CVCL_XB36 - Rat Genome Database

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Cell Line : CVCL_XB36 (PLC/PRF/5-Cas9-709) Homo sapiens

Symbol: CVCL_XB36
Name: PLC/PRF/5-Cas9-709
RGD ID: 21193692
Cell Line Type: cancer cell line
Origin: Population: African; Shangaan; Karyotypic information: Has lost chromosome Y (from parent cell line); Transformant: Hepatitis B virus (HBV)(NCBI-Taxonomy; 10407); Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Gender: Male
Characteristics: Characteristics: Transfected with a Cas9-Flag-Neo construct
Genomic Alteration: Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg112Gly (c.334C>G) (p.Pro126Arg, c.377C>G); ClinVar=VCV000233484; Zygosity=Homozygous (from parent cell line); Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg249Ser (c.747G>T); ClinVar=VCV000012352; Zygosity=Homozygous (from parent cell line); Sequence variation: Mutation; HGNC; 12363; TSC2; Simple; p.Asn1651Ser (c.4952A>G); ClinVar=VCV000049335; Zygosity=Homozygous (from parent cell line); Transfected with: UniProtKB; Q99ZW2; Streptomyces pyogenes Cas9; Transfected with: UniProtKB; P00552; Transposon Tn5 neo
Derived From Cell Lines: CVCL_0485 (PLC/PRF/5)
Disease(s): adult hepatocellular carcinoma (DOID:0070328) [NCI:C7956,ORDO:210159]

References

Additional Information

Database Acc Id Source(s)
cancercelllines CVCL_XB36 CELLOSAURUS
CCRID 1101HUM-PUMC000709 CELLOSAURUS
Cellosaurus CVCL_XB36 CELLOSAURUS
NCIt C7956 CELLOSAURUS
Orphanet 210159 CELLOSAURUS
Wikidata Q98128625 CELLOSAURUS