LOC127829093 (OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:29120985-29121605)

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Gene: LOC127829093 (OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:29120985-29121605) Homo sapiens

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Symbol:

LOC127829093

Name:

OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:29120985-29121605

RGD ID:

155769989

Description:

This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive and primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Nov 2022]

Type:

biological-region

RefSeq Status:

REVIEWED

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	28,875,839 - 28,876,459 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	15	29,120,985 - 29,121,605 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
T2T-CHM13v2.0	15	26,652,841 - 26,653,461 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

References

Additional References at PubMed

PMID:30033119

Genomics

QTLs in Region (GRCh38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2289410	BW327_H	Body weight QTL 327 (human)	3.32	0.0001	Body fat amount		15	19980129	45980129	Human
1643273	BW330_H	Body Weight QTL 330 (human)	1.05	0.014	Body weight	body mass index	15	26866719	52866719	Human
2289430	BMD7_H	Bone mineral density QTL 7 (human)	3.32	0.0001	Bone mineral density		15	19980129	45980129	Human
1559411	SCL107_H	Serum cholesterol level QTL 107 (human)	3.88		Lipid level	triglyceride	15	26543552	52543552	Human
1643523	BW284_H	Body Weight QTL 284 (human)	1.95	0.0013	Body weight		15	21792889	47792889	Human
2289420	BW314_H	Body weight QTL 314 (human)	2.72	0.0003	Body weight	lean mass	15	19980129	45980129	Human

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NG_130575	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC174071	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AMYH02030123	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068263	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Additional Information

External Database Links

Database	Acc Id	Source(s)
COSMIC	LOC127829093	COSMIC
GTEx	LOC127829093	GTEx
Human Proteome Map	LOC127829093	Human Proteome Map
NCBI Gene	LOC127829093	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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