Defb9 (defensin beta 9) - Rat Genome Database

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Gene: Defb9 (defensin beta 9) Mus musculus
Analyze
No known orthologs.
Symbol: Defb9
Name: defensin beta 9
RGD ID: 1621282
MGI Page MGI
Description: Predicted to enable CCR6 chemokine receptor binding activity. Predicted to be involved in defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; and innate immune response in mucosa. Predicted to be located in extracellular region. Predicted to be active in extracellular space.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BD-9; beta-defensin 9; defensin, beta 9; mBD-9; MGC129393
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39822,371,729 - 22,375,458 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl822,371,729 - 22,375,437 (-)EnsemblGRCm39 Ensembl
GRCm38821,881,713 - 21,885,434 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl821,881,713 - 21,885,421 (-)EnsemblGRCm38mm10GRCm38
MGSCv37822,992,185 - 22,995,906 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36823,347,281 - 23,350,966 (-)NCBIMGSCv36mm8
Celera823,371,695 - 23,375,340 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map810.54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:12466851   PMID:12477932   PMID:12644567   PMID:16602821   PMID:20003482   PMID:21873635  


Genomics

Variants

.
Variants in Defb9
111 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:61
Interacting mature miRNAs:61
Transcripts:ENSMUST00000057076
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357525Pnhdlc3_mplasma non-HDL cholesterol 3 (mouse)Not determined8721249923753815Mouse
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
1301298Pgia4_mproteoglycan induced arthritis 4 (mouse)Not determined81656937350569697Mouse
1300912Daq19_mdirectional asymmetry QTL 19 (mouse)Not determined81550657249506729Mouse
11532713Sluc42_msusceptibility to lung cancer 42 (mouse)81344721035321225Mouse
4142199Poats1_mpost-ovarectomy adrenal tumor susceptibility 1 (mouse)Not determined1708262628849467Mouse
1300603Cd8ts2_mCD8 T cell subset 2 (mouse)Not determined81945501853455150Mouse
4140978Nilac5_mnicotine induced locomotor activity 5 (mouse)Not determined8131773288Mouse
1301532Scc8_mcolon tumor susceptibility 8 (mouse)Not determined8721249935110107Mouse
10412209Cypr7_mcytokine production 7 (mouse)Not determined8810320142103372Mouse
1301088Alcw6_malcohol withdrawal 6 (mouse)Not determined81550657249506729Mouse
11533914Mts5_mmammary tumor susceptibility 5 (mouse)8130447432Mouse
13432571Scvg1_msubcutaneous vessel growth QTL 1 (mouse)8124751082Mouse
1300906Ap8q_malcohol preference 8 QTL (mouse)Not determined8798418941984342Mouse
1301929Eae24_msusceptibility to experimental allergic encephalomyelitis 24 (mouse)Not determined8810320142103372Mouse
27226756Femd2_mfemur midshaft diameter 2, 5 week (mouse)8495000035067154Mouse
1301128Sluc20_msusceptibility to lung cancer 20 (mouse)Not determined8810320142103372Mouse
1301160Eae14_msusceptibility to experimental allergic encephalomyelitis 14 (mouse)Not determined81945501853455150Mouse
1301550Fembrs2_mfemur breaking strength 2 (mouse)Not determined81832109752321225Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000057076   ⟹   ENSMUSP00000054085
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl822,371,729 - 22,375,437 (-)Ensembl
GRCm38.p6 Ensembl821,881,713 - 21,885,421 (-)Ensembl
RefSeq Acc Id: NM_139219   ⟹   NP_631965
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39822,371,729 - 22,375,458 (-)NCBI
GRCm38821,881,713 - 21,885,434 (-)ENTREZGENE
MGSCv37822,992,185 - 22,995,906 (-)RGD
Celera823,371,695 - 23,375,340 (-)RGD
cM Map8 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_631965 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI09178 (Get FASTA)   NCBI Sequence Viewer  
  CAD26896 (Get FASTA)   NCBI Sequence Viewer  
  EDL32919 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000054085
  ENSMUSP00000054085.5
GenBank Protein Q8R2I6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_631965   ⟸   NM_139219
- Peptide Label: precursor
- UniProtKB: Q8R2I6 (UniProtKB/Swiss-Prot),   Q32MD8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000054085   ⟸   ENSMUST00000057076

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R2I6-F1-model_v2 AlphaFold Q8R2I6 1-67 view protein structure

Promoters
RGD ID:8666639
Promoter ID:EPDNEW_M11350
Type:single initiation site
Name:Defb9_1
Description:Mus musculus defensin beta 9 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38821,885,442 - 21,885,502EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2179198 AgrOrtholog
Ensembl Genes ENSMUSG00000047390 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000057076 ENTREZGENE
  ENSMUST00000057076.5 UniProtKB/Swiss-Prot
InterPro Defensin_beta-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:246079 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2179198 ENTREZGENE
NCBI Gene 246079 ENTREZGENE
PANTHER BETA-DEFENSIN 10-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BETA-DEFENSIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Defensin_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Defb9 PhenoGen
Superfamily-SCOP Defensin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt DEFB9_MOUSE UniProtKB/Swiss-Prot
  Q32MD8 ENTREZGENE, UniProtKB/TrEMBL
  Q8R2I6 ENTREZGENE