CVCL_0497 - Rat Genome Database

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Cell Line : CVCL_0497 (SNU-475) Homo sapiens

Symbol: CVCL_0497
Name: SNU-475
RGD ID: 21119458
Cell Line Type: cancer cell line
Origin: Population: Korean; Karyotypic information: Has lost chromosome Y; Transformant: Hepatitis B virus (HBV)(NCBI-Taxonomy; 10407); Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Gender: Male
Research Use: Omics: Array-based CGH; Omics: Deep exome analysis; Omics: Deep quantitative proteome analysis; Omics: DNA methylation analysis; Omics: Genome sequenced; Omics: miRNA expression profiling; Omics: Protein expression by reverse-phase protein arrays; Omics: SNP array analysis; Omics: Transcriptome analysis by microarray; Omics: Transcriptome analysis by RNAseq
Phenotype: Doubling time: 66 hours (PubMed=7543080); 35.6 hours (PubMed=31378681); Microsatellite instability: Stable (MSS) (Sanger)
Genomic Alteration: Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=31068700); Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Asn239Asp (c.715A>G); ClinVar=VCV000234036; Zygosity=Heterozygous (PubMed=8824565; Cosmic-CLP; DepMap); Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Gly262Asp (c.785G>A); Zygosity=Heterozygous (Cosmic-CLP; DepMap); Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Cys275Arg (c.823T>C); ClinVar=VCV000376584; Zygosity=Unspecified (PubMed=8824565); Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Asn288Ser (c.863A>G); Zygosity=Unspecified (PubMed=8824565)
Groups: Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE); Part of: COSMIC cell lines project; Part of: Liver Cancer Model Repository (LIMORE); Part of: MD Anderson Cell Lines Project; Part of: Seoul National University (SNU) cell line collection
Description: HLA typing: A*02:01,11:01; B*40:02,54:01; C*03:04,03:04 (PubMed=26589293); Genome ancestry: African=0.39%; Native American=0%; East Asian, North=63.9%; East Asian, South=34.56%; South Asian=0%; European, North=0%; European, South=1.15% (PubMed=30894373)
Child Cell Lines: CVCL_C9G6 (SNU-475/Cas9-hyg)
Aliases: NCI-SNU-475; SNU475
Disease(s): adult hepatocellular carcinoma (DOID:0070328) [NCI:C7956,ORDO:210159]

References
Additional References at PubMed
PMID:7543080   PMID:8824565   PMID:16616112   PMID:19956504   PMID:20164919   PMID:20215515   PMID:22460905   PMID:23505090   PMID:23887712   PMID:25485619   PMID:25574106   PMID:25877200  
PMID:26589293   PMID:27397505   PMID:28196595   PMID:30894373   PMID:31063779   PMID:31068700   PMID:31378681   PMID:35839778  


Additional Information

Database Acc Id Source(s)
ArrayExpress E-MTAB-2706 CELLOSAURUS
  E-MTAB-2770 CELLOSAURUS
  E-MTAB-3610 CELLOSAURUS
  E-MTAB-38 CELLOSAURUS
  E-MTAB-783 CELLOSAURUS
ATCC CRL-2236 CELLOSAURUS
BioGRID_ORCS_Cell_line 811 CELLOSAURUS
BioSample SAMN03471846 CELLOSAURUS
  SAMN03473134 CELLOSAURUS
  SAMN10987958 CELLOSAURUS
BTO BTO_0003189 CELLOSAURUS
cancercelllines CVCL_0497 CELLOSAURUS
Cell Line Ontology CLO_0009101 CELLOSAURUS
Cell Model Passports SIDM01196 CELLOSAURUS
Cellosaurus CVCL_0497 CELLOSAURUS
ChEMBL-Cells CHEMBL3308787 CELLOSAURUS
ChEMBL-Targets CHEMBL1075586 CELLOSAURUS
COSMIC Samples 2023871 CELLOSAURUS
  2162533 CELLOSAURUS
  2321038 CELLOSAURUS
  684201 CELLOSAURUS
  871512 CELLOSAURUS
  873403 CELLOSAURUS
  909739 CELLOSAURUS
  928145 CELLOSAURUS
Cosmic-CLP 909739 CELLOSAURUS
DepMap ACH-000422 CELLOSAURUS
EFO EFO_0002350 CELLOSAURUS
EGA EGAS00001000610 CELLOSAURUS
  EGAS00001000978 CELLOSAURUS
GDSC 909739 CELLOSAURUS
GEO GSM1670472 CELLOSAURUS
  GSM2551590 CELLOSAURUS
  GSM481449 CELLOSAURUS
  GSM565920 CELLOSAURUS
  GSM887630 CELLOSAURUS
  GSM888715 CELLOSAURUS
  GSM936783 CELLOSAURUS
IGRhCellID SNU475 CELLOSAURUS
KCLB 00475 CELLOSAURUS
LiGeA CCLE_299 CELLOSAURUS
LINCS_LDP LCL-1937 CELLOSAURUS
Lonza 452 CELLOSAURUS
NCIt C7956 CELLOSAURUS
Orphanet 210159 CELLOSAURUS
PharmacoDB SNU475_1465_2019 CELLOSAURUS
PRIDE PXD030304 CELLOSAURUS
Progenetix CVCL_0497 CELLOSAURUS
Wikidata Q54955204 CELLOSAURUS