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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737501
Species: Homo sapiens
RGD Object: Gene
Symbol: PKM
Name: pyruvate kinase M1/2
Acc ID: CHEBI:9168
Term: sirolimus
Definition: A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Chemical ID: MESH:D020123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PKMincreases expressionEXP 6480464CTDSirolimus results in increased expression of PKM proteinPMID:36640941
PKMmultiple interactionsEXP 6480464CTD[Sirolimus results in decreased activity of MTOR protein] which results in decreased expression of PKM protein; Curcumin inhibits the reaction [Sirolimus results in increased expression of PKM protein]; Sirolimus inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PKM protein]PMID:22574221 PMID:36336208 PMID:36640941
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