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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737250
Species: Mus musculus
RGD Object: Gene
Symbol: Itpr2
Name: inositol 1,4,5-triphosphate receptor 2
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Itpr2decreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of ITPR2 mRNAPMID:29095437
Itpr2increases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of ITPR2 mRNAPMID:34091186
Itpr2multiple interactionsEXP 6480464CTDantimony trichloride promotes the reaction [Arsenic Trioxide results in increased expression of ITPR2 mRNA]; Arsenic Trioxide promotes the reaction [antimony trichloride results in increased expression of ITPR2 mRNA]; Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of ITPR2 mRNA]PMID:29095437 PMID:34091186
Itpr2increases expressionISOITPR2 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of ITPR2 proteinPMID:30093655
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