Ptmal3 (prothymosin alpha like 3) - Rat Genome Database

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Gene: Ptmal3 (prothymosin alpha like 3) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ptmal3 (Ensembl: Ptmal5)
Name: prothymosin alpha like 3 (Ensembl:prothymosin alpha like 5)
RGD ID: 1596138
Description: Predicted to enable histone binding activity. Predicted to be involved in negative regulation of apoptotic process and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human PTMA (prothymosin alpha).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: AABR07032862.1; hypothetical protein LOC689166; LOC689166; prothymosin alpha-like
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81884,704,624 - 84,704,965 (-)NCBIGRCr8
mRatBN7.21882,429,489 - 82,430,211 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1882,429,900 - 82,430,211 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl1383,921,044 - 83,922,040 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01886,278,967 - 86,279,822 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1886,279,179 - 86,279,680 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01885,317,674 - 85,318,200 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41886,044,172 - 86,044,483 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1880,980,218 - 80,981,081 (-)NCBICelera
Cytogenetic Map18q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Ptmal3
3 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
6903353Bp353Blood pressure QTL 3532.8arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)185979647883828827Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)185917211583828827Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647883828827Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000006169   ⟹   ENSRNOP00000054961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1882,429,900 - 82,430,211 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000051368   ⟹   ENSRNOP00000059708
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,921,044 - 83,922,040 (-)Ensembl
RefSeq Acc Id: XM_039097297   ⟹   XP_038953225
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81884,704,624 - 84,704,965 (-)NCBI
mRatBN7.21882,429,489 - 82,430,211 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038953225 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054961.2
  ENSRNOP00000059708.2
RefSeq Acc Id: XP_038953225   ⟸   XM_039097297
- UniProtKB: F1M034 (UniProtKB/TrEMBL),   A0A8L2UMZ6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000054961   ⟸   ENSRNOT00000006169
Ensembl Acc Id: ENSRNOP00000059708   ⟸   ENSRNOT00000051368

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M034-F1-model_v2 AlphaFold F1M034 1-156 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1596138 AgrOrtholog
BioCyc Gene G2FUF-6691 BioCyc
Ensembl Genes ENSRNOG00000004661 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000025731 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006169.5 UniProtKB/TrEMBL
  ENSRNOT00000051368.5 UniProtKB/TrEMBL
InterPro Pro/parathymosin UniProtKB/TrEMBL
NCBI Gene 689166 ENTREZGENE
PANTHER PROTHYMOSIN ALPHA UniProtKB/TrEMBL
  PTHR22745 UniProtKB/TrEMBL
Pfam Prothymosin UniProtKB/TrEMBL
PhenoGen Ptmal3 PhenoGen
RatGTEx ENSRNOG00000004661 RatGTEx
  ENSRNOG00000025731 RatGTEx
UniProt A0A8L2UMZ6 ENTREZGENE, UniProtKB/TrEMBL
  F1M034 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-10-13 Ptmal3  prothymosin alpha like 3  Ptmal1  prothymosin alpha like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2023-09-19 Ptmal1  prothymosin alpha like 1  LOC689166  hypothetical protein LOC689166  Symbol and Name Changed 1299863 APPROVED
2022-06-02 LOC689166  hypothetical protein LOC689166  AABR07032862.1    Data merged from RGD:15003282 737654 PROVISIONAL
2019-11-08 AABR07032862.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2006-11-20 LOC689166  hypothetical protein LOC689166      Symbol and Name status set to provisional 70820 PROVISIONAL