Defa10 (defensin, alpha, 10) - Rat Genome Database

Name: Defa10
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Advanced Search (OLGA)

Gene: Defa10 (defensin, alpha, 10) Mus musculus

Analyze

No known orthologs.

Symbol:

Defa10

Name:

defensin, alpha, 10

RGD ID:

1612770

MGI Page

MGI

Description:

Predicted to enable pore-forming activity and protein homodimerization activity. Predicted to be involved in cellular response to lipopolysaccharide; defense response to other organism; and disruption of plasma membrane integrity in another organism. Predicted to be located in midbody and secretory granule. Predicted to be active in extracellular space. Orthologous to several human genes including DEFA1 (defensin alpha 1); DEFA1B (defensin alpha 1B); and DEFA5 (defensin alpha 5).

Type:

protein-coding

Previously known as:

alpha-defensin 10; alpha-defensin, 10; Defcr1; Defcr10; defensin related cryptdin 10; defensin-related cryptdin-10

RGD Orthologs

Alliance Orthologs

More Info

homologs ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Other homologs ²				less info ...
Homo sapiens (human):	DEFA6 (defensin alpha 6)	HGNC	Panther
Homo sapiens (human):	DEFA3 (defensin alpha 3)	HGNC	Panther
Homo sapiens (human):	DEFA5 (defensin alpha 5)	HGNC	Panther
Homo sapiens (human):	DEFA1 (defensin alpha 1)	HGNC	Panther
Homo sapiens (human):	DEFA4 (defensin alpha 4)	HGNC	Panther
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Defa24 (defensin alpha 24)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Homo sapiens (human):	DEFA6 (defensin alpha 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoInspector\|PANTHER)
Homo sapiens (human):	DEFA3 (defensin alpha 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoInspector\|PANTHER)
Homo sapiens (human):	DEFA5 (defensin alpha 5)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|PANTHER)
Homo sapiens (human):	DEFA1 (defensin alpha 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoInspector\|PANTHER)
Homo sapiens (human):	DEFA1B (defensin alpha 1B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoInspector\|PANTHER)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

NCBI Annotation Information:

Genome Annotation Status: not in current annotation release

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Cytogenetic Map	8		NCBI

Annotation Click to see Annotation Detail View

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antibacterial humoral response (IBA)

antimicrobial humoral immune response mediated by antimicrobial peptide (IBA)

cellular response to lipopolysaccharide (IBA)

defense response to bacterium (IEA)

defense response to Gram-negative bacterium (IBA)

defense response to Gram-positive bacterium (IBA)

disruption of plasma membrane integrity in another organism (IBA)

innate immune response in mucosa (IBA)

Cellular Component

extracellular space (IBA,IEA,ISO)

intracellular membrane-bounded organelle (ISO)

midbody (ISO)

secretory granule (ISO)

Molecular Function

pore-forming activity (ISO)

protein homodimerization activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:7927786	PMID:8188287	PMID:20003482	PMID:21873635

Genomics

Markers in Region

Defcr3

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	8	A2	UniSTS
cM Map	8		UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


GenBank Nucleotide	U03061	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Protein Sequences


GenBank Protein	AAA57178	(Get FASTA)	NCBI Sequence Viewer
	P50708	(Get FASTA)	NCBI Sequence Viewer

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P50708-F1-model_v2	AlphaFold	P50708	1-93	view protein structure

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:99591	AgrOrtholog
InterPro	Alpha-defensin	UniProtKB/Swiss-Prot
	Alpha-defensin_pro	UniProtKB/Swiss-Prot
	Defensin_beta/alpha	UniProtKB/Swiss-Prot
	Defensin_propep	UniProtKB/Swiss-Prot
MGD	MGI:99591	ENTREZGENE
NCBI Gene	13229	ENTREZGENE
PANTHER	ALPHA-DEFENSIN 1-RELATED	UniProtKB/Swiss-Prot
	PTHR11876	UniProtKB/Swiss-Prot
Pfam	Defensin_1	UniProtKB/Swiss-Prot
	Defensin_propep	UniProtKB/Swiss-Prot
PhenoGen	Defa10	PhenoGen
PIRSF	Alpha-defensin	UniProtKB/Swiss-Prot
PROSITE	DEFENSIN	UniProtKB/Swiss-Prot
SMART	Defensin_propep	UniProtKB/Swiss-Prot
	DEFSN	UniProtKB/Swiss-Prot
Superfamily-SCOP	Defensin-like	UniProtKB/Swiss-Prot
UniProt	DFA10_MOUSE	UniProtKB/Swiss-Prot, ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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