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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737321
Species: Homo sapiens
RGD Object: Gene
Symbol: PROC
Name: protein C, inactivator of coagulation factors Va and VIIIa
Acc ID: CHEBI:10033
Term: warfarin
Definition: A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.
Chemical ID: MESH:D014859
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PROCaffects response to substanceEXP 6480464CTDPROC gene polymorphism affects the susceptibility to WarfarinPMID:17048007 PMID:17496169
PROCincreases response to substanceEXP 6480464CTDPROC protein results in increased susceptibility to WarfarinPMID:17496169
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