Hyal5 (hyaluronoglucosaminidase 5) - Rat Genome Database

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Gene: Hyal5 (hyaluronoglucosaminidase 5) Mus musculus
Analyze
No known orthologs.
Symbol: Hyal5
Name: hyaluronoglucosaminidase 5
RGD ID: 1557917
MGI Page MGI
Description: Enables hyalurononglucosaminidase activity. Acts upstream of or within penetration of zona pellucida. Located in acrosomal vesicle and external side of plasma membrane. Orthologous to human SPAM1 (sperm adhesion molecule 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4933439A12Rik; hyal-5; hyaluronidase Hyal-5; hyaluronidase PH-20; hyaluronidase-5
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39624,857,982 - 24,891,963 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl624,857,996 - 24,891,957 (+)EnsemblGRCm39 Ensembl
GRCm38624,857,937 - 24,891,959 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl624,857,997 - 24,891,958 (+)EnsemblGRCm38mm10GRCm38
MGSCv37624,807,997 - 24,841,958 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36624,808,007 - 24,841,968 (+)NCBIMGSCv36mm8
Celera624,868,624 - 24,902,481 (+)NCBICelera
Cytogenetic Map6A3.1NCBI
cM Map611.28NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14681479   PMID:16078272   PMID:16141072   PMID:16141073   PMID:16330764   PMID:16925524   PMID:19605784   PMID:19926939  
PMID:21267068   PMID:21873635   PMID:31670981  


Genomics

Variants

.
Variants in Hyal5
2077 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:36
Interacting mature miRNAs:41
Transcripts:ENSMUST00000031689
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
11353836Bmiq1_mbody mass index QTL 1 (mouse)6450382329751333Mouse
4140989Spqq2_msperm quality QTL 2 (mouse)Not determined1771159851711719Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080576983Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348703611Mouse
10043869Cia6a_mcollagen induced arthritis QTL 6a (mouse)Not determined61211797146118069Mouse
1301850Fglu_mfasting glucose (mouse)Not determined61771159851711719Mouse
4141749Obrq2_mobesity resistance QTL 2 (mouse)Not determined1275122146751333Mouse
1301724Pcd4ts1_mp-glycoprotein positive CD4 T cell subset 1 (mouse)Not determined61771159851711719Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
10412107Desp4_mdespair 4 (mouse)Not determined62004983054049830Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414773364675Mouse
1301131Chol2_mcholesterol 2 (mouse)Not determined6132144495Mouse
1302024Skull7_mskull morphology 7 (mouse)Not determined6132144495Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348703611Mouse
11353840Bmiq2_mbody mass index QTL 2 (mouse)6450382345291115Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
12904934Edlmmq4_mextensor digitorum longus muscle mass QTL 4 (mouse)6125514064Mouse
5491191Mobq2_mmultigenic obesity QTL 2 (mouse)Not determined6132144495Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
1300731Smdq3_msegregation of mitochondrial DNA QTL 3 (mouse)Not determined6424920638249325Mouse
12904940Edlmmq5_mextensor digitorum longus muscle mass QTL 5 (mouse)61961634653616346Mouse
15039372Nmrs22_mNAFLD-associated magnetic resonance shift 22 (mouse)6147633435476334Mouse
12904942Tammq3_mtibialis anterior muscle mass QTL 3 (mouse)6125514064Mouse
12904943Tammq4_mtibialis anterior muscle mass QTL 4 (mouse)61961634653616346Mouse
10412213Sxbq2_mSGC/Knj cross B6 QTL 2 (mouse)Not determined61991268571299759Mouse
1302051Sluc7_msusceptibility to lung cancer 7 (mouse)Not determined6929707443297168Mouse
14700690Ccs6_mcolon cancer susceptibility 6 (mouse)62377693457776934Mouse
27226726Tibmd7_mtibia midshaft diameter 7, 16 week (mouse)61769999953476985Mouse
12904952Gmmq4_mgastrocnemius muscle mass QTL 4 (mouse)61961634653616346Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348703611Mouse
1301998Bts2_mbladder tumor susceptibility 2 (mouse)Not determined61275122146751333Mouse
12904955Gmmq3_mgastrocnemius muscle mass QTL 3 (mouse)6125514064Mouse

Markers in Region
Hyal5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6A3.1UniSTS
cM Map611.28UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000031689   ⟹   ENSMUSP00000031689
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl624,875,908 - 24,891,804 (+)Ensembl
GRCm38.p6 Ensembl624,875,909 - 24,891,805 (+)Ensembl
Ensembl Acc Id: ENSMUST00000200968   ⟹   ENSMUSP00000144011
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl624,857,996 - 24,891,957 (+)Ensembl
GRCm38.p6 Ensembl624,857,997 - 24,891,958 (+)Ensembl
Ensembl Acc Id: ENSMUST00000201585
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl624,890,536 - 24,891,744 (+)Ensembl
GRCm38.p6 Ensembl624,890,537 - 24,891,745 (+)Ensembl
RefSeq Acc Id: NM_001417847   ⟹   NP_001404776
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39624,857,982 - 24,891,963 (+)NCBI
RefSeq Acc Id: NM_001417848   ⟹   NP_001404777
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39624,857,982 - 24,891,963 (+)NCBI
RefSeq Acc Id: NM_001417849   ⟹   NP_001404778
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39624,890,510 - 24,891,963 (+)NCBI
RefSeq Acc Id: NM_028957   ⟹   NP_083233
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39624,857,982 - 24,891,963 (+)NCBI
GRCm38624,857,997 - 24,891,958 (+)NCBI
MGSCv37624,807,997 - 24,841,958 (+)RGD
Celera624,868,624 - 24,902,481 (+)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_083233   ⟸   NM_028957
- Peptide Label: isoform a precursor
- UniProtKB: Q812F3 (UniProtKB/TrEMBL),   Q9CUA5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000031689   ⟸   ENSMUST00000031689
Ensembl Acc Id: ENSMUSP00000144011   ⟸   ENSMUST00000200968
RefSeq Acc Id: NP_001404777   ⟸   NM_001417848
- Peptide Label: isoform b
RefSeq Acc Id: NP_001404776   ⟸   NM_001417847
- Peptide Label: isoform a precursor
- UniProtKB: Q812F3 (UniProtKB/Swiss-Prot),   Q9CUA5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001404778   ⟸   NM_001417849
- Peptide Label: isoform c

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q812F3-F1-model_v2 AlphaFold Q812F3 1-526 view protein structure

Promoters
RGD ID:6889124
Promoter ID:EPDNEW_M8013
Type:initiation region
Name:Hyal5_1
Description:Mus musculus hyaluronoglucosaminidase 5 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8014  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38624,857,983 - 24,858,043EPDNEW
RGD ID:6889126
Promoter ID:EPDNEW_M8014
Type:initiation region
Name:Hyal5_2
Description:Mus musculus hyaluronoglucosaminidase 5 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8013  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38624,863,907 - 24,863,967EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1921718 AgrOrtholog
Ensembl Genes ENSMUSG00000029678 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000031689 ENTREZGENE
  ENSMUST00000031689.6 UniProtKB/Swiss-Prot
  ENSMUST00000200968 ENTREZGENE
  ENSMUST00000200968.4 UniProtKB/Swiss-Prot
Gene3D-CATH 3.20.20.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aldolase_TIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hyaluronidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hyaluronidase_PH20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:74468 UniProtKB/Swiss-Prot
MGD MGI:1921718 ENTREZGENE
NCBI Gene 74468 ENTREZGENE
PANTHER HYALURONIDASE PH-20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11769 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Glyco_hydro_56 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hyal5 PhenoGen
PIRSF Hyaluronidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hyaluronidase_PH20_Hyal5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS GLHYDRLASE56 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPERMPH20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51445 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt HYAL5_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q9CUA5 ENTREZGENE, UniProtKB/TrEMBL