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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735355
Species: Homo sapiens
RGD Object: Gene
Symbol: GABRB2
Name: gamma-aminobutyric acid type A receptor subunit beta2
Acc ID: CHEBI:8206
Term: picrotoxinin
Definition: A picrotoxane sesquiterpenoid that is 3a,4,5,6,7,7a-hexahydro-1H-indene-3,7-dicarboxylic acid which is substituted at positions 3a, 6, and 7a by methyl, isopropenyl, and hydroxy groups, respectively; in which the double bond at position 2-3 has been epoxidised; and in which the carboxy groups at positions 3 and 7 have undergone gamma-lactone formation by O-alkylation to positions 4 and 5, respectively. A component of picrotoxin.
Chemical ID: MESH:C022961
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GABRB2multiple interactionsEXP 6480464CTDpicrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]PMID:29038840
GABRB2increases response to substanceISOGabrb2 (Rattus norvegicus)6480464CTDGABRB2 protein results in increased susceptibility to picrotoxininPMID:29038840
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