Gpr63 (G protein-coupled receptor 63) - Rat Genome Database

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Gene: Gpr63 (G protein-coupled receptor 63) Mus musculus
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Symbol: Gpr63
Name: G protein-coupled receptor 63
RGD ID: 1315092
MGI Page MGI
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of receptor complex. Is expressed in gut; male reproductive gland or organ; metanephros; nervous system; and thymus. Orthologous to human GPR63 (G protein-coupled receptor 63).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G protein-coupled receptor PSP24-2; probable G-protein coupled receptor 63; PSP24; Psp24-2; PSP24-beta; PSP24beta
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39424,966,054 - 25,012,726 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl424,966,407 - 25,009,233 (+)EnsemblGRCm39 Ensembl
GRCm38424,966,054 - 25,009,238 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl424,966,407 - 25,009,233 (+)EnsemblGRCm38mm10GRCm38
MGSCv37424,900,566 - 24,936,380 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36425,064,049 - 25,099,863 (+)NCBIMGSCv36mm8
Celera424,708,676 - 24,744,420 (+)NCBICelera
Cytogenetic Map4A3NCBI
cM Map410.53NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA,ISO)
membrane  (ISS)
nucleoplasm  (IEA,ISO)
plasma membrane  (IEA,ISO)
receptor complex  (ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11027574   PMID:11042159   PMID:11076861   PMID:11217851   PMID:16141072   PMID:16141073   PMID:16602821   PMID:19000842   PMID:21677750   PMID:21873635   PMID:23382219  
PMID:24194600   PMID:27626380   PMID:31730647   PMID:38355793  


Genomics

Comparative Map Data
Gpr63
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39424,966,054 - 25,012,726 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl424,966,407 - 25,009,233 (+)EnsemblGRCm39 Ensembl
GRCm38424,966,054 - 25,009,238 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl424,966,407 - 25,009,233 (+)EnsemblGRCm38mm10GRCm38
MGSCv37424,900,566 - 24,936,380 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36425,064,049 - 25,099,863 (+)NCBIMGSCv36mm8
Celera424,708,676 - 24,744,420 (+)NCBICelera
Cytogenetic Map4A3NCBI
cM Map410.53NCBI
GPR63
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38696,794,125 - 96,837,477 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl696,794,125 - 96,837,477 (-)EnsemblGRCh38hg38GRCh38
GRCh37697,242,001 - 97,285,353 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36697,352,645 - 97,391,921 (-)NCBINCBI36Build 36hg18NCBI36
Build 34697,352,644 - 97,391,921NCBI
Celera697,887,934 - 97,927,394 (-)NCBICelera
Cytogenetic Map6q16.1NCBI
HuRef694,676,127 - 94,719,548 (-)NCBIHuRef
CHM1_1697,504,013 - 97,547,361 (-)NCBICHM1_1
T2T-CHM13v2.0697,965,926 - 98,009,403 (-)NCBIT2T-CHM13v2.0
Gpr63
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8543,469,112 - 43,523,840 (+)NCBIGRCr8
mRatBN7.2538,672,548 - 38,727,224 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl538,635,472 - 38,727,677 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx540,787,318 - 40,823,322 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0542,386,331 - 42,422,340 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0542,319,665 - 42,355,667 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0539,258,438 - 39,374,187 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl539,329,423 - 39,370,900 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0543,949,612 - 44,003,200 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4540,016,167 - 40,061,157 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1540,059,336 - 40,060,614 (+)NCBI
Celera537,616,312 - 37,658,818 (+)NCBICelera
Cytogenetic Map5q21NCBI
Gpr63
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541122,771,570 - 22,817,906 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541122,771,570 - 22,817,906 (-)NCBIChiLan1.0ChiLan1.0
GPR63
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25116,829,172 - 116,877,745 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16114,712,752 - 114,755,919 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0694,628,451 - 94,672,303 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1698,514,564 - 98,558,140 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl698,518,928 - 98,520,187 (-)Ensemblpanpan1.1panPan2
GPR63
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11255,205,481 - 55,213,395 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1255,209,494 - 55,210,753 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1255,024,972 - 55,074,561 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01256,021,814 - 56,071,226 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1256,021,914 - 56,071,276 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11255,357,194 - 55,406,740 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01255,218,468 - 55,267,635 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01255,466,527 - 55,515,939 (-)NCBIUU_Cfam_GSD_1.0
Gpr63
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494689,787,765 - 89,831,835 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936699896,546 - 936,518 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936699896,524 - 937,176 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR63
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl163,911,310 - 63,973,869 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1163,911,304 - 63,974,415 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2172,280,844 - 72,343,404 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPR63
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11377,074,748 - 77,121,217 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1377,115,603 - 77,116,862 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604049,376,887 - 49,421,466 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpr63
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248108,522,520 - 8,581,999 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248108,522,227 - 8,584,824 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpr63
1719 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:370
Count of miRNA genes:285
Interacting mature miRNAs:316
Transcripts:ENSMUST00000038920, ENSMUST00000151006
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301203Alcp8_malcohol preference locus 8 (mouse)Not determined41739516051395290Mouse
10401115Pgia35_mproteoglycan induced arthritis 35 (mouse)Not determined41256237746562509Mouse
39128211Lwq22_mliver weight QTL 22 (mouse)41789261688982216Mouse
1558992Ses8_msalmonella enteritidis susceptibility 8 (mouse)Not determined4868324042683429Mouse
4141302Ssrq5_mstress response QTL 5 (mouse)Not determined868324042683430Mouse
4141555Nbwa2_mNZB and NZW autoimmunity 2 (mouse)Not determined41789251551892635Mouse
4142318Lyr2_mlymphoma resistance 2 (mouse)Not determined1401045763283678Mouse
12880405Jcdq1_mjoint cartilage degeneration QTL 1 (mouse)41256237746562509Mouse
1301697Sluc18_msusceptibility to lung cancer 18 (mouse)Not determined42237344856373612Mouse
1301510Bbaa13_mB.burgdorferi-associated arthritis 13 (mouse)Not determined4126395649Mouse
1357453Kidq4_mkidney weight QTL 4 (mouse)Not determined41789261688982216Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
25440481Moaq1_mmodifier of alien QTL 1 (mouse)41950000046000000Mouse
1301237Alcp7_malcohol preference locus 7 (mouse)Not determined41739516051395290Mouse
1302075Bdln6_mbody length 6 (mouse)Not determined42237344856373612Mouse
4141911W6q15_mweight 6 weeks QTL 15 (mouse)Not determined1789261688982216Mouse
1302010Wta1_mweight adult 1 (mouse)Not determined4868324042683429Mouse
1301437Scon1_msucrose consumption 1 (mouse)Not determined42237344856373612Mouse
10401905Sicd3_mseizure-induced cell death 3 (mouse)Not determined4939552543760862Mouse
1301473Triglq1_mtriglyceride QTL 1 (mouse)Not determined4868324042683429Mouse
1300769Pcyts2_mplasmacytoma susceptibility 2 (mouse)Not determined42211194456112145Mouse
1302058Hrtfm3_mheart failure modifier 3 (mouse)Not determined42211194456112145Mouse
1302184Aaom1_mautoimmune aoritis in MRL mice 1 (mouse)Not determined42432229946332776Mouse
1302125Lxw1_mlupus BXSB x NZW 1 (mouse)Not determined4868324042683429Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000038920   ⟹   ENSMUSP00000039312
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl424,973,419 - 25,009,233 (+)Ensembl
GRCm38.p6 Ensembl424,973,419 - 25,009,233 (+)Ensembl
Ensembl Acc Id: ENSMUST00000151006
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl424,966,407 - 25,007,300 (+)Ensembl
GRCm38.p6 Ensembl424,966,407 - 25,007,300 (+)Ensembl
RefSeq Acc Id: NM_001379626   ⟹   NP_001366555
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39424,966,440 - 25,009,238 (+)NCBI
GRCm38424,966,440 - 25,009,238 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001379627   ⟹   NP_001366556
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39424,966,054 - 25,009,238 (+)NCBI
GRCm38424,966,054 - 25,009,238 (+)NCBI
Sequence:
RefSeq Acc Id: NM_030733   ⟹   NP_109658
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39424,973,419 - 25,009,238 (+)NCBI
GRCm38424,973,419 - 25,009,238 (+)NCBI
MGSCv37424,900,566 - 24,936,380 (+)RGD
Celera424,708,676 - 24,744,420 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006538383   ⟹   XP_006538446
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39424,966,994 - 25,012,726 (+)NCBI
GRCm38424,966,993 - 25,009,229 (+)NCBI
Sequence:
RefSeq Acc Id: NP_109658   ⟸   NM_030733
- UniProtKB: Q8BZ93 (UniProtKB/Swiss-Prot),   Q9EQQ3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006538446   ⟸   XM_006538383
- Peptide Label: isoform X1
- UniProtKB: Q8BZ93 (UniProtKB/Swiss-Prot),   Q9EQQ3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001366556   ⟸   NM_001379627
- UniProtKB: Q9EQQ3 (UniProtKB/Swiss-Prot),   Q8BZ93 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001366555   ⟸   NM_001379626
- UniProtKB: Q9EQQ3 (UniProtKB/Swiss-Prot),   Q8BZ93 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSMUSP00000039312   ⟸   ENSMUST00000038920

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EQQ3-F1-model_v2 AlphaFold Q9EQQ3 1-425 view protein structure

Promoters
RGD ID:6836247
Promoter ID:MM_KWN:36883
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:MEF_B4
Transcripts:OTTMUST00000010828,   OTTMUST00000010852
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36424,893,456 - 24,893,956 (+)MPROMDB
RGD ID:6882944
Promoter ID:EPDNEW_M4923
Type:single initiation site
Name:Gpr63_1
Description:Mus musculus G protein-coupled receptor 63 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38424,995,499 - 24,995,559EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2135884 AgrOrtholog
Ensembl Genes ENSMUSG00000040372 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000038920 ENTREZGENE
  ENSMUST00000038920.2 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPC_Orphan_Receptors UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report mmu:81006 UniProtKB/Swiss-Prot
MGD MGI:2135884 ENTREZGENE
NCBI Gene 81006 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
  G-PROTEIN COUPLED RECEPTOR 63-RELATED UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Gpr63 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt GPR63_MOUSE UniProtKB/Swiss-Prot
  Q8BZ93 ENTREZGENE
  Q9EQQ3 ENTREZGENE
UniProt Secondary Q8BZ93 UniProtKB/Swiss-Prot