Lyz3 (lysozyme 3) - Rat Genome Database

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Gene: Lyz3 (lysozyme 3) Mus musculus
Analyze
No known orthologs.
Symbol: Lyz3
Name: lysozyme 3
RGD ID: 1315112
MGI Page MGI
Description: Predicted to enable identical protein binding activity and lysozyme activity. Predicted to be involved in defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; and killing of cells of another organism. Predicted to be located in extracellular space. Is expressed in skeleton. Orthologous to human LYZ (lysozyme).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9530003J23Rik; hypothetical protein LOC77397; lysozyme C-like; lysozyme f1; Lyzf1
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910117,069,658 - 117,074,586 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10117,068,142 - 117,074,608 (-)EnsemblGRCm39 Ensembl
GRCm3810117,233,753 - 117,238,681 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10117,232,237 - 117,238,703 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710116,670,809 - 116,675,737 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610116,637,869 - 116,642,716 (-)NCBIMGSCv36mm8
Celera10119,176,780 - 119,181,708 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1065.28NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11752298   PMID:12477932   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21873635   PMID:38355793  


Genomics

Variants

.
Variants in Lyz3
102 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:377
Count of miRNA genes:279
Interacting mature miRNAs:305
Transcripts:ENSMUST00000020392, ENSMUST00000159193
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301520Uvbi1_mUVB induced immunosuppression 1 (mouse)Not determined1086909085120909229Mouse
26884377Skwq3_mskull length QTL 3, 5 week (mouse)10114635905122735905Mouse
26884383Bzwq3_mbi-zygomatic width QTL 3, 5 week (mouse)10114235905122735905Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
4142386Tgq20_mtriglyceride QTL 20 (mouse)Not determined88836456122836456Mouse
1357594Estoq3_membryo survival total QTL 3 (mouse)Not determined1084079650122041528Mouse
4141361Cfmq3_mcystic fibrosis modifier QTL 3 (mouse)Not determined10101497164130530862Mouse
4141487Tgq21_mtriglyceride QTL 21 (mouse)Not determined104110021130530862Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
1301895Exq1_mexploratory and excitability QTL 1 (mouse)Not determined10102847852130530862Mouse
14746996Manh69_mmandible shape 69 (mouse)10104763638130530862Mouse
4141479W10q8_mweight 10 weeks QTL 8 (mouse)Not determined84079650122041528Mouse
1301901Im5_mimmunoregulatory 5 (mouse)Not determined10101497164130530862Mouse
4142496W6q8_mweight 6 weeks QTL 8 (mouse)Not determined84079650122041528Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
11039496Ltpr5b_mLeishmania tropica response 5b (mouse)10108575094130530862Mouse
1357622Espq3_membryo survival preimplantation QTL 3 (mouse)Not determined1084079650122041528Mouse
4142365Egq9_mearly growth QTL 9 (mouse)Not determined84079650122041528Mouse
13208554Lgth11_mbody length 11 (mouse)1090835862120835905Mouse
1357744Cfbw4_mcystic fibrosis body weight 4 (mouse)Not determined10100986516130530862Mouse
11041664Lmr25_mleishmaniasis resistance 25 (mouse)10108575094130530862Mouse
1300921Skl4_mskeletal size (tail length) 4 (mouse)Not determined1088088254122088391Mouse
1302200Sle12_msystematic lupus erythematosus susceptibility 12 (mouse)Not determined10105041304130530862Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
1300797Sluc22_msusceptibility to lung cancer 22 (mouse)Not determined1086713608120713756Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
1300796Lmr5_mleishmaniasis resistance 5 (mouse)Not determined10116220635122179828Mouse
10412078Hylaq3_mHyperlocomotor activity related QTL 3 (mouse)Not determined10111568226117986649Mouse
11039516Ltpr5_mLeishmania tropica response 5 (mouse)1090506901125575232Mouse
4142089Obrq9_mobesity resistance QTL 9 (mouse)Not determined108515907130530862Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse
26884391Skwq11_mskull length QTL 11, 16 week (mouse)10113535905121635905Mouse
13506931Recrq11_mrecombination rate in male meiosis QTL 11 (mouse)10114335905123635905Mouse
1357482Nhdlq4_mnon-HDL QTL 4 (mouse)Not determined10105041304130530862Mouse
1300908Insq4_minsulin QTL 4 (mouse)Not determined1086909085120909229Mouse
4142461Bmd25_mbone mineral density 25 (mouse)Not determined1097217101130530862Mouse
1301968Estq4_mestradiol regulated response QTL 4 (mouse)Not determined10100986516130530862Mouse
27095902Scvln11_msacral vertebrae length 2, 10 week (mouse)10110035861125435869Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1073987216125515907Mouse
1357779Tesq3_mtestis weight QTL 3 (mouse)Not determined1084079650122041528Mouse
11049570Lmr25b_mleishmaniasis resistance 25b (mouse)10108575094130530862Mouse
26884433Zlq2_mzygomatic length QTL 2, 5 week (mouse)10113535905125735869Mouse
11533921Mvb2_mmodifier of vibrator 2 (mouse)1097217101130530862Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
1357638Cia29_mcollagen induced arthritis 29 (mouse)Not determined1085454982118497353Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1067835830124835905Mouse
1300679Nociq2_mnociceptive sensitivity inflammatory QTL 2 (mouse)Not determined10105041304130530862Mouse
1300678Leg2_mlongevity extending gene 2 (mouse)Not determined10102506908130530862Mouse
12880413V125Dq9_mvitamin D active form serum level QTL 9 (mouse)1097535905130530862Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1073987216125515907Mouse
4141153Ltgq2_mliver triglyceride QTL 2 (mouse)Not determined108515907130530862Mouse
4141402T2dm1sa_mtype 2 diabetes mellitus 1 in SMXA RI mice (mouse)Not determined97758644130530862Mouse
4141269Ipng2_mimprinted postnatal growth 2 (mouse)Not determined105088254118497353Mouse
1301758Fcsa3_mfemoral cross-sectional area 3 (mouse)Not determined1089927651123927754Mouse
11533919Mvb4_mmodifier of vibrator 4 (mouse)397217101130530862Mouse
4141007Obrq10_mobesity resistance QTL 10 (mouse)Not determined103243727130530862Mouse
11353823Homaq2_mhomeostatic model assessment QTL 2 (mouse)10110453347125515907Mouse
11049563Lmr25a_mleishmaniasis resistance 25a (mouse)10108575094130530862Mouse
11353822Insq12_minsulin QTL 12 (mouse)10110453347125515907Mouse
4141387Lgaq5_mlate growth adjusted QTL 5 (mouse)Not determined84079650122041528Mouse
14696727Kidrq2_mkidney weight, right QTL 2 (mouse)10102902508130530862Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
11040593Lmr5e_mleishmaniasis resistance 5e (mouse)1099220635130530862Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
27226725Tibw1_mtibia width 1, proximal, 5 week (mouse)10102735861123235905Mouse
11040594Lmr5f_mleishmaniasis resistance 5f (mouse)10105179713130530862Mouse
11040595Lmr5c_mleishmaniasis resistance 5c (mouse)1099220635130530862Mouse
1357544Vtbt10_mvertebral trabecular bone trait 10 (mouse)Not determined1097217101130530862Mouse
11040596Lmr5d_mleishmaniasis resistance 5d (mouse)10105179713130530862Mouse
11040597Lmr5a_mleishmaniasis resistance 5a (mouse)1099220635130530862Mouse
27226722Tibw7_mtibia width 7, proximal, 16 week (mouse)10108635861125435869Mouse
11040598Lmr5b_mleishmaniasis resistance 5b (mouse)10105179713130530862Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000020392   ⟹   ENSMUSP00000020392
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10117,069,666 - 117,074,608 (-)Ensembl
GRCm38.p6 Ensembl10117,233,761 - 117,238,703 (-)Ensembl
Ensembl Acc Id: ENSMUST00000159193   ⟹   ENSMUSP00000125436
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10117,068,142 - 117,074,559 (-)Ensembl
GRCm38.p6 Ensembl10117,232,237 - 117,238,654 (-)Ensembl
RefSeq Acc Id: NM_029906   ⟹   NP_084182
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910117,069,658 - 117,074,586 (-)NCBI
GRCm3810117,233,753 - 117,238,681 (-)NCBI
MGSCv3710116,670,809 - 116,675,737 (-)RGD
Celera10119,176,780 - 119,181,708 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_084182   ⟸   NM_029906
- Peptide Label: precursor
- UniProtKB: Q8BM26 (UniProtKB/TrEMBL),   Q9D249 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000125436   ⟸   ENSMUST00000159193
Ensembl Acc Id: ENSMUSP00000020392   ⟸   ENSMUST00000020392
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BM26-F1-model_v2 AlphaFold Q8BM26 1-151 view protein structure

Promoters
RGD ID:8673324
Promoter ID:EPDNEW_M14693
Type:multiple initiation site
Name:9530003J23Rik_1
Description:Mus musculus RIKEN cDNA 9530003J23 gene , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3810117,238,606 - 117,238,666EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1924647 AgrOrtholog
Ensembl Genes ENSMUSG00000020177 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000020392 ENTREZGENE
  ENSMUST00000020392.5 UniProtKB/TrEMBL
  ENSMUST00000159193.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.530.10 UniProtKB/TrEMBL
InterPro Glyco_hydro_22 UniProtKB/TrEMBL
  Glyco_hydro_22_CS UniProtKB/TrEMBL
  Glyco_hydro_22_lys UniProtKB/TrEMBL
  Lysozyme-like_dom UniProtKB/TrEMBL
KEGG Report mmu:77397 UniProtKB/TrEMBL
MGD MGI:1924647 ENTREZGENE
NCBI Gene 77397 ENTREZGENE
PANTHER 9530003J23RIK PROTEIN UniProtKB/TrEMBL
  PTHR11407 UniProtKB/TrEMBL
Pfam Lys UniProtKB/TrEMBL
PhenoGen Lyz3 PhenoGen
PRINTS LYSOZYME UniProtKB/TrEMBL
  LYZLACT UniProtKB/TrEMBL
PROSITE LACTALBUMIN_LYSOZYME_1 UniProtKB/TrEMBL
  LACTALBUMIN_LYSOZYME_2 UniProtKB/TrEMBL
SMART LYZ1 UniProtKB/TrEMBL
Superfamily-SCOP SSF53955 UniProtKB/TrEMBL
UniProt Q8BM26 ENTREZGENE, UniProtKB/TrEMBL
  Q8BM27_MOUSE UniProtKB/TrEMBL
  Q9D249 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-01-16 Lyz3  lysozyme 3  9530003J23Rik  RIKEN cDNA 9530003J23 gene  Symbol and/or name updated 27372883 PROVISIONAL