Zfp456 (zinc finger protein 456) - Rat Genome Database

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Gene: Zfp456 (zinc finger protein 456) Mus musculus
Analyze
No known orthologs.
Symbol: Zfp456
Name: zinc finger protein 456
RGD ID: 1614741
MGI Page MGI
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF429 (zinc finger protein 429).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BC065418; MGC73892; Rslc; Rslcan-13
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391367,511,700 - 67,523,872 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1367,493,310 - 67,523,852 (-)EnsemblGRCm39 Ensembl
GRCm39 Ensembl1367,510,232 - 67,523,929 (-)EnsemblGRCm39 Ensembl
GRCm381367,363,584 - 67,375,763 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1367,345,246 - 67,375,733 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl1367,362,113 - 67,375,810 (-)EnsemblGRCm38mm10GRCm38
MGSCv371367,464,520 - 67,476,699 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361367,862,681 - 67,874,863 (-)NCBIMGSCv36mm8
Celera1369,932,546 - 69,944,689 (+)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1334.54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA)

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14563677   PMID:16141072   PMID:16141073   PMID:21873635  


Genomics

Variants

.
Variants in Zfp456
408 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:725
Count of miRNA genes:486
Interacting mature miRNAs:561
Transcripts:ENSMUST00000057070, ENSMUST00000166080, ENSMUST00000172266
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300561Heal7_mwound healing/regeneration 7 (mouse)Not determined133614482070144904Mouse
4142331Bxs6_mBXSB/MpJ autoimmune nephritis 6 (mouse)Not determined4521044283744746Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
1357587Pfat3_mpredicted fat percentage 3 (mouse)Not determined133610153070101640Mouse
1300573Elsgp2_melevated serum gp70 2 (mouse)Not determined135061682884617027Mouse
10412109Bxs7_mBXSB/MpJ autoimmune nephritis 7 (mouse)Not determined134521044283744746Mouse
10412235Scgq5_mspontaneous crescentic glomerulonephritis QTL 5 (mouse)Not determined133606090896239162Mouse
4142314Tailaq3_mtail length adjusted QTL 3 (mouse)Not determined55720354112431103Mouse
1558850Sgp3_mserum gp70 production 3 (mouse)Not determined135647045676971314Mouse
1301445Listr2_mlisteriosis resistance 2 (mouse)Not determined1366744601100744746Mouse
4141992W6q16_mweight 6 weeks QTL 16 (mouse)Not determined55720354112431103Mouse
4142372Moo2_mmodifier of Odc2 (mouse)Not determinedX5031841184318559Mouse
15039353Nmrs35_mNAFLD-associated magnetic resonance shift 35 (mouse)134058825374588253Mouse
10412163Wra1_mwheel running activity 1 (mouse)Not determined135913260093132738Mouse
1302157Bwem2_mbody weight day 30 males 2 (mouse)Not determined133962924973629397Mouse
4142241Tailq3_mtail length QTL 3 (mouse)Not determined55720354112431103Mouse
1300941Skl6_mskeletal size (tail length) 6 (mouse)Not determined136425082198250945Mouse
1301299Sluc23_msusceptibility to lung cancer 23 (mouse)Not determined133492194368922081Mouse
4140959W10q17_mweight 10 weeks QTL 17 (mouse)Not determined55720354112431103Mouse
1357553Cia28_mcollagen induced arthritis 28 (mouse)Not determined135662924996239162Mouse
1300985Bmd13_mbone mineral density 13 (mouse)Not determined133962924973629397Mouse
1302073Pgct1_mprimordial germ cell tumor locus 1 (mouse)Not determined135382078387820897Mouse
1300862Cfbw5_mcystic fibrosis body weight 5 (mouse)Not determined133872035872720517Mouse
1301949Skull20_mskull morphology 20 (mouse)Not determined136425082198250945Mouse
1300668Pas10_mpulmonary adenoma susceptibility 10 (mouse)Not determined134148904275489158Mouse
1357563Bmch6_mbone mechanical trait 6 (mouse)Not determined135538498089385140Mouse
10402414Sgp5_mserum gp70 production 5 (mouse)Not determined1356470456105422186Mouse
1301666Eae13_msusceptibility to experimental allergic encephalomyelitis 13 (mouse)Not determined135031841184318559Mouse
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1301734Acsns2_mAngiostrongylus costaricensis nematode susceptibility 2 (mouse)Not determined133610153070101640Mouse
26884396Humsd4_mhumerus midshaft diameter 4, 10 week (mouse)134785347673148119Mouse
1301801Cpfd5_mcerebellum pattern fissures (mouse)Not determined133962924973629397Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
14746975Manh74_mmandible shape 74 (mouse)135247726986477269Mouse

Markers in Region
D1S3257  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381367,358,488 - 67,358,853UniSTSGRCm38
MGSCv371367,459,424 - 67,459,789UniSTSGRCm37
Cytogenetic Map13B3UniSTS
cM Map1340.9UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000057070   ⟹   ENSMUSP00000059686
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1367,511,703 - 67,523,929 (-)Ensembl
GRCm38.p6 Ensembl1367,363,584 - 67,375,810 (-)Ensembl
Ensembl Acc Id: ENSMUST00000166080   ⟹   ENSMUSP00000126669
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1367,493,310 - 67,523,852 (-)Ensembl
GRCm38.p6 Ensembl1367,345,246 - 67,375,733 (-)Ensembl
Ensembl Acc Id: ENSMUST00000172266   ⟹   ENSMUSP00000130928
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1367,510,232 - 67,523,929 (-)Ensembl
GRCm38.p6 Ensembl1367,362,113 - 67,375,810 (-)Ensembl
Ensembl Acc Id: ENSMUST00000225787   ⟹   ENSMUSP00000153162
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1367,520,361 - 67,523,832 (-)Ensembl
GRCm38.p6 Ensembl1367,372,242 - 67,375,713 (-)Ensembl
RefSeq Acc Id: NM_001001186   ⟹   NP_001001186
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391367,511,700 - 67,523,872 (-)NCBI
GRCm381367,363,584 - 67,375,763 (-)ENTREZGENE
MGSCv371367,464,520 - 67,476,699 (-)RGD
Celera1369,932,546 - 69,944,689 (+)RGD
cM Map13 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001001186 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI41198 (Get FASTA)   NCBI Sequence Viewer  
  DAA01850 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000059686
  ENSMUSP00000059686.9
  ENSMUSP00000126669.2
  ENSMUSP00000130928.2
  ENSMUSP00000153162.2
RefSeq Acc Id: NP_001001186   ⟸   NM_001001186
- UniProtKB: B2RUK9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000130928   ⟸   ENSMUST00000172266
Ensembl Acc Id: ENSMUSP00000126669   ⟸   ENSMUST00000166080
Ensembl Acc Id: ENSMUSP00000153162   ⟸   ENSMUST00000225787
Ensembl Acc Id: ENSMUSP00000059686   ⟸   ENSMUST00000057070
Protein Domains
C2H2-type   KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RUK9-F1-model_v2 AlphaFold B2RUK9 1-458 view protein structure

Promoters
RGD ID:8680710
Promoter ID:EPDNEW_M18385
Type:initiation region
Name:Zfp456_1
Description:Mus musculus zinc finger protein 456 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381367,375,753 - 67,375,813EPDNEW
RGD ID:6824511
Promoter ID:MM_KWN:14563
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   MEF_B6
Transcripts:NM_001001186
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361367,476,496 - 67,476,996 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3040694 AgrOrtholog
Ensembl Genes ENSMUSG00000078995 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSG00000098692 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000057070 ENTREZGENE
  ENSMUST00000057070.9 UniProtKB/TrEMBL
  ENSMUST00000166080.2 UniProtKB/TrEMBL
  ENSMUST00000172266.8 UniProtKB/TrEMBL
  ENSMUST00000225787.2 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel-associated_box UniProtKB/TrEMBL
  Krueppel_C2H2_ZnF UniProtKB/TrEMBL
  Krueppel_C2H2_ZnFinger UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report mmu:408065 UniProtKB/TrEMBL
MGD MGI:3040694 ENTREZGENE
NCBI Gene 408065 ENTREZGENE
PANTHER IP01015P-RELATED UniProtKB/TrEMBL
  KRAB DOMAIN C2H2 ZINC FINGER UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 589 UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 91 UniProtKB/TrEMBL
  ZINC FINGER PROTEIN HOMOLOG UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zfp456 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP Krueppel-associated_box UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A286YCV7_MOUSE UniProtKB/TrEMBL
  B2RUK9 ENTREZGENE, UniProtKB/TrEMBL
  F2Z406_MOUSE UniProtKB/TrEMBL
  Q7M6X8_MOUSE UniProtKB/TrEMBL