Lce1d (late cornified envelope 1D)

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Gene: Lce1d (late cornified envelope 1D) Rattus norvegicus

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General
Array IDs
References

Symbol:

Lce1d

Name:

late cornified envelope 1D

Description:

INVOLVED IN cellular response to calcium ion (ortholog); cognition (ortholog); FOUND IN cell periphery (ortholog); cornified envelope (ortholog); cytoplasm (ortholog); INTERACTS WITH bisphenol A; decabromodiphenyl ether; diuron

Type:

protein-coding

Also known as:

hypothetical protein LOC685981; LOC685981

Orthologs:

Homo sapiens (human) : LCE1D (late cornified envelope 1D) HGNC Alliance
Mus musculus (house mouse) : Lce1d (late cornified envelope 1D) MGI Alliance

more info ...

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LCE1D (late cornified envelope 1D)	HGNC	OMA, Panther
Mus musculus (house mouse):	Lce1d (late cornified envelope 1D)	HGNC	OMA

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

NCBI Annotation Information:

Genome Annotation Status: not in current annotation release

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
RGSC_v3.4	2	185,677,116 - 185,677,723 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	2	171,991,668 - 171,992,275 (-)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

Annotation (Toggle Annotation Detail/Summary View)

Gene-Chemical Interaction Annotations

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
17alpha-ethynylestradiol	multiple interactions	ISO	RGD:1618352	6480464	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LCE1D mRNA	CTD	PMID:17942748
2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	ISO	RGD:1618352	6480464	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LCE1D mRNA	CTD	PMID:17942748
arsenite(3-)	decreases methylation	ISO	RGD:1354412	6480464	arsenite results in decreased methylation of LCE1D promoter	CTD	PMID:23974009
arsenous acid	decreases expression	ISO	RGD:1618352	6480464	Arsenic Trioxide results in decreased expression of LCE1D mRNA	CTD	PMID:29095437
arsenous acid	multiple interactions	ISO	RGD:1618352	6480464	Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of LCE1D mRNA]	CTD	PMID:29095437
benzo[a]pyrene	affects expression	ISO	RGD:1354412	6480464	Benzo(a)pyrene affects the expression of LCE1D mRNA	CTD	PMID:21714911
beta-damascenone	increases expression	ISO	RGD:1618352	6480464	beta-damascenone results in increased expression of LCE1D mRNA	CTD	PMID:22982537
bis(2-chloroethyl) sulfide	increases expression	ISO	RGD:1354412	6480464	Mustard Gas results in increased expression of LCE1D mRNA	CTD	PMID:25102026
bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of LCE1D mRNA	CTD	PMID:25181051
carbon nanotube	increases expression	ISO	RGD:1354412	6480464	Nanotubes, Carbon results in increased expression of LCE1D mRNA	CTD	PMID:28673683
cyclosporin A	affects expression	ISO	RGD:1618352	6480464	Cyclosporine affects the expression of LCE1D mRNA	CTD	PMID:19770486
decabromodiphenyl ether	increases expression	EXP		6480464	decabromobiphenyl ether results in increased expression of LCE1D mRNA	CTD	PMID:23914054
diarsenic trioxide	multiple interactions	ISO	RGD:1618352	6480464	Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of LCE1D mRNA]	CTD	PMID:29095437
diarsenic trioxide	decreases expression	ISO	RGD:1618352	6480464	Arsenic Trioxide results in decreased expression of LCE1D mRNA	CTD	PMID:29095437
diclofenac	decreases expression	ISO	RGD:1618352	6480464	Diclofenac results in decreased expression of LCE1D mRNA	CTD	PMID:26934552
diuron	decreases expression	EXP		6480464	Diuron metabolite results in decreased expression of LCE1D mRNA	CTD	PMID:24172598
metformin	multiple interactions	ISO	RGD:1618352	6480464	Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of LCE1D mRNA]	CTD	PMID:29095437
paracetamol	decreases expression	ISO	RGD:1354412	6480464	Acetaminophen results in decreased expression of LCE1D mRNA	CTD	PMID:22230336
paracetamol	affects expression	ISO	RGD:1618352	6480464	Acetaminophen affects the expression of LCE1D mRNA	CTD	PMID:17562736

Gene Ontology Annotations

Biological Process

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
cellular response to calcium ion		ISO	RGD:1354412	1624291	(PMID:11698679)	RGD	PMID:11698679
cognition		ISO	RGD:1354412	1624291	(PMID:23227193)	RGD	PMID:23227193

Cellular Component

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
cell periphery		ISO	RGD:1618352	1624291	(MGI:MGI:2153216, PMID:11698679)	RGD	MGI:MGI:2153216, PMID:11698679
cornified envelope		ISO	RGD:1354412	1624291	(PMID:11698679)	RGD	PMID:11698679
cornified envelope		ISO	RGD:1618352	1624291	(MGI:MGI:2153216, PMID:11698679)	RGD	MGI:MGI:2153216, PMID:11698679
cytoplasm		ISO	RGD:1354412	1624291	(PMID:11698679)	RGD	PMID:11698679
perinuclear region of cytoplasm		ISO	RGD:1354412	1624291	(PMID:11698679)	RGD	PMID:11698679

Molecular Function

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
protein binding		ISO	RGD:1354412	1624291	UniProtKB:Q9BYS1 (PMID:27107012)	RGD	PMID:27107012

Gene-Chemical Interaction Annotations

	17alpha-ethynylestradiol (ISO)
	2,3,7,8-tetrachlorodibenzodioxine (ISO)
	arsenite(3-) (ISO)
	arsenous acid (ISO)
	benzo[a]pyrene (ISO)
	beta-damascenone (ISO)

	bis(2-chloroethyl) sulfide (ISO)
	bisphenol A (EXP)
	carbon nanotube (ISO)
	cyclosporin A (ISO)
	decabromodiphenyl ether (EXP)
	diarsenic trioxide (ISO)

	diclofenac (ISO)
	diuron (EXP)
	metformin (ISO)
	paracetamol (ISO)

Gene Ontology Annotations

Biological Process

	cellular response to calcium ion (ISO)
	cognition (ISO)

Cellular Component

	cell periphery (ISO)
	cornified envelope (ISO)

	cytoplasm (ISO)
	perinuclear region of cytoplasm (ISO)

Molecular Function

protein binding (ISO)

References - curated

1.	RGD automated import pipeline for gene-chemical interactions

References - uncurated

PubMed

11698679 21873635 23227193

Genomics

Comparative Map Data

Lce1d
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
RGSC_v3.4	2	185,677,116 - 185,677,723 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	2	171,991,668 - 171,992,275 (-)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

LCE1D
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	152,796,721 - 152,798,181 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	1	152,769,227 - 152,770,657 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	151,035,851 - 151,037,281 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	1	149,583,343 - 149,583,688	NCBI
Cytogenetic Map	1	q21.3	NCBI
CHM1_1	1	154,164,587 - 154,166,017 (+)	NCBI		CHM1_1

Lce1d
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm38	3	92,685,499 - 92,687,210 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
MGSCv37	3	92,489,421 - 92,491,132 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	3	92,770,902 - 92,772,613 (-)	NCBI			mm8
Celera	3	94,396,805 - 94,398,516 (+)	NCBI		Celera
Cytogenetic Map	3	F1	NCBI

Expression

Sequence

Nucleotide Sequences

Reference Sequences

RefSeq Acc Id:

XM_001066061 ⟹ XP_001066061

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
RGSC_v3.4	2	185,677,116 - 185,677,723 (+)	RGD

RefSeq Acc Id:

XM_002726006 ⟹ XP_002726052

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Celera	2	171,991,668 - 171,992,275 (-)	RGD

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	685981	ENTREZGENE
PhenoGen	Lce1d	PhenoGen

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Lce1d	late cornified envelope 1D	Lce1d_predicted	late cornified envelope 1D (predicted)	'predicted' is removed	2292626	APPROVED
2007-04-11	Lce1d_predicted	late cornified envelope 1D (predicted)	LOC685981	hypothetical protein LOC685981	Symbol and Name updated to reflect Human and Mouse nomenclature	1299863	APPROVED
2006-11-19	LOC685981	hypothetical protein LOC685981			Symbol and Name status set to provisional	70820	PROVISIONAL

More on Lce1d
	Alliance Gene
	NCBI Gene
	Ensembl Gene
	NCBI Genome Data Viewer

RGD Object Information
RGD ID:	1587794
Created:	2006-11-19
Species:	Rattus norvegicus
Last Modified:	2019-11-27
Status:	ACTIVE

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.