LOC127829170 (H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:31782018-31782667) - Rat Genome Database

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Gene: LOC127829170 (H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:31782018-31782667) Homo sapiens
Analyze
Symbol: LOC127829170
Name: H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:31782018-31782667
RGD ID: 155781105
Description: This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells, where it is marked by the H3K27ac and H3K4me1 histone modifications. An accessible chromatin subregion was used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. That subregion was identified as a functional silencer in phorbol 12-myristate 13-acetate-treated (for megakaryocytic differentiation) K562 erythroleukemia cells. [provided by RefSeq, Jun 2023]
Type: biological-region
RefSeq Status: REVIEWED
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381531,489,815 - 31,490,464 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371531,782,018 - 31,782,667 (+)NCBIGRCh37GRCh37hg19GRCh37
T2T-CHM13v2.01529,284,165 - 29,284,814 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:30033119   PMID:32094911  


Genomics


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2289410BW327_HBody weight QTL 327 (human)3.320.0001Body fat amount151998012945980129Human
1643273BW330_HBody Weight QTL 330 (human)1.050.014Body weightbody mass index152686671952866719Human
2289430BMD7_HBone mineral density QTL 7 (human)3.320.0001Bone mineral density151998012945980129Human
1559411SCL107_HSerum cholesterol level QTL 107 (human)3.88Lipid leveltriglyceride152654355252543552Human
1643523BW284_HBody Weight QTL 284 (human)1.950.0013Body weight152179288947792889Human
2289420BW314_HBody weight QTL 314 (human)2.720.0003Body weightlean mass151998012945980129Human


Expression

RNA-SEQ Expression


Sequence



Additional Information

Database Acc Id Source(s)
COSMIC LOC127829170 COSMIC
GTEx LOC127829170 GTEx
Human Proteome Map LOC127829170 Human Proteome Map
NCBI Gene LOC127829170 ENTREZGENE