This genomic region encompasses several DNase I hypersensitive sites and includes an enhancer of paired box 5 (Pax5) in B cells. Activity of this enhancer may be regulated by binding by Spi-1 proto-oncogene, nuclear factor kappa B, and interferon regulatory factors. This locus also includes two B cell regulatory elements that were identified by FAIRE-seq (formaldehyde-assisted isolation of regulatory elements sequencing), and which were validated as enhancers by STARR-seq (self-transcribing active regulatory region sequencing) in lipopolysaccharide-activated mouse splenic B cells. [provided by RefSeq, Oct 2023]