REVIEWED
Previously known as: Rr366820
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39192,472,653 - 92,474,462 (+)NCBIGRCm39GRCm39mm39
GRCm38192,544,931 - 92,546,740 (+)NCBIGRCm38GRCm38mm10GRCm38
JBrowse: View Region in Genome Browser (JBrowse)
Model


PMID:23240088   PMID:25417106   PMID:26359778   PMID:28933695   PMID:30626972   PMID:30666054  



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Variants in LOC114515513
92 total Variants

1 to 10 of 39 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
15039333Nmrs1_mNAFLD-associated magnetic resonance shift 1 (mouse)189786512123786512Mouse
1357847Jckm2_mjuvenile cystic kidney modifier 2 (mouse)Not determined174991977133290937Mouse
4142394Mssq1_mmandible size and shape QTL 1 (mouse)Not determined73615692107615830Mouse
1300821Lore1_mloss of righting induced by ethanol 1 (mouse)Not determined17554919192941077Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1558928Mord2_mmodifier of retinal degeneration 2 (mouse)Not determined177123115110536075Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
14697706Stsl3a_mSalmonella typhimurium susceptibility locus 3a (mouse)17747663795827725Mouse

1 to 10 of 39 rows





RefSeq Transcripts NG_064613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC102923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles



Database
Acc Id
Source(s)
NCBI Gene LOC114515513 ENTREZGENE
PhenoGen LOC114515513 PhenoGen